2j4l: Difference between revisions

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[[Image:2j4l.jpg|left|200px]]


{{Structure
==Crystal structure of uridylate kinase from Sulfolobus solfataricus in complex with UTP to 2.8 Angstrom resolution==
|PDB= 2j4l |SIZE=350|CAPTION= <scene name='initialview01'>2j4l</scene>, resolution 2.80&Aring;
<StructureSection load='2j4l' size='340' side='right'caption='[[2j4l]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
|SITE= <scene name='pdbsite=AC1:Utp+Binding+Site+For+Chain+L'>AC1</scene>
== Structural highlights ==
|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene> and <scene name='pdbligand=UTP:URIDINE 5'-TRIPHOSPHATE'>UTP</scene>
<table><tr><td colspan='2'>[[2j4l]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharolobus_solfataricus Saccharolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J4L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2J4L FirstGlance]. <br>
|ACTIVITY= [http://en.wikipedia.org/wiki/UMP_kinase UMP kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.22 2.7.4.22]  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
|GENE=  
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=UTP:URIDINE+5-TRIPHOSPHATE'>UTP</scene></td></tr>
}}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2j4l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j4l OCA], [https://pdbe.org/2j4l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2j4l RCSB], [https://www.ebi.ac.uk/pdbsum/2j4l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2j4l ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PYRH_SACS2 PYRH_SACS2] Catalyzes the reversible phosphorylation of UMP to UDP, with ATP as the most efficient phosphate donor. Is also able to phosphorylate dUMP, although much less efficiently.<ref>PMID:17297917</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j4/2j4l_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2j4l ConSurf].
<div style="clear:both"></div>


'''CRYSTAL STRUCTURE OF URIDYLATE KINASE FROM SULFOLOBUS SOLFATARICUS IN COMPLEX WITH UTP TO 2.8 ANGSTROM RESOLUTION'''
==See Also==
 
*[[Uridylate kinase|Uridylate kinase]]
 
== References ==
==About this Structure==
<references/>
2J4L is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J4L OCA].
__TOC__
[[Category: Single protein]]
</StructureSection>
[[Category: Sulfolobus solfataricus]]
[[Category: Large Structures]]
[[Category: UMP kinase]]
[[Category: Saccharolobus solfataricus]]
[[Category: Jensen, K F.]]
[[Category: Jensen KF]]
[[Category: Jensen, K S.]]
[[Category: Jensen KS]]
[[Category: Johansson, E.]]
[[Category: Johansson E]]
[[Category: MG]]
[[Category: UTP]]
[[Category: aspartokinase fold]]
[[Category: nucleoside monophosphate kinase]]
[[Category: pyrimidine nucleotide synthesis]]
[[Category: transferase]]
[[Category: ump kinase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:37:07 2008''

Latest revision as of 06:41, 1 May 2024

Crystal structure of uridylate kinase from Sulfolobus solfataricus in complex with UTP to 2.8 Angstrom resolution

2j4l, resolution 2.80Å

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