View source for Concanavalin

<StructureSection load='1qdc' size='350' side='right' caption='Concanavalin A complex with trisacchride, Mn+2 (small purple), Cl- (large green) and Ca+2 (small green) ions (large purple) (PDB entry [[1qdc]])' scene='41/415806/Cv/1'>
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== Function ==

'''Concanavalin A''' (ConA) is a carbohydrate-binding protein from jack-bean (''Canavalia ensiformis'').  It binds to certain sugars and to metal.  It is used to characterize glycoproteins on cell surfaces.<ref>PMID:9546043</ref>.   
*'''Concanavalin B''' (ConB) is related to chitinase with 40% sequence identity.<ref>PMID:7490746</ref>.  
*'''Concanavalin BR''' (ConBR) is ConA from Brazilian jack bean.
*'''Concanavalin V''' (ConV) is a D-mannose/D-glucose-binding lectin.

== Relevance ==

ConA has therapeutic effect on liver cancer.

== Structural highlights ==

ConA is the <scene name='41/415806/Cv/2'>homotetramer</scene> with D2 symmetry. ConA contains a <scene name='41/415806/Cv/7'>metal - Mn+2 and Ca+2 - binding site</scene> as well as a <scene name='41/415806/Cv/8'>sugar binding site</scene>.

== 3D Structures of Concanavalin ==
[[Concanavalin 3D structures]]

</StructureSection>

== References ==
<references/>
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