View source for Stathmin

<StructureSection load='3ryf' size='340' side='right' caption='Rat stathmin SLD domain (magenta) complex with tubulin α chain (grey, pink), tubulin β chain (green, yellow), GTP, sulfate and Mg+2 ions  (PDB code [[3ryf]])' scene=''>
== Function ==
'''Stathmin-4''' (STM-4) or '''stathmin-like protein B3''' regulates microtubules dynamics.  Microtubules undergo continuous assembly and disassembly in the cell’s cytoskeleton.  STM-4 binds to tubulin and prevents the latter from polymerization thus preventing microtubule assembly.  Phosphorylation of STM-4 weakens the binding of STM-4 to tubulin enabling the microtubule assembly needed for the formation of mitotic spindle.  Thus, STM-4 is an oncoprotein.  STM-4 contains an SLD (Stathmin-Like Domain) domain of 149 residues which binds the tubulin dimer<ref>PMID:15216892</ref>.

== Disease ==
Decreased levels of STM-4 are found in brains of adults with Down syndrome and Alzheimer disease<ref>PMID:11771751</ref>.

== 3D Structures of stathmin-4 ==
[[Stathmin-4 3D structures]]

</StructureSection>

== References ==
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