8qmo: Difference between revisions
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==Cryo-EM structure of the benzo[a]pyrene-bound Hsp90-XAP2-AHR complex== | |||
<StructureSection load='8qmo' size='340' side='right'caption='[[8qmo]], [[Resolution|resolution]] 2.76Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8qmo]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8QMO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8QMO FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.76Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MOO:MOLYBDATE+ION'>MOO</scene>, <scene name='pdbligand=W62:benzo[a]pyrene'>W62</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8qmo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8qmo OCA], [https://pdbe.org/8qmo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8qmo RCSB], [https://www.ebi.ac.uk/pdbsum/8qmo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8qmo ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/HS90B_HUMAN HS90B_HUMAN] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:16478993</ref> <ref>PMID:19696785</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Ancelin A]] | |||
[[Category: Bourguet W]] | |||
[[Category: Carivenc C]] | |||
[[Category: Grandvuillemin L]] | |||
[[Category: Gruszczyk J]] | |||
[[Category: Hesketh EL]] | |||
[[Category: Kwong HS]] | |||
[[Category: Lai-Kee-Him J]] | |||
[[Category: Lancey C]] | |||
[[Category: Ragan TJ]] | |||
[[Category: Sirounian S]] | |||
Latest revision as of 13:12, 1 March 2024
Cryo-EM structure of the benzo[a]pyrene-bound Hsp90-XAP2-AHR complex
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