Furin: Difference between revisions

(3 intermediate revisions by 2 users not shown)

Line 7:

== Relevance ==

High furin activity promotes the malignant phenotype of cancer cells in head and neck squamous cell carcinoma, breast cancer and <ref>PMID:28369813</ref>. Furin has a role in atherosclerosis<ref>PMID:28400053</ref>. The new coronavirus SARS-CoV19 genome sequence shows a furin-like cleavage site in the spike protein. This cleavage site has potential implications in the development of antivirals<ref>PMID:32057769</ref>.

High furin activity promotes the malignant phenotype of cancer cells in head and neck squamous cell carcinoma, breast cancer and <ref>PMID:28369813</ref>. Furin has a role in atherosclerosis<ref>PMID:28400053</ref>. The new coronavirus SARS-CoV19 genome sequence shows a furin-like cleavage site in the spike protein. This cleavage site has potential implications in the development of antivirals<ref>PMID:32057769</ref>. See [[SARS-CoV-2 protein S priming by furin]], an animation.

== Structural highlights ==

</StructureSection>

Line 17:

[[5jxg]], [[5jxi]] - hFur - human

[[~~6eqx~~]], [[~~6eqw~~]], [[~~6eqv~~]], [[5jxh]], [[5jxj]], [[6hlb]], [[6hld]], [[6hle]], [[6hza]], [[6hzb]], [[6hzc]], [[6hzd]] - hFur + peptide inhibitor

[[4z2a]] - hFur (mutant)

[[5mim]] - hFur + inhibitor

[[4omc]], [[4omd]], [[4ryd]], [[5jxh]], [[5jxj]], [[6eqv]], [[6eqw]], [[6eqx]], [[6hlb]], [[6hld]], [[6hle]], [[6hza]], [[6hzb]], [[6hzc]], [[6hzd]], [[8b4x]], [[8oyh]] - hFur + peptide inhibitor

[[5mim]], [[6yd2]], [[6yd3]], [[6yd4]], [[6yd7]], [[7lcu]], [[7o1u]], [[7o1w]], [[7o1y]], [[7o20]], [[7o22]], [[7qxy]], [[7qxz]], [[7qy0]], [[7qy2]], [[8b4v]], [[8b4w]] - hFur + inhibitor

[[5jmo]] - hFur + antibody

[[1p8j]] - mFur + peptide inhibitor - mouse

== References ==

[[Category:Topic Page]]

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 7: / Line 7: @@
 == Relevance ==
-High furin activity promotes the malignant phenotype of cancer cells in head and neck squamous cell carcinoma, breast cancer and <ref>PMID:28369813</ref>.  Furin has a role in atherosclerosis<ref>PMID:28400053</ref>.  The new coronavirus SARS-CoV19 genome sequence shows a furin-like cleavage site in the spike protein.  This cleavage site has potential implications in the development of antivirals<ref>PMID:32057769</ref>.
+High furin activity promotes the malignant phenotype of cancer cells in head and neck squamous cell carcinoma, breast cancer and <ref>PMID:28369813</ref>.  Furin has a role in atherosclerosis<ref>PMID:28400053</ref>.  The new coronavirus SARS-CoV19 genome sequence shows a furin-like cleavage site in the spike protein.  This cleavage site has potential implications in the development of antivirals<ref>PMID:32057769</ref>. See [[SARS-CoV-2 protein S priming by furin]], an animation.
-== Structural highlights ==
+<!--== Structural highlights == -->
 </StructureSection>
@@ Line 17: / Line 17: @@
 [[5jxg]], [[5jxi]] - hFur - human<br />
-[[6eqx]], [[6eqw]], [[6eqv]], [[5jxh]], [[5jxj]], [[6hlb]], [[6hld]], [[6hle]], [[6hza]], [[6hzb]], [[6hzc]], [[6hzd]] - hFur + peptide inhibitor<br />
+[[4z2a]] - hFur (mutant)<br />
-[[5mim]] - hFur + inhibitor<br />
+[[4omc]], [[4omd]], [[4ryd]], [[5jxh]], [[5jxj]], [[6eqv]], [[6eqw]], [[6eqx]], [[6hlb]], [[6hld]], [[6hle]], [[6hza]], [[6hzb]], [[6hzc]], [[6hzd]], [[8b4x]], [[8oyh]] - hFur + peptide inhibitor<br />
+[[5mim]], [[6yd2]], [[6yd3]], [[6yd4]], [[6yd7]], [[7lcu]], [[7o1u]], [[7o1w]], [[7o1y]], [[7o20]], [[7o22]], [[7qxy]], [[7qxz]], [[7qy0]], [[7qy2]], [[8b4v]], [[8b4w]] - hFur + inhibitor<br />
+[[5jmo]] - hFur + antibody<br />
 [[1p8j]] - mFur + peptide inhibitor - mouse<br />
 == References ==
 <references/>
 [[Category:Topic Page]]