Talin: Difference between revisions

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New page: left|200px|thumb|Crystal Structure of Talin [[2x0c]] {{STRUCTURE_2x0c| PDB=2x0c | SIZE=300| SCENE= |right|CAPTION=Talin 2x0c }} Talin is involved in cell-cell con...
 
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[[Image:2x0c.png|left|200px|thumb|Crystal Structure of Talin [[2x0c]]]]
<StructureSection load='' size='350' side='right' scene='Talin/Cv/1' caption='Talin rod domain residues 1359-1659 (PDB code [[2x0c]])'>
{{STRUCTURE_2x0c|  PDB=2x0c  | SIZE=300| SCENE= |right|CAPTION=Talin [[2x0c]] }}


Talin is involved in cell-cell contacts.  It links integrins to actin.  It contains a C-terminal rod domain with integrin binding sites (IBS) and actin binding sites (ABS) and N-terminal FERM domain with subdomains F0-F3.  The F3 subdomains interacts with integrin.  Talin contains 3 vinculin binding sites VBS1-VBS3.
[[Talin]] is involved in cell-cell contacts.  It links integrins to actin<ref>PMID:19416068</ref>.  It contains a C-terminal rod domain with integrin binding sites (IBS) and actin binding sites (ABS) and N-terminal FERM domain with subdomains F1-F3.  The F3 subdomain interacts with integrin.  Talin contains 3 [[Vinculin]] binding sites VBS1-VBS3.  
</StructureSection>
== 3D Structures of Talin ==
[[Talin 3D structures]]


Talin subdomains
== References ==
 
<references/>
2x0c, 2kbb, 3dyj, 1sj7, 1sj8 – mTal rod – mouse
</StructureSection>
2kma – mTal F0F1 – NMR
[[Category: Topic Page]]
2kc1 - mTal F0 – NMR
2kc2 - mTal F1 – NMR
2hrj - cTal F2 – NMR
1mix – cTal F2F3
2kgx – mTal F3+mTal fragment – NMR
 
Integrin binding sites
 
2jsw, 2qdq – mTal IBS – NMR
3g9w – mTal F2F3+integrin tail
1miz, 1mk7, 1mk9 - hTal+integrin tail
2h7d, 2h7e - cTal FERM F3+integrlin fragment – NMR
3fyq – Tal rod IBS2 – Drosophila melanogaster
 
Vinculin binding sites
 
2kvp, 2b0h – mTal VBS3 – NMR
1xwj, 1zvz, 1zw2, 1zw3 - cTal VBS3+ vinculin head – chicken
1u6h - cTal VBS2+ vinculin head
1t01 - cTal VBS1+ vinculin head
1syq - hTal VBS1+ vinculin head – human
1rkc - hTal VBS3+ vinculin head
1u89 - mTal VBS2 – NMR
 
PIP kinase binding sites
 
1y19 - mTal F2F3+ PIP kinase C-terminal
2g35 - mTal F3+PIP kinase peptide – NMR
 
Layilin binding sites
 
2k00 - cTal F3+layilin fragment – NMR

Latest revision as of 09:58, 12 December 2023

Talin rod domain residues 1359-1659 (PDB code 2x0c)

Drag the structure with the mouse to rotate

3D Structures of Talin

Vinculin

References

</StructureSection>

Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Joel L. Sussman, Michal Harel

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