Ubiquitin protein ligase 3D structures

3D Structures of ubiquitin protein ligase

Updated on 31-July-2024 - For a general description of the protein see Ubiquitin protein ligase

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• Ubiquitin protein ligase AMFR
  • 4g3o – hUPL CUE domain - human
    
  • 2lvn – hUPL CUE domain - NMR
    
  • 2lxh – hUPL RING domain - NMR
    
  • 2lvo, 2lvp, 2lvq – hUPL CUE domain + ubiquitin - NMR
    
  • 2lxp – hUPL RING+G2BR domains + E2 G2 - NMR
    
  • 4lad – hUPL RING domain (mutant) + E2 G2
    
• Ubiquitin protein ligase ARIH1 Domains: catalytic 325-396
  • 4kbl, 4kc9 – hUPL
    
  • 2m9y – hUPL catalytic domain - NMR
    
  • 5udh, 5tte – hUPL + E2 L3 + ubiquitin
    
  • 7b5m, 7b5n, 7b5s – hUPL + UPL RBX1 + Cul1 – Cryo EM
    
  • 7b5l – hUPL in E3 super assembly – Cryo EM
    
• Ubiquitin protein ligase ARIH2
  • 7od1 – hUPL
    
  • 7oni – hUPL + UPL RBX2 + Cul5 + NEDD8 – Cryo EM
    
• Ubiquitin protein ligase Arkadia
  • 2kiz – hUPL RING domain - NMR
    
  • 5lg0, 5lg7, 7p2k – hUPL RING domain (mutant) - NMR
    
• Ubiquitin protein ligase Bard or BRCA1-associated ring domain protein
  • 7e8i, 7jzv, 7lyb, 7lyc, 8grq – hUPL 1 RING domain 26-122 in nucleosome – Cryo EM
    
  • 6m14 – hUPL 1 residues 568-777
    
• 'Ubiquitin protein ligase BIRC or baculoviral IAP repeat containing protein’ ;Domains: BIR1 26-102; BIR2 175-256; BIR3 261-346
  • 6w74 – hCIAP 2 260-352 + inhibitor
    
  • 7qgj – hCIAP 2 BIR2 domain
    
  • 6exw, 7trm, 8dsf – hCIAP 2 BIR3 domain + inhibitor
    
  • 7trl – hCIAP 2 BIR3 domain + histone H3
    
  • 6w7o, 6w8i, 8dso – hCIAP 2 384-659 + BTK + inhibitor
    
  • 6hpr – hCIAP 2 556-618 + E2 D2 + polyubiquitin-B
    
  • 7nk0 – hCIAP 3 BIR1 domain
    
  • 8e2d, 8e2e, 8e2f, 8e2g – hCIAP 6 – Cryo EM
    
  • 8auk, 8e2k – hCIAP 6 + HtrA2 – Cryo EM
    
  • 8e2i – hCIAP 6 + Diablo IAP-binding protein – Cryo EM
    
• Ubiquitin protein ligase Bre1
  • 5trb – hUPL RNF20 domain 906-975
    
  • 4r7e – hUPL RING domain 632-700
    
  • 8gui, 8guj, 8t3t, 8t3w, 8t3y – hUPL RING domain in nucleosome – Cryo EM
    
  • 8ieg, 8iej – hUPL 1A 915-974 + UPL 1B 941-1000 in nucleosome – Cryo EM
    
  • 7uv8, 7uvc – hUPL 1 residues 1-212 + E2 2
    
  • 7w75, 7w76 – UPL RBD 1-206 + Rad6 – Kluyveromyces lactis<br />
• Ubiquitin protein ligase Cbl Domains:Tyr kinase-binding (TKB) 25-351;RING 358-437;WW3 399-432;catalytic 495-852; UBA 924-973-432
  • 2y1m – hUPL
    
  • 5j3x – hUPL (mutant)
    
