View source for Sodium/glucose cotransporter

<StructureSection load='8hez' size='340' side='right' caption='Human glycosylated SGLT2 (cyan) complex with PDZK1-interacting protein (green), drug dapagliflozin and Na+ ion (PDB code [[8hez]])' scene='10/1042600/Cv/1'>
== Function ==

'''Sodium/glucose cotransporter''' (SGLT) is responsible for glucose absorption across membranes.  SGLT1 and SGLT2 which are expressed in different tissues, have similar active sites but differ in their non-active site structures.  '''SGLT1''' is responsible of glucose absorption in the small intestine and '''SGLT2''' in kidney<ref>PMID:26125647</ref>.

== Disease ==

Mutations in SGLT1 cause malabsorption of glucose and galactose<ref>PMID:31081587</ref>.

== Relevance ==

SGLT2 inhibitors aid in hypertension, acute cardiac failure, bradycardia, acute pulmonary oedema, asthma, bronchitis and COPD<ref>PMID:36819350</ref>.

== Structural highlights ==

The drug Dapagliflozin contains a <scene name='10/1042600/Cv/5'>glucose moiety which stacks against residue Y290</scene> of SGLT2. The <scene name='10/1042600/Cv/6'>glucose moiety forms multiple H-bonds</scene> to SGLT2<ref>PMID:38057552</ref>. Water molecule is shown as red sphere.

See also:
*[[Canagliflozin]]
*[[Dapagliflozin]]
*[[Empagliflozin]]
==3D structures of sodium/glucose cotransporter==

[[Sodium/glucose cotransporter 3D structures]]

</StructureSection>
== References ==
<references/>

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