Gelsolin: Difference between revisions

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New page: left|200px <!-- {{Structure |PDB=3ffn|SIZE=350|SCENE=|CAPTION=Gelsolin (GLS), 3FFN |SITE= |LIGAND= |ACTIVITY= |GENE= |DOMAIN= |RELATEDENTRY= |RESOURCES= }} --> {{STRUCTU...
 
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<StructureSection load='1h1v' size='350' side='right' caption='Human gelsolin S4-S6 (gold) complex with actin (cyan), ATP and Ca+2 ion (green)  (PDB entry [[1h1v]])' scene='41/410297/Cv/3'>
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__TOC__
{{Structure
== Function ==
|PDB=3ffn|SIZE=350|SCENE=|CAPTION=Gelsolin (GLS), 3FFN
|SITE=
|LIGAND=
|ACTIVITY=
|GENE=
|DOMAIN=
|RELATEDENTRY=
|RESOURCES=
}}
-->
{{STRUCTURE_3ffn|  PDB=3ffn  |  SCENE= |CAPTION=Gelsolin (GLS), [[3ffn]] }}


'''3D Structure of Gelsolin''' <br />
[[Gelsolin]] (GLS) is a protein regulator of actin assembly and disassembly<ref>PMID:10559185</ref>.  Binding of Ca+2 ion to GLS induces conformational change which enables it to bind actin.


== Structural highlights ==


== Actin Binding Protein ==
GLS contains 6 homologous domains S1 to S6.  The human GLS domains span residues: 15-135, 136-248, 249-367, 394-513, 514-619 and 620-734. <scene name='41/410297/Cv/6'>S4-S6 are shown</scene>.  The <scene name='41/410297/Cv/7'>binding site of Ca+2 ion includes Glu, Asp and 2 carbonyl oxygens</scene><ref>PMID:12460571</ref>.


Gelsolin (GLS) is a protein regulator of actin assembly and disassembly.  It contains 6 homologous domains S1 to S6.
== 3D Structures of gelsolin ==
[[Gelsolin 3D structures]]


== 3D Structures of SOD ==
</StructureSection>


 
== References ==
=== GLS ===
<references/>
 
[[Category:Topic Page]]
 
[[3ffn]] – hGLS – human <br />
[[2fgh]] – hoGLS+ATP – horse <br />
[[1d0n]] - hoGLS <br />
 
 
=== GLS domains S1-S3 ===
 
 
[[3ffk]] – hGLS domains S1-S3+actin <br />
[[1rgi]] - hoGLS domains S1-S3+actin <br />
 
 
=== GLS domains S4-S6 ===
 
 
[[1h1v]] - hGLS domains S4-S6+actin<br />
[[1nph]] - GLS domains S4-S6+Ca – mouse<br />
 
 
=== GLS domain S1 ===
 
 
[[2ff3]] - hGLS domain S1+N-WASP+actin<br />
[[2ff6]] - hGLS domain S1+Ciboulot domain 2+actin<br />
[[1mdu]] - hGLS domain S1+chActin – chicken<br />
[[1d4x]] - hGLS domain S1+CeActin+Mg-ATP – Caenorhabditis elegans<br />
[[1esv]] - hGLS domain S1+rActin+latrunculin – rabbit<br />
[[1eqy]] - hGLS domain S1+rActin<br />
[[1yvn]] - hGLS domain S1+yActin (mutant) – yeast<br />
[[1yag]] - hGLS domain S1+yActin<br />
[[1kcq]] – hGLS domainS1+Cd<br />
[[1c0f]] - hGLS domain S1+DdActin+Ca-ATP - Dictyostelium discoideum<br />
[[1c0g]], [[1dej]] - hGLS domain S1+DdActin (mutant)<br />
[[3ci5]], [[3cip]], [[1nlv]] – DdGLS domain S1+actin<br />
[[1nm1]] - DdGLS domain S1+actin+Mg-ATP<br />
[[3cjb]] - rGLS domain S1+rActin<br />
[[3cjc]] - rGLS domain S1+rActin+DNAse I<br />
[[1nmd]] - hGLS domain S1+actin+Ca+ATP<br />
 
 
=== GLS C-terminal ===
 
 
[[2fh1]], [[2fh2]], [[2fh3]], [[2fh4]] – hGLS C-terminal<br />
[[1p8x]] - hGLS C-terminal+Ca<br />
[[1p8z]] – hGLS fraction+rActin<br />

Latest revision as of 11:01, 26 October 2020

Human gelsolin S4-S6 (gold) complex with actin (cyan), ATP and Ca+2 ion (green) (PDB entry 1h1v)

Drag the structure with the mouse to rotate

References

Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Jaime Prilusky, Michal Harel

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