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[[Image:1ml5.png|left|200px]]


{{STRUCTURE_1ml5|  PDB=1ml5  |  SCENE=  }}
==Structure of the E. coli ribosomal termination complex with release factor 2==
 
<SX load='1ml5' size='340' side='right' viewer='molstar' caption='[[1ml5]], [[Resolution|resolution]] 14.00&Aring;' scene=''>
===Structure of the E. coli ribosomal termination complex with release factor 2===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1ml5]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ML5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ML5 FirstGlance]. <br>
{{ABSTRACT_PUBMED_12511961}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 14&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1MA:6-HYDRO-1-METHYLADENOSINE-5-MONOPHOSPHATE'>1MA</scene>, <scene name='pdbligand=2MG:2N-METHYLGUANOSINE-5-MONOPHOSPHATE'>2MG</scene>, <scene name='pdbligand=5MC:5-METHYLCYTIDINE-5-MONOPHOSPHATE'>5MC</scene>, <scene name='pdbligand=5MU:5-METHYLURIDINE+5-MONOPHOSPHATE'>5MU</scene>, <scene name='pdbligand=7MG:7N-METHYL-8-HYDROGUANOSINE-5-MONOPHOSPHATE'>7MG</scene>, <scene name='pdbligand=H2U:5,6-DIHYDROURIDINE-5-MONOPHOSPHATE'>H2U</scene>, <scene name='pdbligand=M2G:N2-DIMETHYLGUANOSINE-5-MONOPHOSPHATE'>M2G</scene>, <scene name='pdbligand=OMC:O2-METHYLYCYTIDINE-5-MONOPHOSPHATE'>OMC</scene>, <scene name='pdbligand=OMG:O2-METHYLGUANOSINE-5-MONOPHOSPHATE'>OMG</scene>, <scene name='pdbligand=PSU:PSEUDOURIDINE-5-MONOPHOSPHATE'>PSU</scene>, <scene name='pdbligand=YG:WYBUTOSINE'>YG</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ml5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ml5 OCA], [https://pdbe.org/1ml5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ml5 RCSB], [https://www.ebi.ac.uk/pdbsum/1ml5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ml5 ProSAT]</span></td></tr>
[[1ml5]] is a 45 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ML5 OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/RF2_ECOLI RF2_ECOLI] Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.[HAMAP-Rule:MF_00094]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ml/1ml5_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ml5 ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Ribosomal protein L1|Ribosomal protein L1]]
*[[MHC 3D structures|MHC 3D structures]]
*[[Ribosomal protein L11|Ribosomal protein L11]]
*[[MHC I 3D structures|MHC I 3D structures]]
*[[Ribosomal protein L13|Ribosomal protein L13]]
*[[Ribosomal protein THX 3D structures|Ribosomal protein THX 3D structures]]
*[[Ribosomal protein L14|Ribosomal protein L14]]
*[[Transfer RNA (tRNA)|Transfer RNA (tRNA)]]
*[[Ribosomal protein L15|Ribosomal protein L15]]
__TOC__
*[[Ribosomal protein L16|Ribosomal protein L16]]
</SX>
*[[Ribosomal protein L18|Ribosomal protein L18]]
*[[Ribosomal protein L19|Ribosomal protein L19]]
*[[Ribosomal protein L2|Ribosomal protein L2]]
*[[Ribosomal protein L22|Ribosomal protein L22]]
*[[Ribosomal protein L23|Ribosomal protein L23]]
*[[Ribosomal protein L24|Ribosomal protein L24]]
*[[Ribosomal protein L25|Ribosomal protein L25]]
*[[Ribosomal protein L29|Ribosomal protein L29]]
*[[Ribosomal protein L3|Ribosomal protein L3]]
*[[Ribosomal protein L30|Ribosomal protein L30]]
*[[Ribosomal protein L4|Ribosomal protein L4]]
*[[Ribosomal protein L5|Ribosomal protein L5]]
*[[Ribosomal protein L6|Ribosomal protein L6]]
*[[Ribosomal protein S10|Ribosomal protein S10]]
*[[Ribosomal protein S11|Ribosomal protein S11]]
*[[Ribosomal protein S12|Ribosomal protein S12]]
*[[Ribosomal protein S13|Ribosomal protein S13]]
*[[Ribosomal protein S14|Ribosomal protein S14]]
*[[Ribosomal protein S15|Ribosomal protein S15]]
*[[Ribosomal protein S16|Ribosomal protein S16]]
*[[Ribosomal protein S17|Ribosomal protein S17]]
*[[Ribosomal protein S18|Ribosomal protein S18]]
*[[Ribosomal protein S19|Ribosomal protein S19]]
*[[Ribosomal protein S2|Ribosomal protein S2]]
*[[Ribosomal protein S20|Ribosomal protein S20]]
*[[Ribosomal protein S3|Ribosomal protein S3]]
*[[Ribosomal protein S4|Ribosomal protein S4]]
*[[Ribosomal protein S5|Ribosomal protein S5]]
*[[Ribosomal protein S6|Ribosomal protein S6]]
*[[Ribosomal protein S7|Ribosomal protein S7]]
*[[Ribosomal protein S8|Ribosomal protein S8]]
*[[Ribosomal protein S9|Ribosomal protein S9]]
*[[Ribosomal protein THX|Ribosomal protein THX]]
 
==Reference==
<ref group="xtra">PMID:012511961</ref><references group="xtra"/>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Ehrenberg, M.]]
[[Category: Large Structures]]
[[Category: Heel, M van.]]
[[Category: Ehrenberg M]]
[[Category: Klaholz, B P.]]
[[Category: Klaholz BP]]
[[Category: Myasnikov, A G.]]
[[Category: Myasnikov AG]]
[[Category: Orlova, E V.]]
[[Category: Orlova EV]]
[[Category: Pape, T.]]
[[Category: Pape T]]
[[Category: Vestergaard, B.]]
[[Category: Vestergaard B]]
[[Category: Zavialov, A V.]]
[[Category: Zavialov AV]]
[[Category: Angular reconstitution]]
[[Category: Van Heel M]]
[[Category: Cryo-eletron microscopy]]
[[Category: E. coli]]
[[Category: Release factor]]
[[Category: Ribosome]]
[[Category: Termination of protein synthesis]]

Latest revision as of 07:45, 14 February 2024

Structure of the E. coli ribosomal termination complex with release factor 2

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