3ham: Difference between revisions

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[[Image:3ham.png|left|200px]]


<!--
==Structure of the gentamicin-APH(2")-IIa complex==
The line below this paragraph, containing "STRUCTURE_3ham", creates the "Structure Box" on the page.
<StructureSection load='3ham' size='340' side='right'caption='[[3ham]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3ham]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Enterococcus_faecium Enterococcus faecium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HAM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HAM FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=LLL:(2R,3R,4R,5R)-2-((1S,2S,3R,4S,6R)-4,6-DIAMINO-3-((2R,3R,6S)-3-AMINO-6-(AMINOMETHYL)-TETRAHYDRO-2H-PYRAN-2-YLOXY)-2-HYDROXYCYCLOHEXYLOXY)-5-METHYL-4-(METHYLAMINO)-TETRAHYDRO-2H-PYRAN-3,5-DIOL'>LLL</scene></td></tr>
{{STRUCTURE_3ham| PDB=3ham |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ham FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ham OCA], [https://pdbe.org/3ham PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ham RCSB], [https://www.ebi.ac.uk/pdbsum/3ham PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ham ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q9EVD7_ENTFC Q9EVD7_ENTFC]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ha/3ham_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ham ConSurf].
<div style="clear:both"></div>


===Structure of the gentamicin-APH(2")-IIa complex===
==See Also==
 
*[[Phosphotransferase|Phosphotransferase]]
 
*[[Phosphotransferase 3D structures|Phosphotransferase 3D structures]]
<!--
__TOC__
The line below this paragraph, {{ABSTRACT_PUBMED_19429619}}, adds the Publication Abstract to the page
</StructureSection>
(as it appears on PubMed at http://www.pubmed.gov), where 19429619 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_19429619}}
 
==About this Structure==
[[3ham]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterococcus_faecium Enterococcus faecium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HAM OCA].
 
==Reference==
<ref group="xtra">PMID:019429619</ref><references group="xtra"/>
[[Category: Enterococcus faecium]]
[[Category: Enterococcus faecium]]
[[Category: Baker, E N.]]
[[Category: Large Structures]]
[[Category: Smith, C A.]]
[[Category: Baker EN]]
[[Category: Vakulenko, S B.]]
[[Category: Smith CA]]
[[Category: Young, P G.]]
[[Category: Vakulenko SB]]
[[Category: Aminoglycoside]]
[[Category: Young PG]]
[[Category: Antibiotic resistance]]
[[Category: Gentamicin]]
[[Category: Transferase]]

Latest revision as of 09:58, 21 February 2024

Structure of the gentamicin-APH(2")-IIa complex

3ham, resolution 2.50Å

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