3q4t: Difference between revisions
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New page: '''Unreleased structure''' The entry 3q4t is ON HOLD Authors: Chaikuad, A., Alfano, I., Mahajan, P., Cooper, C.D.O., Sanvitale, C., Vollmar, M., Krojer, T., Muniz, J.R.C., Raynor, J., v... |
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==Crystal structure of Activin receptor type-IIA (ACVR2A) kinase domain in complex with dorsomorphin== | |||
<StructureSection load='3q4t' size='340' side='right'caption='[[3q4t]], [[Resolution|resolution]] 1.96Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3q4t]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q4T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3Q4T FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.96Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TAK:6-[4-(2-PIPERIDIN-1-YLETHOXY)PHENYL]-3-PYRIDIN-4-YLPYRAZOLO[1,5-A]PYRIMIDINE'>TAK</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3q4t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q4t OCA], [https://pdbe.org/3q4t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3q4t RCSB], [https://www.ebi.ac.uk/pdbsum/3q4t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3q4t ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/AVR2A_HUMAN AVR2A_HUMAN] On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Alfano I]] | |||
[[Category: Arrowsmith CH]] | |||
[[Category: Bountra C]] | |||
[[Category: Bullock A]] | |||
[[Category: Chaikuad A]] | |||
[[Category: Cooper CDO]] | |||
[[Category: Edwards AM]] | |||
[[Category: Krojer T]] | |||
[[Category: Mahajan P]] | |||
[[Category: Muniz JRC]] | |||
[[Category: Raynor J]] | |||
[[Category: Sanvitale C]] | |||
[[Category: Vollmar M]] | |||
[[Category: Weigelt J]] | |||
[[Category: Von Delft F]] | |||
Latest revision as of 11:33, 14 March 2024
Crystal structure of Activin receptor type-IIA (ACVR2A) kinase domain in complex with dorsomorphin
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