Neurexin: Difference between revisions

Latest revision as of 08:30, 24 March 2026

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Glycosylated rat neurexin 1α LNS domain (cyan) complex with neuroligin-4 cholinesterase domain (pink), MES, ethylene glycol, Cl- and Ca+2 ions (PDB entry 2xb6)

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3D Structures of Neurexin

24-March-2026

References

Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Michal Harel, David Canner, Jaime Prilusky, Joel L. Sussman

[1] Dean C, Scholl FG, Choih J, DeMaria S, Berger J, Isacoff E, Scheiffele P. Neurexin mediates the assembly of presynaptic terminals. Nat Neurosci. 2003 Jul;6(7):708-16. PMID:12796785 doi:https://dx.doi.org/10.1038/nn1074

[2] Kim HG, Kishikawa S, Higgins AW, Seong IS, Donovan DJ, Shen Y, Lally E, Weiss LA, Najm J, Kutsche K, Descartes M, Holt L, Braddock S, Troxell R, Kaplan L, Volkmar F, Klin A, Tsatsanis K, Harris DJ, Noens I, Pauls DL, Daly MJ, MacDonald ME, Morton CC, Quade BJ, Gusella JF. Disruption of neurexin 1 associated with autism spectrum disorder. Am J Hum Genet. 2008 Jan;82(1):199-207. doi: 10.1016/j.ajhg.2007.09.011. PMID:18179900 doi:https://dx.doi.org/10.1016/j.ajhg.2007.09.011

[3] Leone P, Comoletti D, Ferracci G, Conrod S, Garcia SU, Taylor P, Bourne Y, Marchot P. Structural insights into the exquisite selectivity of neurexin/neuroligin synaptic interactions. EMBO J. 2010 Jul 21;29(14):2461-71. Epub 2010 Jun 11. PMID:20543817 doi:10.1038/emboj.2010.123

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-[[Image:3bod.png|left|200px|thumb|Crystal Structure of mouse β-neurexin 1 [[3bod]]]]
+<StructureSection load='' size='350' side='right' caption='Glycosylated rat neurexin 1α LNS domain (cyan) complex with neuroligin-4 cholinesterase domain (pink), MES, ethylene glycol, Cl- and Ca+2 ions (PDB entry [[2xb6]])' scene='42/424006/Cv/2'>
-{{STRUCTURE_3bod|  PDB=3bod  | SIZE=300| SCENE=Neurexin/Cv/1 |right|CAPTION=Mouse β-neurexin 1 [[3bod]] }}
+__TOC__
+== Function ==
+[[Neurexin|Neurexins]] (NRXN) are a family of presynaptic proteins which bind to the postsynaptic [[Neuroligin]] (NLGN) to form a complex which attaches neurons.  The NRXN family contains 4 members which are numbered 1 to 4<ref>PMID:12796785</ref>.  The NRXN-α contains 6 homologous LNS domains while the NRXN-β contains only LNS6.
-[[Neurexin|Neurexins]] (NRXN) are a family of presynaptic proteins which bind to the postsynaptic [[Neuroligin]] (NLGN) to form a complex which attaches neurons.  The NRXN family contains 4 members which are numbered 1 to 4.  The α-NRXN contains 6 homologous LNS domains while the β-NRXN contains only LNS6. The images at the left and at the right correspond to one representative NRXN, ''i.e.'' the crystal structure of mouse β-neurexin 1 ([[3bod]]).
+See: [[Neurodevelopmental Disorders]]<br />
+[[Neuroligin-Neurexin Interaction]]
-{{TOC limit|limit=2}}
+== Relevance ==
+NRXN sequence variants may contribute to autism spectrum disorder and other cognitive diseases<ref>PMID:18179900</ref>.
-== 3D Structures of Neurexin ==
+== Structural highlights ==
+The <scene name='42/424006/Cv/7'>surface interaction between NRXN and neuroligin</scene> is mediated by a <scene name='42/424006/Cv/8'>Ca+2 ion</scene><ref>PMID:20543817</ref>. Water molecules are shown as red spheres.
+</StructureSection>
-=== α-NRXN ===
+== 3D Structures of Neurexin ==
-[[2h0b]] -  bα-NRXN-1 LNS2 – bovine<br />
-[[2r16]] - bα-NRXN-1 LNS 4<br />
-=== β-NRXN ===
-[[3mw2]] – mβ-NRXN-1 +splice insert 4 – mouse<br />
-[[3bod]] -  mβ-NRXN-1<br />
-[[3bop]] - mβ-NRXN-2d4<br />
-[[3mw3]], [[2r1b]] - rβ-NRXN-2 +splice insert 4 – rat<br />
-[[2r1b]] - rβ-NRXN-1 +splice insert 4<br />
-[[2r1d]] - rβ-NRXN-1 +Ca<br />
-[[1c4r]] -  rβ-NRXN-1<br />
-[[3mw4]] -  mβ-NRXN-3<br />
+{{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+{{#tree:id=OrganizedByTopic|openlevels=0|
+*Neurexin
-=== NRXN+NLGN ===
+**[[5z8y]] – hNRXN-1b + LRRTM2 – human<br />
+**[[3mw2]] – mNRXN-1α LNS domain+splice insert 4 – mouse<br />
+**[[3bod]], [[3bop]] -  mβNRXN-1 residues 1132-1246 + mb-NRXN-2 residues 1277-1334<br />
+**[[3mw4]] -  mβNRXN-3 residues 854-1027<br />
+**[[6pnp]], [[6pnq]] - mNRXN-1 LNS2 domain + neurexophilin-1<br />
+**[[2r1b]], [[3mw3]] - rNRXN-1α LNS domain+splice insert 4 – rat<br />
+**[[2r16]] - rNRXN-1α LNS domain+Ca<br />
+**[[1c4r]] -  rNRXN-1α LNS domain<br />
+**[[2r1d]] - rNRXN-1β LNS/LG domain<br />
+**[[2h0b]] -  bNRXN-1α LNS2 domain – bovine<br />
+**[[6cw1]] - bNRXN-1 LNS2-LNS3 domains<br />
+**[[3asi]] - bNRXN-1α LNS5-EGF3-LNS6 domains<br />
+**[[3poy]] - bNRXN-1α LNS2-LNS6 domains (mutant)<br />
+**[[3qcw]], [[3r05]] - bNRXN-1α LNS1-LNS6 domains (mutant)<br />
-[[2xb6]], [[2wqz]] – rβ-NRXN-1 +hNLGN-4 cholinesterase domain<br />
+*NRXN+Neuroligin
-[[3b3q]] -  hNRXN-1 LNS domain+mNLGN-1 cholinesterase domain<br />
-[[3biw]] -  rβ-NRXN-1 +rNLGN-1 cholinesterase domain<br />
+**[[2wqz]], [[2xb6]] – rNRXN-1α LNS domain +hNLGN-4 cholinesterase domain<br />
+**[[3b3q]] -  hNRXN-1α LNS domain+mNLGN-4 cholinesterase domain<br />
+**[[3biw]] -  rNRXN-1α LNS domain+rNLGN-1 cholinesterase domain<br />
+**[[3vkf]] - bNRXN-1β LNS domain+rNLGN-1 cholinesterase domain
+**[[8g7y]], [[8g7z]], [[8g80]], [[8g81]] - mNRXN-1β + mNLGN-2 – Cryo EM
+}}
+== References ==
+<references/>
 [[Category:Topic Page]]

Neurexin: Difference between revisions

Latest revision as of 08:30, 24 March 2026

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Function

Relevance

Structural highlights

3D Structures of Neurexin

References

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