1xhc: Difference between revisions
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New page: left|200px<br /><applet load="1xhc" size="450" color="white" frame="true" align="right" spinBox="true" caption="1xhc, resolution 2.350Å" /> '''NADH oxidase /nitri... |
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== | ==NADH oxidase /nitrite reductase from Pyrococcus furiosus Pfu-1140779-001== | ||
<StructureSection load='1xhc' size='340' side='right'caption='[[1xhc]], [[Resolution|resolution]] 2.35Å' scene=''> | |||
[[ | == Structural highlights == | ||
[[ | <table><tr><td colspan='2'>[[1xhc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_furiosus_DSM_3638 Pyrococcus furiosus DSM 3638]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XHC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XHC FirstGlance]. <br> | ||
[[ | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35Å</td></tr> | ||
[[ | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xhc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xhc OCA], [https://pdbe.org/1xhc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xhc RCSB], [https://www.ebi.ac.uk/pdbsum/1xhc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xhc ProSAT]</span></td></tr> | |||
[ | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/NROR_PYRFU NROR_PYRFU] Catalyzes the NADH-dependent reduction of rubredoxin (Rd), a small iron-containing redox protein (PubMed:10464233, PubMed:11398485, PubMed:15746356). Can also reduce other electron carriers, including 2,6-dichlorophenol indophenol, benzyl viologen and menadione, but rubredoxin is the most efficient electron acceptor (PubMed:10464233, PubMed:11398485, PubMed:15746356). Does not reduce ferredoxin (PubMed:10464233). Shows comparable activity with NADPH and NADH as electron donors, but NADPH is probably the preferred physiological electron donor (PubMed:10464233, PubMed:11398485). Is probably part of an oxygen detoxification system that protects P.furiosus during exposure to oxygen (PubMed:15746356).<ref>PMID:10464233</ref> <ref>PMID:11398485</ref> <ref>PMID:15746356</ref> | |||
[[ | == Evolutionary Conservation == | ||
[ | [[Image:Consurf_key_small.gif|200px|right]] | ||
[ | Check<jmol> | ||
[[Category: | <jmolCheckbox> | ||
[[Category: | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xh/1xhc_consurf.spt"</scriptWhenChecked> | ||
[[Category: | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
[[Category: | <text>to colour the structure by Evolutionary Conservation</text> | ||
[[Category: | </jmolCheckbox> | ||
[[Category: | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xhc ConSurf]. | ||
[[Category: | <div style="clear:both"></div> | ||
[[Category: | == References == | ||
[[Category: | <references/> | ||
[[Category: | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Pyrococcus furiosus DSM 3638]] | ||
[[Category: | [[Category: Adams MWW]] | ||
[[Category: | [[Category: Arendall III WB]] | ||
[[Category: | [[Category: Brereton PS]] | ||
[[Category: | [[Category: Chen L]] | ||
[[Category: | [[Category: Horanyi P]] | ||
[[Category: | [[Category: Izumi M]] | ||
[[Category: | [[Category: Jenney Jr FE]] | ||
[[Category: Lee D]] | |||
[[Category: Liu Z-J]] | |||
[[Category: Poole II FL]] | |||
[[Category: Richardson DC]] | |||
[[Category: Richardson JS]] | |||
[[Category: Rose JP]] | |||
[[Category: Shah A]] | |||
[[Category: Shah C]] | |||
[[Category: Sugar FJ]] | |||
[[Category: Tempel W]] | |||
[[Category: Wang B-C]] | |||
[[Category: Weinberg MV]] | |||
Latest revision as of 06:45, 23 August 2023
NADH oxidase /nitrite reductase from Pyrococcus furiosus Pfu-1140779-001
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