1ujy: Difference between revisions

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[[Image:1ujy.gif|left|200px]]


{{Structure
==Solution structure of SH3 domain in Rac/Cdc42 guanine nucleotide exchange factor(GEF) 6==
|PDB= 1ujy |SIZE=350|CAPTION= <scene name='initialview01'>1ujy</scene>
<StructureSection load='1ujy' size='340' side='right'caption='[[1ujy]]' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND=  
<table><tr><td colspan='2'>[[1ujy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UJY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UJY FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
|GENE= KAZUSA ha01154 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ujy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ujy OCA], [https://pdbe.org/1ujy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ujy RCSB], [https://www.ebi.ac.uk/pdbsum/1ujy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ujy ProSAT], [https://www.topsan.org/Proteins/RSGI/1ujy TOPSAN]</span></td></tr>
}}
</table>
== Disease ==
[https://www.uniprot.org/uniprot/ARHG6_HUMAN ARHG6_HUMAN] Defects in ARHGEF6 are the cause of mental retardation X-linked type 46 (MRX46) [MIM:[https://omim.org/entry/300436 300436]. Mental retardation is a mental disorder characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non-syndromic mental retardation patients do not manifest other clinical signs.<ref>PMID:11017088</ref>
== Function ==
[https://www.uniprot.org/uniprot/ARHG6_HUMAN ARHG6_HUMAN] Acts as a RAC1 guanine nucleotide exchange factor (GEF).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uj/1ujy_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ujy ConSurf].
<div style="clear:both"></div>


'''Solution structure of SH3 domain in Rac/Cdc42 guanine nucleotide exchange factor(GEF) 6'''
==See Also==
 
*[[Rho guanine nucleotide exchange factor 3D structures|Rho guanine nucleotide exchange factor 3D structures]]
 
== References ==
==Disease==
<references/>
Known diseases associated with this structure: Mental retardation, X-linked nonspecific, type 46 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=300267 300267]]
__TOC__
 
</StructureSection>
==About this Structure==
1UJY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UJY OCA].
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Aoki, M.]]
[[Category: Aoki M]]
[[Category: He, F.]]
[[Category: He F]]
[[Category: Hirota, H.]]
[[Category: Hirota H]]
[[Category: Inoue, M.]]
[[Category: Inoue M]]
[[Category: Kigawa, T.]]
[[Category: Kigawa T]]
[[Category: Kikuno, R.]]
[[Category: Kikuno R]]
[[Category: Kobayashi, N.]]
[[Category: Kobayashi N]]
[[Category: Koshiba, S.]]
[[Category: Koshiba S]]
[[Category: Matsuda, T.]]
[[Category: Matsuda T]]
[[Category: Matsuo, Y.]]
[[Category: Matsuo Y]]
[[Category: Muto, Y.]]
[[Category: Muto Y]]
[[Category: Nagase, T.]]
[[Category: Nagase T]]
[[Category: Nagayama, M.]]
[[Category: Nagayama M]]
[[Category: Ohara, O.]]
[[Category: Ohara O]]
[[Category: Osanai, T.]]
[[Category: Osanai T]]
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
[[Category: Seki E]]
[[Category: Seki, E.]]
[[Category: Shirouzu M]]
[[Category: Shirouzu, M.]]
[[Category: Tanaka A]]
[[Category: Tanaka, A.]]
[[Category: Terada T]]
[[Category: Terada, T.]]
[[Category: Uda H]]
[[Category: Uda, H.]]
[[Category: Yabuki T]]
[[Category: Yabuki, T.]]
[[Category: Yokoyama S]]
[[Category: Yokoyama, S.]]
[[Category: Yoshida M]]
[[Category: Yoshida, M.]]
[[Category: gef 6]]
[[Category: nmr]]
[[Category: riken structural genomics/proteomics initiative]]
[[Category: rsgi]]
[[Category: sh3 domain]]
[[Category: structural genomic]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:32:59 2008''
Retrieved from "https://proteopedia.org/1ujy"