3ngg: Difference between revisions

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[[Image:3ngg.png|left|200px]]


<!--
==X-ray Structure of Omwaprin==
The line below this paragraph, containing "STRUCTURE_3ngg", creates the "Structure Box" on the page.
<StructureSection load='3ngg' size='340' side='right'caption='[[3ngg]], [[Resolution|resolution]] 1.33&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3ngg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Oxyuranus_microlepidotus Oxyuranus microlepidotus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NGG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NGG FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.33&#8491;</td></tr>
-->
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ngg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ngg OCA], [https://pdbe.org/3ngg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ngg RCSB], [https://www.ebi.ac.uk/pdbsum/3ngg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ngg ProSAT]</span></td></tr>
{{STRUCTURE_3ngg|  PDB=3ngg  |  SCENE=  }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/WAPA_OXYMI WAPA_OXYMI]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ng/3ngg_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ngg ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The 50-residue snake venom protein L-omwaprin and its enantiomer D-omwaprin were prepared by total chemical synthesis. Radial diffusion assays were performed against Bacillus megaterium and Bacillus anthracis; both L-omwaprin and D-omwaprin showed anti-bacterial activity against B. megaterium. The native protein enantiomer, made of L- amino acids, failed to crystallize readily. However, when a racemic mixture containing equal amounts of L-omwaprin and D-omwaprin was used, diffraction quality crystals were obtained. The racemic protein sample crystallized in the centrosymmetric space group P2(1)/c and its structure was determined at atomic resolution (1.33 A) by a combination of Patterson and direct methods based on the strong scattering from the sulfur atoms in the eight cysteine residues per protein. Racemic crystallography once again proved to be a valuable method for obtaining crystals of recalcitrant proteins, and for determining high resolution X-ray structures by direct methods.


===X-ray Structure of Omwaprin===
Determination of the X-ray structure of the snake venom protein omwaprin by total chemical synthesis and racemic protein crystallography.,Banigan JR, Mandal K, Sawaya MR, Thammavongsa V, Hendrickx AP, Schneewind O, Yeates TO, H Kent SB Protein Sci. 2010 Jul 28. PMID:20669184<ref>PMID:20669184</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
<!--
</div>
The line below this paragraph, {{ABSTRACT_PUBMED_20669184}}, adds the Publication Abstract to the page
<div class="pdbe-citations 3ngg" style="background-color:#fffaf0;"></div>
(as it appears on PubMed at http://www.pubmed.gov), where 20669184 is the PubMed ID number.
== References ==
-->
<references/>
{{ABSTRACT_PUBMED_20669184}}
__TOC__
 
</StructureSection>
==About this Structure==
[[Category: Large Structures]]
[[3ngg]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NGG OCA].
[[Category: Oxyuranus microlepidotus]]
 
[[Category: Banigan JR]]
==Reference==
[[Category: Hendrickx APA]]
<ref group="xtra">PMID:20669184</ref><references group="xtra"/>
[[Category: Kent SBH]]
[[Category: Banigan, J R.]]
[[Category: Mandal K]]
[[Category: Hendrickx, A P.A.]]
[[Category: Sawaya MR]]
[[Category: Kent, S B.H.]]
[[Category: Schneewind O]]
[[Category: Mandal, K.]]
[[Category: Thammavongsa V]]
[[Category: Sawaya, M R.]]
[[Category: Yeates TO]]
[[Category: Schneewind, O.]]
[[Category: Thammavongsa, V.]]
[[Category: Yeates, T O.]]

Latest revision as of 08:04, 9 October 2024

X-ray Structure of Omwaprin

3ngg, resolution 1.33Å

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