2xk0: Difference between revisions

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[[Image:2xk0.png|left|200px]]


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==Solution structure of the Tudor domain from Drosophila Polycomblike (Pcl)==
The line below this paragraph, containing "STRUCTURE_2xk0", creates the "Structure Box" on the page.
<StructureSection load='2xk0' size='340' side='right'caption='[[2xk0]]' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2xk0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XK0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XK0 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xk0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xk0 OCA], [https://pdbe.org/2xk0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xk0 RCSB], [https://www.ebi.ac.uk/pdbsum/2xk0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xk0 ProSAT]</span></td></tr>
{{STRUCTURE_2xk0|  PDB=2xk0  |  SCENE=  }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/PCL_DROME PCL_DROME]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xk/2xk0_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2xk0 ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Posttranslational modifications of histone tails are among the most prominent epigenetic marks and play a critical role in transcriptional control at the level of chromatin. The Polycomblike (Pcl) protein is part of a histone methyltransferase complex (Pcl-PRC2) responsible for high levels of histone H3 K27 trimethylation. Studies in Drosophila larvae suggest that Pcl is required for anchoring Pcl-PRC2 at target genes, but how this is achieved is unknown. Pcl comprises a Tudor domain and two PHD fingers. These domains are known to recognize methylated lysine or arginine residues and could contribute to targeting of Pcl-PRC2.Here, we report an NMR structure of the Tudor domain from Drosophila Pcl (Pcl-Tudor) and binding studies with putative ligands. Pcl-Tudor contains an atypical, incomplete aromatic cage that does not interact with known Tudor domain ligands, such as methylated lysines or arginines. Interestingly, human Pcl orthologs exhibit a complete aromatic cage, suggesting that they may recognize methylated lysines. Structural comparison with other Tudor domains suggests that Pcl-Tudor may engage in intra- or intermolecular interactions through an exposed hydrophobic surface patch.


===SOLUTION STRUCTURE OF THE TUDOR DOMAIN FROM DROSOPHILA POLYCOMBLIKE (PCL)===
Structure of an atypical Tudor domain in the Drosophila Polycomblike protein.,Friberg A, Oddone A, Klymenko T, Muller J, Sattler M Protein Sci. 2010 Jul 28. PMID:20669242<ref>PMID:20669242</ref>


From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 2xk0" style="background-color:#fffaf0;"></div>


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==See Also==
The line below this paragraph, {{ABSTRACT_PUBMED_20669242}}, adds the Publication Abstract to the page
*[[Polycomb complex proteins 3D structures|Polycomb complex proteins 3D structures]]
(as it appears on PubMed at http://www.pubmed.gov), where 20669242 is the PubMed ID number.
== References ==
-->
<references/>
{{ABSTRACT_PUBMED_20669242}}
__TOC__
 
</StructureSection>
==About this Structure==
[[2xk0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XK0 OCA].
 
==Reference==
<ref group="xtra">PMID:20669242</ref><references group="xtra"/>
[[Category: Drosophila melanogaster]]
[[Category: Drosophila melanogaster]]
[[Category: Friberg, A.]]
[[Category: Large Structures]]
[[Category: Klymenko, T.]]
[[Category: Friberg A]]
[[Category: Mueller, J.]]
[[Category: Klymenko T]]
[[Category: Oddone, A.]]
[[Category: Mueller J]]
[[Category: Sattler, M.]]
[[Category: Oddone A]]
[[Category: Aromatic cage]]
[[Category: Sattler M]]
[[Category: Transcription]]

Latest revision as of 05:59, 19 June 2024

Solution structure of the Tudor domain from Drosophila Polycomblike (Pcl)

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