  • 1d5f – hUPL catalytic domain
    
  • 1yiu – hUPL WW3 domain - NMR
    
  • 2k4d – hUPL RING domain
    
  • 2ldr – hUPL RING domain - NMR
    
  • 2oo9, 2ooa, 2oob – hUPL UBA domain
    
  • 2do6, 2ekk, 2jnh, 2juj – hUPL UBA domain - NMR
    
  • 3vgo – hUPL N terminal
    
  • 2kr1 – hUPL N terminal - NMR
    
  • 2d9s – mUPL UBA domain – mouse - NMR
    
  • 6bk5 – UPL - Salpingoeca rosetta
    
• Ubiquitin protein ligase Cbl complex
  • 1yvh, 6xar – hUPL TKB domain + APS adaptor protein
    
  • 3bum, 3bun, 3buo, 3buw, 3bux, 3ob1, 3ob2, 3rlf, 3pfv, 2k4d, 4gpl, 5hl0, 7siy – hUPL TKB domain + peptide
    
  • 8gcy, 8qng, 8qnh, 8qni, 8qtj, 8qtk – hUPL TKB domain + inhibitor
    
  • 6o02, 6o03 – hUPL TKB domain + monobody
    
  • 2y1n – hUPL residues 47-435 + ZAP peptide
    
  • 5o76 – hUPL residues 47-435 (mutant) + ZAP peptide
    
  • 4a49 – hUPL RING domain + E2 D2
    
  • 4a4b, 4a4c – hUPL TKB domain (mutant) + ZAP peptide + E2 D2
    
  • 5axi – mUPL-B TKB domain + cblin
    
• Ubiquitin protein ligase cereblon
  • 5v3o – hCRBN + DNA damage-binding protein
    
  • 5hxb – hCRBN + DNA damage-binding protein + eukaryotic peptide chain release factor
    
  • 5fqd – hCRBN + DNA damage-binding protein + casein kinase I + lenalidomide
    
  • 4tz4 – hCRBN + DNA damage-binding protein + lenalidomide
    
  • 6bnb, 6bn7, 6bn8, 6bn9, 6boy – hCRBN + DNA damage-binding protein + bromodomain-containing protein
    
  • 3wx1, 3wx2 – mCRBN thalidomide-binding domain - mouse
    
  • 4tzc, 5yiz, 5yj0, 5yj1 – mCRBN thalidomide-binding domain + thalidomide
    
  • 4tzu – mCRBN thalidomide-binding domain + pomalidomide
    
  • 4ci1 – cCRBN + DNA damage-binding protein + thalidomide - chicken
    
  • 4ci2 – cCRBN + DNA damage-binding protein + lenalidomide
    
  • 4ci3 – cCRBN + DNA damage-binding protein + pomalidomide
    
  • 5ami – MgCRBN 4 – Magnetospirillum griphyswaldense
    
  • 5amh, 5maj, 5amk, 4v2r – MgCer 4 + thalidomide
    
  • 4v32 – MgCRBN 4 (mutant) + thalidomide
    
  • 4v2z, 4v30, 6r0c, 8r0s, 6r0u, 6r0v, 6r1d – MgCRBN 4 + thalidomide derivative
    
  • 4v31 – MgCRBN 4 + deoxyuridine
    
  • 6r11, 6r13, 6r18, 6r19, 6r1a, 6r1c, 6r1k, 6r1w, 6r1x – MgCRBN 4 + effector
    
• Ubiquitin protein ligase CHFR
  • 2xoc, 2xoy, 2xoz – hUPL C terminal + nucleotide
    
