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[[Image:3pyc.jpg|left|200px]]


<!--
==Crystal structure of human SMURF1 C2 domain==
The line below this paragraph, containing "STRUCTURE_3pyc", creates the "Structure Box" on the page.
<StructureSection load='3pyc' size='340' side='right'caption='[[3pyc]], [[Resolution|resolution]] 1.96&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3pyc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PYC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PYC FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.96&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
{{STRUCTURE_3pyc|  PDB=3pyc  |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pyc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pyc OCA], [https://pdbe.org/3pyc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pyc RCSB], [https://www.ebi.ac.uk/pdbsum/3pyc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pyc ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SMUF1_HUMAN SMUF1_HUMAN] E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA.<ref>PMID:10458166</ref> <ref>PMID:19937093</ref> <ref>PMID:21402695</ref>


===Crystal structure of human SMURF1 C2 domain===
==See Also==
 
*[[Ubiquitin protein ligase 3D structures|Ubiquitin protein ligase 3D structures]]
 
== References ==
==About this Structure==
<references/>
[[3pyc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PYC OCA].
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Li, P.]]
[[Category: Large Structures]]
[[Category: Li, X.]]
[[Category: Li P]]
[[Category: Li X]]

Latest revision as of 13:35, 1 March 2024

Crystal structure of human SMURF1 C2 domain

3pyc, resolution 1.96Å

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