View source for Retinoblastoma-binding protein

<StructureSection load='' size='350' side='right' scene='48/485630/Cv/1' caption='Human retinoblastoma-binding protein 7 (green) complex with histone H4 helix (magenta) and As ion (purple) [[3cfs]]'>
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== Function ==
'''Retinoblastoma-binding protein''' (RBBP) or '''histone-binding protein''' are nuclear proteins implicated in the regulation of transcription and differentiation by the retinoblastoma tumor suppressor protein<ref>PMID:9697699</ref>.<br />
*  '''RBBP1''' regulates transcriptional activity<ref>PMID:8414517</ref>.<br />
*  '''RBBP2''' demethylates histone H3 at lysine 4.<br />
*  '''RBBP2 homolog''' see KDM5B in [[Lysine-specific histone demethylase]].<br />
*  '''RBBP5''' is involved in methylation and dimethylation of histone H3<ref>PMID:31544921</ref>.<br />
*  '''RBBP6''' promotes p53 degradation<ref>PMID:21676486</ref>.<br />
*  '''RBBP7''' is a WD-repeat protein that interacts with histone deacetylases<ref>PMID:12376095</ref>.<br />
*  '''RBBP9''' blocks the binding of retinoblastoma protein to one of its signaling partners<ref>PMID:21933118</ref>.<br />.  

== Structural highlights ==
<scene name='48/485630/Cv/6'>RBBP7 interacts with histone H4 in a pocket between its N-terminal α helix</scene> and its negatively charged <scene name='48/485630/Cv/7'>PP loop which contains 2 consecutive Pro residues</scene><ref>PMID:18571423</ref>.<br />.  
==3D structures of retinoblastoma-binding protein==
[[Retinoblastoma-binding protein 3D structures]]

</StructureSection>

== References ==
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