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==Structure of the N-terminal domain of the yeast telomerase reverse transcriptase==
==Structure of the N-terminal domain of the yeast telomerase reverse transcriptase==
<StructureSection load='5npt' size='340' side='right' caption='[[5npt]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
<StructureSection load='5npt' size='340' side='right'caption='[[5npt]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5npt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_34438 Atcc 34438]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NPT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NPT FirstGlance]. <br>
<table><tr><td colspan='2'>[[5npt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Ogataea_polymorpha Ogataea polymorpha]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NPT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5NPT FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5npt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5npt OCA], [http://pdbe.org/5npt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5npt RCSB], [http://www.ebi.ac.uk/pdbsum/5npt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5npt ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5npt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5npt OCA], [https://pdbe.org/5npt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5npt RCSB], [https://www.ebi.ac.uk/pdbsum/5npt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5npt ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Function ==
== Publication Abstract from PubMed ==
[https://www.uniprot.org/uniprot/R4IT35_9ASCO R4IT35_9ASCO]
The elongation of single-stranded DNA repeats at the 3'-ends of chromosomes by telomerase is a key process in maintaining genome integrity in eukaryotes. Abnormal activation of telomerase leads to uncontrolled cell division, whereas its down-regulation is attributed to ageing and several pathologies related to early cell death. Telomerase function is based on the dynamic interactions of its catalytic subunit (TERT) with nucleic acids-telomerase RNA, telomeric DNA and the DNA/RNA heteroduplex. Here, we present the crystallographic and NMR structures of the N-terminal (TEN) domain of TERT from the thermotolerant yeast Hansenula polymorpha and demonstrate the structural conservation of the core motif in evolutionarily divergent organisms. We identify the TEN residues that are involved in interactions with the telomerase RNA and in the recognition of the 'fork' at the distal end of the DNA product/RNA template heteroduplex. We propose that the TEN domain assists telomerase biological function and is involved in restricting the size of the heteroduplex during telomere repeat synthesis.


Structure and function of the N-terminal domain of the yeast telomerase reverse transcriptase.,Petrova OA, Mantsyzov AB, Rodina EV, Efimov SV, Hackenberg C, Hakanpaa J, Klochkov VV, Lebedev AA, Chugunova AA, Malyavko AN, Zatsepin TS, Mishin AV, Zvereva MI, Lamzin VS, Dontsova OA, Polshakov VI Nucleic Acids Res. 2017 Dec 23. pii: 4774275. doi: 10.1093/nar/gkx1275. PMID:29294091<ref>PMID:29294091</ref>
==See Also==
 
*[[Telomerase 3D structures|Telomerase 3D structures]]
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 5npt" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Atcc 34438]]
[[Category: Large Structures]]
[[Category: Dontsova, O A]]
[[Category: Ogataea polymorpha]]
[[Category: Hackenberg, C]]
[[Category: Dontsova OA]]
[[Category: Hakanpaa, J]]
[[Category: Hackenberg C]]
[[Category: Lamzin, V S]]
[[Category: Hakanpaa J]]
[[Category: Lebedev, A A]]
[[Category: Lamzin VS]]
[[Category: Petrova, O A]]
[[Category: Lebedev AA]]
[[Category: Rodina, E V]]
[[Category: Petrova OA]]
[[Category: Zvereva, M I]]
[[Category: Rodina EV]]
[[Category: Telomerase]]
[[Category: Zvereva MI]]
[[Category: Transcription]]

Latest revision as of 07:27, 1 May 2024

Structure of the N-terminal domain of the yeast telomerase reverse transcriptase

5npt, resolution 2.40Å

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