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| [[Image:3ffn.jpg|left|200px]]
| | <StructureSection load='1h1v' size='350' side='right' caption='Human gelsolin S4-S6 (gold) complex with actin (cyan), ATP and Ca+2 ion (green) (PDB entry [[1h1v]])' scene='41/410297/Cv/3'> |
| <!-- | | __TOC__ |
| {{Structure
| | == Function == |
| |PDB=3ffn|SIZE=350|SCENE=|CAPTION=Gelsolin (GLS), 3FFN
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| |SITE=
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| |LIGAND=
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| |ACTIVITY=
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| |GENE=
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| |DOMAIN=
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| |RELATEDENTRY=
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| |RESOURCES=
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| }}
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| -->
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| {{STRUCTURE_3ffn| PDB=3ffn | SCENE=Gelsolin/Cv/1 |CAPTION=Gelsolin (GLS), [[3ffn]] }}
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| '''3D Structure of Gelsolin''' <br />
| | [[Gelsolin]] (GLS) is a protein regulator of actin assembly and disassembly<ref>PMID:10559185</ref>. Binding of Ca+2 ion to GLS induces conformational change which enables it to bind actin. |
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| | == Structural highlights == |
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| == Actin Binding Protein == | | GLS contains 6 homologous domains S1 to S6. The human GLS domains span residues: 15-135, 136-248, 249-367, 394-513, 514-619 and 620-734. <scene name='41/410297/Cv/6'>S4-S6 are shown</scene>. The <scene name='41/410297/Cv/7'>binding site of Ca+2 ion includes Glu, Asp and 2 carbonyl oxygens</scene><ref>PMID:12460571</ref>. |
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| Gelsolin (GLS) is a protein regulator of actin assembly and disassembly. It contains 6 homologous domains S1 to S6. The image at the right is a <scene name='Gelsolin/Cv/2'>dimer</scene> of the Gelsolin
| | == 3D Structures of gelsolin == |
| | [[Gelsolin 3D structures]] |
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| == 3D Structures of GLS ==
| | </StructureSection> |
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| | | == References == |
| === GLS ===
| | <references/> |
| | | [[Category:Topic Page]] |
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| [[3ffn]] – hGLS – human <br />
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| [[2fgh]] – hoGLS+ATP – horse <br />
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| [[1d0n]] - hoGLS <br />
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| === GLS domains S1-S3 ===
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| [[3ffk]] – hGLS domains S1-S3+actin <br />
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| [[1rgi]] - hoGLS domains S1-S3+actin <br />
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| === GLS domains S4-S6 ===
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| [[1h1v]] - hGLS domains S4-S6+actin<br />
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| [[1nph]] - GLS domains S4-S6+Ca – mouse<br />
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| === GLS domain S1 ===
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| [[2ff3]] - hGLS domain S1+N-WASP+actin<br />
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| [[2ff6]] - hGLS domain S1+Ciboulot domain 2+actin<br />
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| [[1mdu]] - hGLS domain S1+chActin – chicken<br />
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| [[1d4x]] - hGLS domain S1+CeActin+Mg-ATP – ''Caenorhabditis elegans''<br />
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| [[1esv]] - hGLS domain S1+rActin+latrunculin – rabbit<br />
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| [[1eqy]] - hGLS domain S1+rActin<br />
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| [[1yvn]] - hGLS domain S1+yActin (mutant) – yeast<br />
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| [[1yag]] - hGLS domain S1+yActin<br />
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| [[1kcq]] – hGLS domainS1+Cd<br />
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| [[1c0f]] - hGLS domain S1+DdActin+Ca-ATP - ''Dictyostelium discoideum''<br />
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| [[1c0g]], [[1dej]] - hGLS domain S1+DdActin (mutant)<br />
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| [[3ci5]], [[3cip]], [[1nlv]] – DdGLS domain S1+actin<br />
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| [[1nm1]] - DdGLS domain S1+actin+Mg-ATP<br />
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| [[3cjb]] - rGLS domain S1+rActin<br />
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| [[3cjc]] - rGLS domain S1+rActin+DNAse I<br />
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| [[1nmd]] - hGLS domain S1+actin+Ca+ATP<br />
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| === GLS C-terminal === | |
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| [[2fh1]], [[2fh2]], [[2fh3]], [[2fh4]] – hGLS C-terminal<br />
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| [[1p8x]] - hGLS C-terminal+Ca<br />
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| [[1p8z]] – hGLS fraction+rActin<br /> | |
