View source for Protein DJ-1

<StructureSection load='6afa' size='340' side='right' caption='Human DJ-1 complex with inhibitor isatin and Cl-1 (green) (PDB code [[6afa]]).' scene='86/864103/Cv/1'>
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== Function ==

'''Protein DJ-1''' or '''DJ-1''' or '''PARK7''' or '''protein/nucleic acid deglycase DJ-1''' or '''protein deglycase DJ-1''' or '''RNA-binding protein regulatory subunit''' is a cancer- and Parkinson Disease-associated protein which protects cells from toxic stresses.  Dj-1 is an antioxidant and functions in transcription modulatory activity<ref>PMID:18711745</ref>.

== Disease ==

The loss of DJ-1 leads to deficits in the detoxification enzyme NADP-quinone oxidoreductase<ref>PMID:17015834</ref>. Mutations in DJ-1 caused early onset of Parkinson disease<ref>PMID:20304780</ref>.

== Structural highlights ==

The 3D structure of DJ-1 complex with the inhibitor isatin shows the covalent bond formed between isatin and DJ-1 <scene name='86/864103/Cv/4'>conserved residue C106</scene> as well as the <scene name='86/864103/Cv/5'>numerous H-bonding interactions</scene> between the inhibitor and the protein<ref>PMID:30063823</ref>. <scene name='86/864103/Cv/6'>Whole binding site</scene>. Water molecules are shown as red spheres.
== 3D structures of protein DJ-1 ==
[[Protein DJ-1 3D structures]]

</StructureSection>
== References ==
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