2r6p: Difference between revisions

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New page: left|200px<br /><applet load="2r6p" size="350" color="white" frame="true" align="right" spinBox="true" caption="2r6p" /> '''Fit of E protein and Fab 1A1D-2 into 24 angs...
 
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[[Image:2r6p.jpg|left|200px]]<br /><applet load="2r6p" size="350" color="white" frame="true" align="right" spinBox="true"
caption="2r6p" />
'''Fit of E protein and Fab 1A1D-2 into 24 angstrom resolution cryoEM map of Fab complexed with dengue 2 virus.'''<br />


==About this Structure==
==Fit of E protein and Fab 1A1D-2 into 24 angstrom resolution cryoEM map of Fab complexed with dengue 2 virus.==
2R6P is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Dengue_virus_4 Dengue virus 4] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R6P OCA].  
<SX load='2r6p' size='340' side='right' viewer='molstar' caption='[[2r6p]], [[Resolution|resolution]] 24.00&Aring;' scene=''>
[[Category: Dengue virus 4]]
== Structural highlights ==
<table><tr><td colspan='2'>[[2r6p]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Dengue_virus_2_Puerto_Rico/PR159-S1/1969 Dengue virus 2 Puerto Rico/PR159-S1/1969] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. The July 2008 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Dengue Virus''  by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2008_7 10.2210/rcsb_pdb/mom_2008_7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R6P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2R6P FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 24&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2r6p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r6p OCA], [https://pdbe.org/2r6p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2r6p RCSB], [https://www.ebi.ac.uk/pdbsum/2r6p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2r6p ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q66394_9FLAV Q66394_9FLAV] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS011998_004_099774]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r6/2r6p_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2r6p ConSurf].
<div style="clear:both"></div>
__TOC__
</SX>
[[Category: Dengue Virus]]
[[Category: Dengue virus 2 Puerto Rico/PR159-S1/1969]]
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Protein complex]]
[[Category: RCSB PDB Molecule of the Month]]
[[Category: Chipman, P.R.]]
[[Category: Chipman PR]]
[[Category: Holdaway, H.A.]]
[[Category: Holdaway HA]]
[[Category: Kostyuchenko, V.K.]]
[[Category: Kostyuchenko VK]]
[[Category: Kuhn, R.J]]
[[Category: Kuhn RJ]]
[[Category: Lok, S.M.]]
[[Category: Lok SM]]
[[Category: Rossmann, M.G]]
[[Category: Rossmann MG]]
[[Category: dengue]]
[[Category: fab]]
[[Category: icosahedral virus]]
[[Category: neutralization]]
[[Category: virus]]
[[Category: virus/immune system complex]]
 
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Retrieved from "https://proteopedia.org/2r6p"