CD8: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
No edit summary
Michal Harel (talk | contribs)
32,820 edits
No edit summary
 
(7 intermediate revisions by 2 users not shown)
Line 1: Line 1:
<StructureSection load='3b9k' size='450' side='right' caption='Structure of CD8α (magenta) and CD8β (green) complex with antibody heavy chain (cyan) and light chain (salmon) (PDB entry [[3b9k]])' scene='55/551462/Cv/1'>
<StructureSection load='3b9k' size='350' side='right' caption='Structure of CD8α (magenta) and CD8β (green) complex with antibody heavy chain (cyan) and light chain (salmon) (PDB entry [[3b9k]])' scene='55/551462/Cv/1'>
 
 
== Function ==
    
    
'''CD8''' (or '''Cluster of Differentiation 8''') is a T-cell co-receptor.  CD8 binds to class I MHC protein.  CD8 exists as 2 isoforms: α and β.  CD8 forms a dimer of CD8α and CD8β.  The extracellular domain of CD8 has immunoglobulin variable-like conformation.  This domain of CD8α interacts with α3 domain of class I MHC enhancing the binding of the T-cell receptor and the target cell.
'''CD8''' (or '''Cluster of Differentiation 8''') is a T-cell co-receptor.  CD8 binds to class I MHC protein.  CD8 exists as 2 isoforms: α and β.  CD8 forms a dimer of CD8α and CD8β.  The extracellular domain of CD8 has immunoglobulin variable-like conformation.  This domain of CD8α interacts with α3 domain of class I MHC enhancing the binding of the T-cell receptor and the target cell.<ref>PMID:9916707</ref>
*<scene name='55/551462/Cv/2'>CD8α, CD8β and antibody</scene> ([[3b9k]]).<ref>PMID:18929574</ref>
*<scene name='55/551462/Cv/2'>CD8α, CD8β and antibody</scene> ([[3b9k]]).<ref>PMID:18929574</ref>
</StructureSection>


== 3D Structures of CD8 ==
== 3D Structures of CD8 ==
[[CD8 3D structures]]


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
</StructureSection>
{{#tree:id=OrganizedByTopic|openlevels=0|
 
*CD8
 
**[[1cd8]] – hCD8  extracellular domain – human <BR />
 
*CD8α
 
**[[2hp4]] - hCD8  extracellular domain (mutant) <BR />
**[[1akj]] - hCD8  extracellular domain + class I MHC + β-2-microglobulin + HIV reverse transcriptase peptide <BR />
**[[3qzw]] - hCD8  extracellular domain + class I MHC + β-2-microglobulin + NEF peptide <BR />
**[[1bqh]] - mCD8  extracellular domain + class I MHC + β-2-microglobulin + VSV8 peptide - mouse<BR />
**[[3dmm]] - mCD8  extracellular domain + class I MHC + β-2-microglobulin + peptide <BR />
**[[1nez]] - mCD8  extracellular domain + class I MHC + β-2-microglobulin <BR />
**[[1q69]] - hCD8  residues 209-227 + Lck peptide - NMR<BR />
**[[2arj]] - rCD8  extracellular domain + antibody - rat <BR />
**[[2q3a]] – CD8  extracellular domain – rhesus monkey <BR />
 
*CD8α and CD8β


**[[2atp]] - mCD8 + CD8α CD8β linker<BR />
**[[3b9k]] - mCD8 + antibody <BR />
}}
== References ==
== References ==
<references/>
<references/>
[[Category: Topic Page]]
[[Category: Topic Page]]

Latest revision as of 09:03, 1 May 2019

Structure of CD8α (magenta) and CD8β (green) complex with antibody heavy chain (cyan) and light chain (salmon) (PDB entry 3b9k)

Drag the structure with the mouse to rotate

References

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

Retrieved from "https://proteopedia.org/index.php?title=CD8&oldid=3036149"