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==Crystal structure of the C-terminal domain of Ebola virus VP30 (strain Reston-89)==
==Crystal structure of the C-terminal domain of Ebola virus VP30 (strain Reston-89)==
<StructureSection load='3v7o' size='340' side='right' caption='[[3v7o]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
<StructureSection load='3v7o' size='340' side='right'caption='[[3v7o]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3v7o]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Eborr Eborr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V7O OCA]. <br>
<table><tr><td colspan='2'>[[3v7o]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Reston_ebolavirus_-_Reston_(1989) Reston ebolavirus - Reston (1989)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V7O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3V7O FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene><br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">VP30 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=386032 EBORR])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3v7o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v7o OCA], [https://pdbe.org/3v7o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3v7o RCSB], [https://www.ebi.ac.uk/pdbsum/3v7o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3v7o ProSAT]</span></td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3v7o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v7o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3v7o RCSB], [http://www.ebi.ac.uk/pdbsum/3v7o PDBsum]</span></td></tr>
</table>
<table>
== Function ==
[https://www.uniprot.org/uniprot/VP30_EBORR VP30_EBORR] Acts as a transcription anti-termination factor immediately after transcription initiation, but does not affect transcription elongation. This function has been found to be dependent on the formation of an RNA stem-loop at the transcription start site of the first gene. Binds to RNA (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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Structure of the Reston ebolavirus VP30 C-terminal domain.,Clifton MC, Kirchdoerfer RN, Atkins K, Abendroth J, Raymond A, Grice R, Barnes S, Moen S, Lorimer D, Edwards TE, Myler PJ, Saphire EO Acta Crystallogr F Struct Biol Commun. 2014 Apr;70(Pt 4):457-60. doi:, 10.1107/S2053230X14003811. Epub 2014 Mar 25. PMID:24699737<ref>PMID:24699737</ref>
Structure of the Reston ebolavirus VP30 C-terminal domain.,Clifton MC, Kirchdoerfer RN, Atkins K, Abendroth J, Raymond A, Grice R, Barnes S, Moen S, Lorimer D, Edwards TE, Myler PJ, Saphire EO Acta Crystallogr F Struct Biol Commun. 2014 Apr;70(Pt 4):457-60. doi:, 10.1107/S2053230X14003811. Epub 2014 Mar 25. PMID:24699737<ref>PMID:24699737</ref>


From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 3v7o" style="background-color:#fffaf0;"></div>
==See Also==
*[[Nucleoprotein 3D structures|Nucleoprotein 3D structures]]
*[[Transcriptional activator 3D structures|Transcriptional activator 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Eborr]]
[[Category: Large Structures]]
[[Category: Disease, Seattle Structural Genomics Center for Infectious.]]
[[Category: Structural genomic]]
[[Category: Ebola]]
[[Category: Nucleoprotein]]
[[Category: Seattle structural genomics center for infectious disease]]
[[Category: Smt]]
[[Category: Ssgcid]]
[[Category: Transcription]]
[[Category: Vp30]]

Latest revision as of 09:29, 22 October 2025

Crystal structure of the C-terminal domain of Ebola virus VP30 (strain Reston-89)

3v7o, resolution 2.25Å

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