4ei4: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4ei4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EI4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EI4 FirstGlance]. <br> | <table><tr><td colspan='2'>[[4ei4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EI4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EI4 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0Q2:(1R,3R)-3-(2-METHYLIMIDAZO[4,5-D]PYRROLO[2,3-B]PYRIDIN-1(8H)-YL)CYCLOHEXANOL'>0Q2</scene>, <scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.22Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0Q2:(1R,3R)-3-(2-METHYLIMIDAZO[4,5-D]PYRROLO[2,3-B]PYRIDIN-1(8H)-YL)CYCLOHEXANOL'>0Q2</scene>, <scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ei4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ei4 OCA], [https://pdbe.org/4ei4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ei4 RCSB], [https://www.ebi.ac.uk/pdbsum/4ei4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ei4 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ei4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ei4 OCA], [https://pdbe.org/4ei4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ei4 RCSB], [https://www.ebi.ac.uk/pdbsum/4ei4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ei4 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/JAK1_HUMAN JAK1_HUMAN] Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor. | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
Latest revision as of 06:56, 27 November 2024
JAK1 kinase (JH1 domain) in complex with compound 20
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