  • 2xp0 – hUPL C terminal
    
• Ubiquitin protein ligase CHIP
  • 4kbq – hUPL TPR domain + Hsc70
    
  • 6efk, 6nsv – hUPL TPR domain + Hsc70 peptide
    
  • 8fyu – hUPL TPR domain + Tau peptide
    
  • 7tb1, 8ehz, 8ei0, 8f14, 8f15, 8f16, 8f17 – hUPL TPR domain + peptide
    
• Ubiquitin protein ligase CNOT4
  • 2cpi – mUPL RNA recognition motif - NMR
    
• Ubiquitin protein ligase COP1
  • 5hqg - hUPL WD40 domain
    
  • 5igq – hUPL WD40 domain + Trib1 peptide
    
  • 5igo – AtUPL WD40 domain + Trib1 peptide - Arabidopsis thaliana
    
  • 5kwn, 6qto, 6qtt,6qtv, 6qtx – AtUPL WD40 domain + transcription factor peptide
    
  • 6qtr – AtUPL WD40 domain (mutant) + transcription factor peptide
    
  • 6qto, 6qtw – AtUPL WD40 domain + photoreceptor peptide
    
  • 7vgg – AtUPL WD40 domain + photoreceptor peptide – Cryo EM
    
  • 6qts – AtUPL WD40 domain (mutant) + photoreceptor peptide
    
  • 6qtu – AtUPL WD40 domain + BBX peptide
    
• Ubiquitin protein ligase DOA10 or ring-type E3 ubiquitin transferase DOA10
  • 8pd0, 8pda – yUPL – yeast - Cryo EM
    
  • 2m6m – yUPL RING domain 19-101 - NMR
    
• Ubiquitin protein ligase DTX
  • 6y5n – hUPL 1 RING-DTC domain 388-620
    
  • 6y5p – hUPL 1 RING-DTC domain + NAD
    
  • 3pg6 – hUPL L3 C terminal
    
  • 8r79 – hUPL L3 D2 domain 126-200
    
• Ubiquitin protein ligase E3A or E6AP
  • 6tgk – hUPL C-lobe domain 765-869
    
  • 7qpb – hUPL C-lobe domain + peptide
    
  • 8ept – hUPL AZUL domain 1-87
    
  • 8enp – hUPL AZUL domain - NMR
    
  • 1c4z – hUPL catalytic domain 518-875 + E2
    
• Ubiquitin protein ligase EDD1
  • 2qho – hUPL UBA domain + ubiquitin
    
• Ubiquitin protein ligase FANCL
  • 3zqs – hUPL residues 109-294
    
  • 4ccg – hUPL RING domain + E2 T
    
  • 3k1l – DmUPL - Drosophila melanogaster
    
• Ubiquitin protein ligase HACE1
  • 8hae – hUPL HECT domain residues 1-909 – Cryo EM
    
• Ubiquitin protein ligase HAKAI
  • 3vk6 – mUPL phosphotyrosine-binding domain
    
  • 2mq1 – mUPL phosphotyrosine-binding domain - NMR
    
• Ubiquitin protein ligase HECTD1 Domains: CHP 1268-1340;helical bundle 1879-1966;
  • 3dkm – hUPL CPH domain
    
  • 2dk3 – hUPL CHP domain - NMR
    
  • 2lc3 – hUPL helical bundle domain - NMR
    
• Ubiquitin protein ligase HECW
  • 3l4h – hUPL 1 WW2 and helical box domains
    
  • 2lfe – hUPL 2 N terminal - NMR
    
• Ubiquitin protein ligase HERC
  • 4o2w – hUPL 1 3rd RCC1-like domain
    
  • 4l1m – hUPL 2 1st RCC1-like domain 417-790
    
  • 7rgw – hUPL 2 DOC domain 2759-2914
    
  • 7q41 – hUPL 2 2nd RCC1-like domain 2938-3342 + UPL E3A peptode
    
• Ubiquitin protein ligase HOIL-1
  • 7yuj, 8bvl – hHOIL-1 IBR-RING2 domain 368-510 + Zn
    
  • 2lgy – hHOIL-1 ubiquitin-like domain 51-139 + Zn – NMR
    
  • 4dbg – hHOIL-1 ubiquitin-like domain + HOIL-interacting protein
    
  • 7v8e – hHOIL-1 ubiquitin-like domain + ring-type ubiquitin transferase
    
  • 7yui – hHOIL-1 195-493 + polyubiquitin-C + Zn
    
  • 8eaz – hHOIL-1 232-510 + E2 + ubiquitin + Zn
    
  • 8im5 – mHOIL-1 ZNF domain 192-250 + Zn - NMR
    
  • 3b08, 3b0a – mHOIL-1 ZNF domain 192-250 + polyubiquitin-C + Zn
    
• Ubiquitin protein ligase HRD
  • 6a3z – hUPL 1 zinc finger 279-334 - NMR
    
  • 6f98 – yUPL 1 RING domain 337-412 - NMR
    
  • 5v6p – yUPL 1 1-407 – Cryo EM
    
  • 6vjy, 6vk1 – yUPL 1 + yUPL 3 – Cryo EM
    
  • 6vjz, 6vk0 – yUPL 1 + yUPL 3 + DER1 + USA1 – Cryo EM
    
• Ubiquitin protein ligase HUWE1 Domains: WWE 1611-1700; UBM1 2951-3003; HECT 4005-4374
  • 7jq9, 7mwd, 7mwe, 7mwf - hUPL – Cryo EM
    
