3lmk: Difference between revisions
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< | ==Ligand Binding Domain of Metabotropoc glutamate receptor mGluR5 complexed with glutamate== | ||
<StructureSection load='3lmk' size='340' side='right'caption='[[3lmk]], [[Resolution|resolution]] 2.44Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3lmk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LMK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LMK FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.44Å</td></tr> | |||
--> | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3lmk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lmk OCA], [https://pdbe.org/3lmk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3lmk RCSB], [https://www.ebi.ac.uk/pdbsum/3lmk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3lmk ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/GRM5_HUMAN GRM5_HUMAN] Receptor for glutamate. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lm/3lmk_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3lmk ConSurf]. | |||
<div style="clear:both"></div> | |||
=== | ==See Also== | ||
*[[Metabotropic glutamate receptor 3D structures|Metabotropic glutamate receptor 3D structures]] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Arrowsmith | [[Category: Large Structures]] | ||
[[Category: Bochkarev | [[Category: Arrowsmith CH]] | ||
[[Category: Bountra | [[Category: Bochkarev A]] | ||
[[Category: Cossar | [[Category: Bountra C]] | ||
[[Category: Dobrovetsky | [[Category: Cossar D]] | ||
[[Category: Edwards | [[Category: Dobrovetsky E]] | ||
[[Category: Khutoreskaya | [[Category: Edwards AM]] | ||
[[Category: Khutoreskaya G]] | |||
[[Category: Seitova | [[Category: Seitova A]] | ||
[[Category: Weigelt | [[Category: Weigelt J]] | ||
Latest revision as of 10:08, 6 November 2024
Ligand Binding Domain of Metabotropoc glutamate receptor mGluR5 complexed with glutamate
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