View source for Serpin

<StructureSection load='2xn6' size='350' side='right' caption='Structure of cleaved human serpin A7.  Residues 32-380 (cyan), residues 381-415 (salmon) complex with thyroxine-fluoresein, ethylene glycol and Ca+2 ion (green) (PDB entry [[2xn6]])' scene='51/517379/Cv/1'>
== Function ==
'''Serpin or serine protease inhibitor''' (Ser) are protease inhibitors.<br />
* Ser C1 is [[Antithrombin]].<br />
* Ser A5 is protein C inhibitor.<br />
* Ser A6 is [[Corticosteroid-binding globulin]]. <br />
* Ser A8 is angiotensinogen. <br />
* Ser A7 is a thyroxine-binding globulin.<br />
* Ser B1 is leukocyte elastase inhibitor<ref>PMID:26701651</ref>.<br />
* Ser B3 is squamos cell carcinoma antigen 1<ref>PMID:20527027</ref>. <br />
* Ser B5 is Maspin<ref>PMID:11309327</ref>.<br />
* Ser crmA is cysteine and serine proteinase inhibitor<ref>PMID:9065443</ref>.<br />
* Ser I1 is neuroserpin. <br />
* Ser A10 is protein Z-related protease inhibitor. <br />
* Ser A1 is [[Alpha-1-antitrypsin]]. <br />
* Ser A3 is α 1-antichymotrypsin.<br />
* Ser E1 is [[Plasminogen activator inhibitor]].  

== Disease ==
Mutation in Ser A7 causes partial thyroxine-binding globulin deficiency<ref>PMID:24356794</ref>.  Ser B3 may contribute to tumor cell resistance to anti-neoplastic drugs<ref>PMID:25332258</ref>.  Ser A3 promotes growth of endometrial cancer cells <ref>PMID:24817931</ref>.

==Structural highlights ==
Ser A7 - a thyrosine-binding globulin - <scene name='51/517379/Cv/3'>binding site contains thyroxin derivative</scene><ref>PMID:21325280</ref>. Water molecules are shown as red spheres. 

==3D structures of serpin==
[[Serpin 3D structures]]

</StructureSection>

== References ==
<references/> 
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