3pgd: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| (9 intermediate revisions by the same user not shown) | |||
| Line 1: | Line 1: | ||
==Crystal Structure of HLA-DR1 with CLIP106-120, canonical peptide orientation== | |||
<StructureSection load='3pgd' size='340' side='right'caption='[[3pgd]], [[Resolution|resolution]] 2.72Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3pgd]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PGD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PGD FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.72Å</td></tr> | |||
-- | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pgd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pgd OCA], [https://pdbe.org/3pgd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pgd RCSB], [https://www.ebi.ac.uk/pdbsum/3pgd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pgd ProSAT]</span></td></tr> | ||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
T-cell recognition of peptides bound to MHC class II (MHCII) molecules is a central event in cell-mediated adaptive immunity. The current paradigm holds that prebound class II-associated invariant chain peptides (CLIP) and all subsequent antigens maintain a canonical orientation in the MHCII binding groove. Here we provide evidence for MHCII-bound CLIP inversion. NMR spectroscopy demonstrates that the interconversion from the canonical to the inverse alignment is a dynamic process, and X-ray crystallography shows that conserved MHC residues form a hydrogen bond network with the peptide backbone in both orientations. The natural catalyst HLA-DM accelerates peptide reorientation and the exchange of either canonically or inversely bound CLIP against antigenic peptide. Thus, noncanonical MHC-CLIP displays the hallmarks of a structurally and functionally intact antigen-presenting complex. | |||
Bidirectional binding of invariant chain peptides to an MHC class II molecule.,Gunther S, Schlundt A, Sticht J, Roske Y, Heinemann U, Wiesmuller KH, Jung G, Falk K, Rotzschke O, Freund C Proc Natl Acad Sci U S A. 2010 Nov 29. PMID:21115828<ref>PMID:21115828</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 3pgd" style="background-color:#fffaf0;"></div> | |||
==See Also== | |||
*[[MHC 3D structures|MHC 3D structures]] | |||
*[[MHC II 3D structures|MHC II 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
== | </StructureSection> | ||
== | |||
< | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Falk | [[Category: Large Structures]] | ||
[[Category: Freund | [[Category: Falk K]] | ||
[[Category: Gunther | [[Category: Freund C]] | ||
[[Category: Heinemann | [[Category: Gunther S]] | ||
[[Category: Jung | [[Category: Heinemann U]] | ||
[[Category: Roske | [[Category: Jung G]] | ||
[[Category: Rotzschke | [[Category: Roske Y]] | ||
[[Category: Schlundt | [[Category: Rotzschke O]] | ||
[[Category: Sticht | [[Category: Schlundt A]] | ||
[[Category: Wiesmuller | [[Category: Sticht J]] | ||
[[Category: Wiesmuller K-H]] | |||
Latest revision as of 02:16, 21 November 2024
Crystal Structure of HLA-DR1 with CLIP106-120, canonical peptide orientation
| ||||||||||||
