Concanavalin: Difference between revisions
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Eran Hodis (talk | contribs) New page: {{Stub}} See a structure for concanavalin A on the page for PDB entry 1scr. |
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<StructureSection load='1qdc' size='350' side='right' caption='Concanavalin A complex with trisacchride, Mn+2 (small purple), Cl- (large green) and Ca+2 (small green) ions (large purple) (PDB entry [[1qdc]])' scene='41/415806/Cv/1'> | |||
__TOC__ | |||
== Function == | |||
'''Concanavalin A''' (ConA) is a carbohydrate-binding protein from jack-bean (''Canavalia ensiformis''). It binds to certain sugars and to metal. It is used to characterize glycoproteins on cell surfaces.<ref>PMID:9546043</ref>. | |||
*'''Concanavalin B''' (ConB) is related to chitinase with 40% sequence identity.<ref>PMID:7490746</ref>. | |||
*'''Concanavalin BR''' (ConBR) is ConA from Brazilian jack bean. | |||
*'''Concanavalin V''' (ConV) is a D-mannose/D-glucose-binding lectin. | |||
== Relevance == | |||
ConA has therapeutic effect on liver cancer. | |||
== Structural highlights == | |||
ConA is the <scene name='41/415806/Cv/2'>homotetramer</scene> with D2 symmetry. ConA contains a <scene name='41/415806/Cv/7'>metal - Mn+2 and Ca+2 - binding site</scene> as well as a <scene name='41/415806/Cv/8'>sugar binding site</scene>. | |||
== 3D Structures of Concanavalin == | |||
[[Concanavalin 3D structures]] | |||
</StructureSection> | |||
== References == | |||
<references/> | |||
[[Category:Topic Page]] | |||
Latest revision as of 08:22, 6 February 2025
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References
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Alexander Berchansky, Eran Hodis, Jaime Prilusky
