2xdc: Difference between revisions
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New page: '''Unreleased structure''' The entry 2xdc is ON HOLD Authors: Hoefer, N., Aragao, D., Caffrey, M.D. Description: Structure of linear gramicidin D obtained using Type I crystals grown i... |
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==Structure of linear gramicidin D obtained using Type I crystals grown in a lipid cubic phase.== | |||
<StructureSection load='2xdc' size='340' side='right'caption='[[2xdc]], [[Resolution|resolution]] 1.70Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2xdc]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Brevibacillus_brevis Brevibacillus brevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XDC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XDC FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=15P:POLYETHYLENE+GLYCOL+(N=34)'>15P</scene>, <scene name='pdbligand=DLE:D-LEUCINE'>DLE</scene>, <scene name='pdbligand=DVA:D-VALINE'>DVA</scene>, <scene name='pdbligand=ETA:ETHANOLAMINE'>ETA</scene>, <scene name='pdbligand=FVA:N-FORMYL-L-VALINE'>FVA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PRD_000150:GRAMICIDIN+A'>PRD_000150</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xdc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xdc OCA], [https://pdbe.org/2xdc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xdc RCSB], [https://www.ebi.ac.uk/pdbsum/2xdc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xdc ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Structure determination of membrane proteins by crystallographic means has been facilitated by crystallization in lipidic mesophases. It has been suggested, however, that this so-called in meso method, as originally implemented, would not apply to small protein targets having </=4 transmembrane crossings. In our study, the hypothesis that the inherent flexibility of the mesophase would enable crystallogenesis of small proteins was tested using a transmembrane pentadecapeptide, linear gramicidin, which produced structure-grade crystals. This result suggests that the in meso method should be considered as a viable means for high-resolution structure determination of integral membrane peptides, many of which are predicted to be coded for in the human genome. | |||
Crystallizing transmembrane peptides in lipidic mesophases.,Hofer N, Aragao D, Caffrey M Biophys J. 2010 Aug 4;99(3):L23-5. PMID:20682243<ref>PMID:20682243</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 2xdc" style="background-color:#fffaf0;"></div> | |||
==See Also== | |||
*[[Gramicidin|Gramicidin]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Brevibacillus brevis]] | |||
[[Category: Large Structures]] | |||
[[Category: Aragao D]] | |||
[[Category: Caffrey M]] | |||
[[Category: Hoefer N]] | |||
Latest revision as of 05:35, 17 October 2024
Structure of linear gramicidin D obtained using Type I crystals grown in a lipid cubic phase.
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