3q3j: Difference between revisions

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New page: '''Unreleased structure''' The entry 3q3j is ON HOLD Authors: Wang, H., Tempel, W., Tong, Y., Guan, X., Shen, L., Buren, L., Zhang, N., Wernimont, A.K., Crombet, L., Arrowsmith, C.H., E...
 
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'''Unreleased structure'''


The entry 3q3j is ON HOLD
==Crystal structure of plexin A2 RBD in complex with Rnd1==
<StructureSection load='3q3j' size='340' side='right'caption='[[3q3j]], [[Resolution|resolution]] 1.97&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3q3j]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q3J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3Q3J FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.971&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3q3j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q3j OCA], [https://pdbe.org/3q3j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3q3j RCSB], [https://www.ebi.ac.uk/pdbsum/3q3j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3q3j ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PLXA2_HUMAN PLXA2_HUMAN] Coreceptor for SEMA3A and SEMA6A. Necessary for signaling by SEMA6A and class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity).


Authors: Wang, H., Tempel, W., Tong, Y., Guan, X., Shen, L., Buren, L., Zhang, N., Wernimont, A.K., Crombet, L., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Park, H., Structural Genomics Consortium (SGC)
==See Also==
 
*[[GTP-binding protein 3D structures|GTP-binding protein 3D structures]]
Description: Crystal structure of plexin A2 RBD in complex with Rnd1
*[[Plexin 3D structures|Plexin 3D structures]]
*[[Rho GTPase 3D structures|Rho GTPase 3D structures]]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Arrowsmith CH]]
[[Category: Bountra C]]
[[Category: Buren L]]
[[Category: Crombet L]]
[[Category: Edwards AM]]
[[Category: Guan X]]
[[Category: Park H]]
[[Category: Shen L]]
[[Category: Tempel W]]
[[Category: Tong Y]]
[[Category: Wang H]]
[[Category: Weigelt J]]
[[Category: Wernimont AK]]
[[Category: Zhang N]]
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