  • 6miw - hUPL WWE domain
    
  • 6pfl - hUPL WWE domain + ADPR
    
  • 3g1n, 5lp8 – hUPL HECT domain
    
  • 3h1d – hUPL HECT domain (mutant)
    
  • 2mul, 2ekk – hUPL UBM1 domain - NMR
    
  • 6fyh – hUPL residues 4255-4374 (mutant) + ubiquitin
    
  • 7mop - hUPL + DDIT4 – Cryo EM
    
  • 7bii - NeUPL - Nematocide
    
  • 7nh3 - NeUPL – Cryo EM
    
• Ubiquitin protein ligase IpaH or ring-type E3 ubiquitin transferase
  • 7v8h, 7ya7, 7ya8 – SfUPL 1.4 LRR domain – Shigella flexneri
    
  • 7v8e, 7v8g – SfUPL 1.4 LRR domain + HOIL-1 Ubl domain
    
  • 8gtj – SfUPL 7.8 LRR domain + GSDMB
    
  • 5b0n, 5b0t – SfUPL 9.8 LRR domain
    
  • 6k2d – SfUPL 9.8 LRR domain + GBP1
    
  • 6lol – SfUPL 9.8
    
• Ubiquitin protein ligase ITCHY Domains: C2 1-155; WW3 282-320; WW4 324-363; HECT 524-903
  • 5dws, 5cq2, 4rof – hUPL WW3 domain + TXNIP
    
  • 5dzd – hUPL WW4 domain + TXNIP
    
  • 3tug – hUPL HECT domain
    
  • 5c7m – hUPL HECT domain + ubiquitin
    
  • 2nq3 – hUPL C2 domain
    
  • 5xmc – mUPL
    
  • 2dmv, 2kyk – mUPL WW2 domain - NMR
    
  • 2joc, 1yiu – mUPL WW3 domain - NMR
    
  • 2ysf – mUPL WW4 domain - NMR
    
  • 2jo9 – mUPL WW3 domain + Epstein-Barr virus peptide - NMR
    
• Ubiquitin protein ligase Listerin (Ltn1)
  • 5fg0, 5fg1 – yUPL N-terminal domain
    
• Ubiquitin protein ligase LNX
  • 3b76 – hUPL 3rd PDZ domain
    
  • 5h7r – hUPL residues 11-138
    
  • 5h7s – hUPL residues 11-138 + E2 N + ubiquitin
    
  • 3vqf – mUPL 2rd PDZ domain
    
  • 3vqg – mUPL 2rd PDZ domain + peptide
    
• Ubiquitin protein ligase LUBX
  • 4wz2, 4xi1, 4wz0 – LpUPL (mutant) – Legionella pneumophila
    
  • 4wz3 – LpUPL + E2 D2
    
• Ubiquitin protein ligase MAEA
  • 8pjn – hUPL residues + E2 H + CLTH + ubiquitin – Cryo EM
    
• Ubiquitin protein ligase MDM2 see MDM2
• Ubiquitin protein ligase MEX3C
  • 5www – hUPL KH1 domain 221-306 + RNA
    
  • 5wwx, 5wwz – hUPL KH2 domain 320-396 + RNA
    
  • 5zi6 – hUPL RING domain 605-659
    
• Ubiquitin protein ligase MIB1
  • 4tse, 4xi6 – hUPL MIND BOMB domain
    
  • 4xi7, 4xib – hUPL MIND BOMB domain + peptide
    
• Ubiquitin protein ligase MID
  • 5im8 – hUPL 1 COS domain - NMR
    
  • 7qry – hUPL 1 PSY-SPRY domain
    
  • 7qrz – hUPL 2 PSY-SPRY domain
    
• Ubiquitin protein ligase MMS21
  • 7yqh – yUPL in structural maintainance of chromosomes complex – Cryo EM
    
