View source for Arginase

<StructureSection load='1hqg' size='400' side='right' caption='Structure of rat arginase containing Mn+2 (purple) complex with ornithine (cyan) and urea (yellow) (PDB code [[1hqg]]).' scene='59/593950/Cv/1'>

== Function ==

'''Arginase''' (Arg) catalyzes the conversion of arginine to ornithine and urea.  Arg is the final enzyme in the urea cycle.  Arg requires 2 manganese ions for functioning.<ref>PMID:18360740</ref>

== Disease ==

Arg deficiency is an inherited disorder causing the accumulation of toxic urea in the blood.

== Structural highlights ==

The manganese ions are located at the bottom of a 15A cleft. <scene name='59/593950/Cv/4'>Active site</scene>. The proposed reaction mechanism involves <scene name='59/593950/Cv/5'>H141, D128, E277</scene> in rat.<ref>PMID:11258880</ref>

==3D structures of arginase==
[[Arginase 3D structures]]

</StructureSection>

== References ==
<references/>

[[Category:Topic Page]]