Matriptase: Difference between revisions

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== Structural highlights ==
== Structural highlights ==
ST14 active site has the conformation of a typical serine protease like trypsin or chymotrypsin with the <scene name='59/595760/Cv/5'>Ser-His-Asp catalytic triad</scene> and <scene name='59/595760/Cv/6'>Gly-Ser oxyanion hole</scene>.  The <scene name='59/595760/Cv/7'>inhibitor benzamidine blocks the catalytic triad</scene><ref>PMID:11696548</ref>. Water molecules shown as red spheres.
ST14 active site has the conformation of a typical serine protease like trypsin or chymotrypsin with the <scene name='59/595760/Cv/5'>Ser-His-Asp catalytic triad</scene> and <scene name='59/595760/Cv/6'>Gly-Ser oxyanion hole</scene>.  The <scene name='59/595760/Cv/7'>inhibitor benzamidine blocks the catalytic triad</scene><ref>PMID:11696548</ref>. Water molecules shown as red spheres.
</StructureSection>


== 3D Structures of matriptase ==
== 3D Structures of matriptase ==
[[Matriptase 3D structures]]


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
</StructureSection>
{{#tree:id=OrganizedByTopic|openlevels=0|
 
*'''matriptase'''
 
**[[4is5]] – hST14 catalytic domain - human<br />
 
*Matriptase complex with small molecule inhibitor
 
**[[1eax]] – hST14 catalytic domain + benzamidine <br />
**[[3p8g]] – hST14 residues 182-422 (mutant) + benzamidine <br />
**[[2gv6]] – hST14 catalytic domain + benzamidine derivative<br />
**[[4o97]], [[4o9v]] – hST14 catalytic domain + benzamidine derivative + tetrapeptide<br />
**[[3ncl]] – hST14 catalytic domain (mutant) + benzamidine derivative<br />
**[[2gv7]], [[4jz1]], [[4jzi]], [[4jyt]] – hST14 catalytic domain + inhibitor<br />
 
*Matriptase complex with polypeptide inhibitor
 
**[[1eaw]] – hST14 catalytic domain + BPTI<br />
**[[3bn9]] – hST14 catalytic domain + antibody<br />
**[[3nps]], [[3so3]] – hST14 catalytic domain (mutant) + antibody<br />
**[[3p8f]] – hST14 residues 182-422 (mutant) + trypsin inhibitor peptide <br />
**[[4isl]], [[4isn]], [[4iso]] – hST14 catalytic domain (mutant) + Kunitz-type protease inhibitor <br />
}}


== References ==
== References ==
Retrieved from "https://proteopedia.org/Matriptase"