• Ubiquitin protein ligase MSL-2
  • 4rkg, 4rkh – DmUPL CXC domain + DNA
    
• Ubiquitin protein ligase MYCBP2
  • 5o6c – hUPL residues 4379-4638
    
  • 6t7f – hUPL + ubiquitin + E2 D3
    
  • 3gbw – mUPL 1st PHR domain
    
  • 3hwj – mUPL 2nd PHR domain
    
• Ubiquitin protein ligase MYLIP Domains: FERM 1-344; F3ab 183-283; RING 369-445
  • 6qly – hUPL FERM domain
    
  • 6qlz – hUPL F3ab domain
    
  • 2yhn – hUPL RING domain
    
  • 2yho – hUPL RING domain + E2
    
• Ubiquitin protein ligase NEDD4; Domains – C2 101-252; HECT 519-900; WW3 841-874
  • 3b7y – hUPL C2 domain
    
  • 2xbf – hUPL HECT domain
    
  • 4be8 – hUPL HECT domain (mutant)
    
  • 4n7f – hUPL WW3 domain
    
  • 1wr3, 1wr4, 1wr7 – mUPL WW domain - NMR
    
  • 2n8s – rUPL WW1 domain – rat - NMR
    
  • 2n8u – rUPL WW2 domain - NMR
    
  • 5aht – rUPL WW3 domain - NMR
    
• Ubiquitin protein ligase NEDD4 complex
  • 2kpz, 2kq0, 2laj, 2ltz, 2m3o – hUPL WW3 domain + peptide - NMR
    
  • 4n7h – hUPL WW3 domain + arrestin peptide
    
  • 3m7f – hUPL C2 domain + growth factor receptor bound protein
    
  • 5c91 – hUPL HECT domain + inhibitor
    
  • 2xbb, 5c7j, 5hpl – hUPL HECT domain + ubiquitin
    
  • 4bbn – hUPL HECT domain (mutant) + polyubiquitin
    
  • 1i5h – rUPL WW3 domain + amiloride-sensitive Na channel β subunit
    
  • 2n8t – rUPL WW2 domain + peptide - NMR
    
  • 2ez5 – DmUPL WW3 domain + COMM LPSY peptide - NMR
    
• Ubiquitin protein ligase NEDD4-like; Domains – C2 1-154; WW1 193-226; WW2 365-398; HECT 594-967; WW3 493-539; PY 945-957
  • 2oni – hUPL HECT domain
    
  • 2nsq – hUPL C2 domain
    
  • 7lp5 – hUPL WW3 domain
    
  • 7lp4 – hUPL WW3 domain - NMR
    
  • 2mpt – hUPL WW3 domain + PY domain - NMR
    
  • 7lp3 – hUPL WW1 domain + peptide
    
  • 5hpk – hUPL HECT domain + ubiquitin
    
  • 3jvz, 3jw0 – hUPL HECT domain + ubiquitin + E2 D2
    
  • 2lty, 2lb2 – hUPL WW2 domain + peptide - NMR
    
  • 7lp2 – hUPL WW3 domain + peptide
    
  • 7lp1 – hUPL WW2 domain + peptide
    
  • 2laj – hUPL WW3 domain + peptide - NMR
    
• NEDD4-like Ubiquitin protein ligase WWP Domains: WW1 379-922; WW4 438-480; HECT 537-917
  • 1nd7 – hUPL 1 HECT domain
    
  • 6j1x, 6j1y – hUPL 1 WW1 domain
    
  • 2op7 – hUPL 1 WW4 domain - NMR
    
  • 5hps – hUPL 1 HECT domain + ubiquitin
    
  • 5hpt – hUPL 1 HECT domain + ubiquitin + E2 L3
    
  • 4y07 – hUPL 2 HECT domain
    
  • 8ei5 – hUPL 2 HECT domain + peptide
    
  • 5tj8, 5tjq, 5tj7, 6j1z – hUPL 2 WW2+WW3+linker+HECT domain
    
  • 6rss – hUPL 2 WW4 domain - NMR
    
• Ubiquitin protein ligase Orthrus 2
  • 7duf – AtUPL PHD finger domain 1-63
    
• Ubiquitin protein ligase Parkin See Parkin
• Ubiquitin protein ligase Ppil
  • 7abi, 7dvq, 7qtt – hUPL 2 in spliceosome – Cryo EM
    
