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==Crystal Structure of Steptococcus pneumoniae Undecaprenyl pyrophosphate Synthase (UPPS)==
==Crystal Structure of Steptococcus pneumoniae Undecaprenyl pyrophosphate Synthase (UPPS)==
<StructureSection load='5kh2' size='340' side='right' caption='[[5kh2]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='5kh2' size='340' side='right'caption='[[5kh2]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5kh2]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KH2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5KH2 FirstGlance]. <br>
<table><tr><td colspan='2'>[[5kh2]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae_TIGR4 Streptococcus pneumoniae TIGR4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KH2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5KH2 FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5kh4|5kh4]], [[5kh5|5kh5]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5kh2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kh2 OCA], [http://pdbe.org/5kh2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5kh2 RCSB], [http://www.ebi.ac.uk/pdbsum/5kh2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5kh2 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5kh2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kh2 OCA], [https://pdbe.org/5kh2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5kh2 RCSB], [https://www.ebi.ac.uk/pdbsum/5kh2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5kh2 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/ISPT_STRPN ISPT_STRPN]] Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
[https://www.uniprot.org/uniprot/ISPT_STRPN ISPT_STRPN] Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Undecaprenyl pyrophosphate synthase (UppS) is an essential enzyme in bacterial cell wall synthesis. Here we report the discovery of Staphylococcus aureus UppS inhibitors from an Encoded Library Technology screen and demonstrate binding to the hydrophobic substrate site through cocrystallography studies. The use of bacterial strains with regulated uppS expression and inhibitor resistant mutant studies confirmed that the whole cell activity was the result of UppS inhibition, validating UppS as a druggable antibacterial target.


Discovery and Characterization of a Class of Pyrazole Inhibitors of Bacterial Undecaprenyl Pyrophosphate Synthase.,Concha N, Huang J, Bai X, Benowitz A, Brady P, Grady LC, Kryn LH, Holmes D, Ingraham K, Jin Q, Pothier Kaushansky L, McCloskey L, Messer JA, O'Keefe H, Patel A, Satz AL, Sinnamon RH, Schneck J, Skinner SR, Summerfield J, Taylor A, Taylor JD, Evindar G, Stavenger RA J Med Chem. 2016 Jul 20. PMID:27379833<ref>PMID:27379833</ref>
==See Also==
 
*[[Undecaprenyl pyrophosphate synthase|Undecaprenyl pyrophosphate synthase]]
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 5kh2" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Concha, N O]]
[[Category: Large Structures]]
[[Category: Bacterial]]
[[Category: Streptococcus pneumoniae TIGR4]]
[[Category: Native]]
[[Category: Concha NO]]
[[Category: Transferase]]
[[Category: Undecaprenyl s. pneumoniae]]
[[Category: Upp]]

Latest revision as of 12:40, 6 March 2024

Crystal Structure of Steptococcus pneumoniae Undecaprenyl pyrophosphate Synthase (UPPS)

5kh2, resolution 2.30Å

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