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==Crystal structure of Yersinia pestis GlmU in comlex with alpha-D-glucosamine 1-phosphate (GP1)==
 
<StructureSection load='4fce' size='340' side='right' caption='[[4fce]], [[Resolution|resolution]] 1.96&Aring;' scene=''>
==Crystal structure of Yersinia pestis GlmU in complex with alpha-D-glucosamine 1-phosphate (GP1)==
<StructureSection load='4fce' size='340' side='right'caption='[[4fce]], [[Resolution|resolution]] 1.96&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4fce]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Yersinia_pestis_co92 Yersinia pestis co92]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FCE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FCE FirstGlance]. <br>
<table><tr><td colspan='2'>[[4fce]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Yersinia_pestis_CO92 Yersinia pestis CO92]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FCE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FCE FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GP1:GLUCOSAMINE+1-PHOSPHATE'>GP1</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.955&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3fww|3fww]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GP1:GLUCOSAMINE+1-PHOSPHATE'>GP1</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">glmU, YPTB3965 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=214092 Yersinia pestis CO92])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fce FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fce OCA], [https://pdbe.org/4fce PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fce RCSB], [https://www.ebi.ac.uk/pdbsum/4fce PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fce ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fce FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fce OCA], [http://pdbe.org/4fce PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4fce RCSB], [http://www.ebi.ac.uk/pdbsum/4fce PDBsum]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/GLMU_YERPS GLMU_YERPS]] Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity).  
[https://www.uniprot.org/uniprot/GLMU_YERPE GLMU_YERPE] Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.[HAMAP-Rule:MF_01631]
 
==See Also==
*[[N-acetylglucosamine-1-phosphate uridyltransferase|N-acetylglucosamine-1-phosphate uridyltransferase]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Yersinia pestis co92]]
[[Category: Large Structures]]
[[Category: Anderson, W F]]
[[Category: Yersinia pestis CO92]]
[[Category: Structural genomic]]
[[Category: Anderson WF]]
[[Category: Gu, M]]
[[Category: Gu M]]
[[Category: Joachimiak, A]]
[[Category: Joachimiak A]]
[[Category: Kuhn, M]]
[[Category: Kuhn M]]
[[Category: Nocek, B]]
[[Category: Nocek B]]
[[Category: Alpha-d-glucosamine 1-phosphate]]
[[Category: Glmu]]
[[Category: Glmu. csgid]]
[[Category: Gp1]]
[[Category: National institute of allergy and infectious disease]]
[[Category: Niaid]]
[[Category: Transferase]]

Latest revision as of 15:21, 14 March 2024

Crystal structure of Yersinia pestis GlmU in complex with alpha-D-glucosamine 1-phosphate (GP1)

4fce, resolution 1.96Å

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