• Ubiquitin protein ligase Praja
  • 2l0b – hUPL RING-type zinc finger domain - NMR
    
• Ubiquitin protein ligase pep5
  • 8cuk – yUPL WD40 domain 1-350
    
  • 7zu0 – yUPL in HOPS tethering complex – Cryo EM
    
• Ubiquitin protein ligase PRT6
  • 6lhn, 7xwd, 7xwe, 7xwf, 7xwg, 7y6w, 7y6x, 7y6y, 7y6z, 7y70 – AtUPL UBR box 119-188
    
  • 7wuk, 7wum – riUPL UBR box - rice
    
  • 7wul, 7wun – riUPL UBR box + peptide
    
  • 6lhn – AtUPL
    
• Ubiquitin protein ligase RAD18 Domains: RING 1-99; UBZ 198-227; rad6-binding 340-366
  • 2y43 – hUPL RING domain
    
  • 2mrf, 5vf0 – hUPL UBZ domain - NMR
    
  • 2mre – hUPL UBZ domain + ubiquitin - NMR
    
  • 2ybf – hUPL rad6-binding domain + E2 B
    
• Ubiquitin protein ligase RavN
  • 5miy – UPL - Legionella pneumophila
    
• Ubiquitin protein ligase RBBP6
  • 3ztg – hUPL RING domain - NMR
    
• Ubiquitin protein ligase RBX
  • 2lgv – hUPL 1 (mutant) - NMR
    
  • 3rtr, 4f52 – hUPL 1 + cullin-1
    
  • 4a0k, 4a0c – hUPL 1 + cullin-4B + cullin-associated NEDD8-dissociated protein
    
  • 4p5o – hUPL 1 + cullin-1 + Ubc12 + DCN1-like protein
    
  • 7z8r – hUPL 1 + cullin-1 + CAND1 – Cryo EM
    
  • 8or2 – hUPL 1 + cullin-1 + CAND1 + DCN1-like protein – Cryo EM
    
  • 8cdj, 8cdk – hUPL 1 + cullin-1 + CAND1 + SKP1 + SKP2 – Cryo EM
    
  • 8or3 – hUPL 1 + cullin-1 + CAND1 + SKP1 + SKP2 + DCNL1 – Cryo EM
    
  • 8or0, 8or4 – hUPL 1 + cullin-1 + CAND1 + SKP1 + SKP2 + CKS-1 + CDK 2 – Cryo EM
    
  • 7b5n – hUPL 1 + hPolyUBB-C + cullin-1 + Nedd8 + ARITH1 + Ube2L3 – Cryo EM
    
  • 6ttu – hUPL 1 + cullin-1 + F-Box/WD repeat-containing protein + S-phase kinase-associated protein + Nedd8 + E2 D2 + polyubiquitin-C + peptide – Cryo EM
    
  • 5n4w – hUPL 1 + cullin-2 + elongin B + elongin C + VHL
    
  • 8ij1, 8je1 – hUPL 1 + cullin-2 + elongin B + elongin C + FEM-1 – Cryo EM
    
  • 8pql – hUPL 1 + cullin-2 + Nedd8 + E2 R2 + elongin B + elongin C + FEM-1 + Ub + SIL1 – Cryo EM
    
  • 8p7r – hUPL 1 + cullin-2 + elongin B + elongin C + FEM-1 + Ub + SIL1 – Cryo EM
    
  • 8jas, 8jav – hUPL 1 + cullin-2 + elongin B + elongin C + Degron – Cryo EM
    
  • 8gq6, 8h33, 8h34, 8h35, 8h3r – hUPL 1 + cullin-3 + KBTBD2 – Cryo EM
    
  • 8h36, 8h37 – hUPL 1 + cullin-3 + KBTBD2 + p85A – Cryo EM
    
  • 8khp – hUPL 1 + cullin-3 + KLHL22 – Cryo EM
    
  • 8h3q – hUPL 1 + cullin-3 + CAND1 – Cryo EM
    
  • 8b3i – hUPL 1 + cullin-4a + E2 D2 + Nedd8 + Ub + Ercc-8 + DNA damage-binding protein – Cryo EM
    
