DNA Repair: Difference between revisions

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The discussion on this page is targeted at genetics students, so familiarity with [[DNA]] structure, [[DNA Replication]] and [[Basics of Protein Structure]] is assumed.

'''DNA ~~Repair~~''' is necessary to maintain genome fidelity. Errors in DNA can arise from many different sources. Errors introduced in the replication process are the simplest source. This leads to non-Watson-Crick base pairs and local distortions in the helix. Bases can also be damaged by oxidizing agents, alkylating agents or UV light. This page will discuss different strategies for repairing these types of DNA damage. Click the green links to see depictions that match the words.

'''DNA repair''' is necessary to maintain genome fidelity. Errors in DNA can arise from many different sources. Errors introduced in the replication process are the simplest source. This leads to non-Watson-Crick base pairs and local distortions in the helix. Bases can also be damaged by oxidizing agents, alkylating agents or UV light. This page will discuss different strategies for repairing these types of DNA damage. Click the green links to see depictions that match the words.

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=== Monomer Structure ===

<scene name='92/925552/5_monomers/4'>RecA</scene> is one of the many proteins that is involved in recombination cross-over events and during recombination repair in response to single strand DNA breaks. RecA is a rather small monomer protein that can multiplex with itself up to thousands of RecA proteins to associate with ssDNA. The structure of RecA was determined through x-ray crystallography and each monomer contains very distinct structural components. These <scene name='92/925552/Reca_domains/4'>components</scene> are a largely helical 30-residue N-terminal region, a 240-residue α/ß ATPase core, and a 64-residue C-terminal

<scene name='92/925552/5_monomers/4'>RecA</scene> is one of the many proteins that is involved in recombination cross-over events and during recombination repair in response to single strand DNA breaks. RecA ([[Recombinase A]]) is a rather small monomer protein that can multiplex with itself up to thousands of RecA proteins to associate with ssDNA. The structure of RecA was determined through x-ray crystallography and each monomer contains very distinct structural components. These <scene name='92/925552/Reca_domains/4'>components</scene> are a largely helical 30-residue N-terminal region, a 240-residue α/ß ATPase core, and a 64-residue C-terminal

globular domain.

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Glycosylase is an enzyme. Its main function is in Base Excision Repair(BER). Base Excision Repair is a DNA repair mechanism that fixes the most common type of DNA damage. BER corrects DNA damage that occurs from oxidation and methylation. BER removes and repairs damaged bases usually these are single-stranded DNA breaks. It also corrects DNA damage that results from small leisures that do not disrupt the double helix<ref>PMID:25252105</ref>.

Glycosylase is an enzyme. Its main function is in Base Excision Repair(BER). Base Excision Repair is a DNA repair mechanism that fixes the most common type of DNA damage. BER corrects DNA damage that occurs from oxidation and methylation. BER removes and repairs damaged bases usually these are single-stranded DNA breaks. It also corrects DNA damage that results from small leisures that do not disrupt the double helix<ref>PMID:25252105</ref>. See also [[DNA glycosylase]].

=== Function ===

DNA Repair: Difference between revisions

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@@ Line 1: / Line 1: @@
 The discussion on this page is targeted at genetics students, so familiarity with [[DNA]] structure, [[DNA Replication]] and [[Basics of Protein Structure]] is assumed.
-'''DNA Repair''' is necessary to maintain genome fidelity. Errors in DNA can arise from many different sources.  Errors introduced in the replication process are the simplest source.  This leads to non-Watson-Crick base pairs and local distortions in the helix.  Bases can also be damaged by oxidizing agents, alkylating agents or UV light.  This page will discuss different strategies for repairing these types of DNA damage. Click the green links to see depictions that match the words.
+'''DNA repair''' is necessary to maintain genome fidelity. Errors in DNA can arise from many different sources.  Errors introduced in the replication process are the simplest source.  This leads to non-Watson-Crick base pairs and local distortions in the helix.  Bases can also be damaged by oxidizing agents, alkylating agents or UV light.  This page will discuss different strategies for repairing these types of DNA damage. Click the green links to see depictions that match the words.
 <StructureSection load='2aor' size='350' side='right' scene='' caption='MutH complex with DNA, AMP derivative and Ca+2 ion (PDB id [[2aor]])'>
@@ Line 51: / Line 51: @@
 === Monomer Structure ===
-<scene name='92/925552/5_monomers/4'>RecA</scene> is one of the many proteins that is involved in recombination cross-over events and during recombination repair in response to single strand DNA breaks. RecA is a rather small monomer protein that can multiplex with itself up to thousands of RecA proteins to associate with ssDNA. The structure of RecA was determined through x-ray crystallography and each monomer contains very distinct structural components. These <scene name='92/925552/Reca_domains/4'>components</scene> are a largely helical 30-residue N-terminal region, a 240-residue α/ß ATPase core, and a 64-residue C-terminal
+<scene name='92/925552/5_monomers/4'>RecA</scene> is one of the many proteins that is involved in recombination cross-over events and during recombination repair in response to single strand DNA breaks. RecA ([[Recombinase A]]) is a rather small monomer protein that can multiplex with itself up to thousands of RecA proteins to associate with ssDNA. The structure of RecA was determined through x-ray crystallography and each monomer contains very distinct structural components. These <scene name='92/925552/Reca_domains/4'>components</scene> are a largely helical 30-residue N-terminal region, a 240-residue α/ß ATPase core, and a 64-residue C-terminal
 globular domain.
@@ Line 85: / Line 85: @@
-Glycosylase is an enzyme. Its main function is in Base Excision Repair(BER). Base Excision Repair is a DNA repair mechanism that fixes the most common type of DNA damage. BER corrects DNA damage that occurs from oxidation and methylation. BER removes and repairs damaged bases usually these are single-stranded DNA breaks. It also corrects DNA damage that results from small leisures that do not disrupt the double helix<ref>PMID:25252105</ref>.
+Glycosylase is an enzyme. Its main function is in Base Excision Repair(BER). Base Excision Repair is a DNA repair mechanism that fixes the most common type of DNA damage. BER corrects DNA damage that occurs from oxidation and methylation. BER removes and repairs damaged bases usually these are single-stranded DNA breaks. It also corrects DNA damage that results from small leisures that do not disrupt the double helix<ref>PMID:25252105</ref>. See also [[DNA glycosylase]].
 === Function ===