  • 7okq – hUPL 1 + DDB1 + cullin-4a + DCAF1
    
  • 4a0l – hUPL 1 + cullin-4b + DNA damage-binding protein + DNA
    
  • 7z8b – hUPL 1 + cullin-7 + F-Box/WD repeat-containing protein + S-phase kinase-associated protein – Cryo EM
    
  • 8h38, 8h3a, 8h3f – hUPL 1 in signalosome complex – Cryo EM
    
  • 7opc, 7opd – hUPL 1 in transcription-DNA repair coupling complex – Cryo EM
    
• Ubiquitin protein ligase RFWD
  • 5hqg – hUPL 2
    
  • 6cvz – hUPL 3 WD40-repeat domain
    
• Ubiquitin protein ligase RGLG
  • 6k87, 6k88, 6k89, 6k8a, 6k8b – AtUPL 1 VWA domain
    
  • 6k82, 6k83, 6k85, 6k86 – AtUPL 1 VWA domain (mutant)
    
  • 8hmg, 8hmh – AtUPL 2 VWA domain
    
• Ubiquitin protein ligase RING2
  • 3h8h – hUPL C terminal
    
  • 3gs2 – hUPL C terminal + chromobox protein homolog
    
  • 3ixs – hUPL C terminal (mutant) + RING1 and YY1-binding protein
    
  • 3rpg, 4s3o – hUPL + polycomb complex protein BMI-1 + E2 D3
    
  • 4r8p – hUPL + polycomb complex protein BMI-1 + histones + DNA
    
  • 6wi8 – hUPL + polycomb complex protein BMI-1
    
  • 7nd1 – hUPL + polycomb complex protein BMI-1 + inhibitor - NMR
    
  • 2ckl – mUPL RING domain + polycomb group ring finger protein 4
    
  • 2h0d – mUPL RING domain + B lymphoma MO-MLV insertion region
    
• Ubiquitin protein ligase RLIM/Rnf12
  • 6w7z – hUPL RING domain + E2 D2
    
  • 6w9a – hUPL RING domain + E2 E2
    
  • 6w9d – hUPL RING domain + ubiquitin + E2 D2
    
• Ubiquitin protein ligase RMD5
  • 7ns4 – yUPL + FYV10 – Cryo EM
    
  • 8pmq – yUPL + FYV10 + E2 24kDa + Ub – Cryo EM
    
• Ubiquitin protein ligase RNF or ring finger protein Domains: PUB 1-184; RING 216-290; Pry-Spry 249-432;catalytic 853-1072;
  • 4ppe, 3ng2 – hUPL 4 RING domain
    
  • 2pie – hUPL 8 FHA domain
    
  • 2csw – hUPL 8 FHA domain - NMR
    
  • 4ayc, 4gb0 – hUPL 8 RING domain
    
  • 5zc4 – hUPL 13 RING domain
    
  • 4juy, 4oyj, 4p09 – hUPL 31 PUB domain
    
  • 4ljq, 6gzy – hUPL 31 catalytic domain
    
  • 2ma6 – hUPL 123 RING domain - NMR
    
  • 5dka – hUPL 125 (mutant)
    
  • 2n9o – hUPL 126 N-terminal - NMR
    
  • 3icu – hUPL 128 protease-associated domain
    
  • 6l99 – hUPL 144A N-terminal - NMR
    
  • 3v3l – hUPL 146 zinc finger
    
  • 5d0i – hUPL 165 residues 255-348
    
  • 7r70 – hUPL 165 residues 255-348/Ub
    
  • 3l11, 4gb0 – hUPL 168 RING domain
    
  • 5zi6 – hUPL 194 residues 605-659
    
• Ubiquitin protein ligase RNF complex
  • 4ap4, 5ait, 5aiu – hUPL 4 RING domain + E2 N + ubiquitin
    
  • 4orh – hUPL 8 residues 345-485 + E2 N
    
  • 4whv – hUPL 8 residues 345-485 + ubiquitin + E2 N
    
  • 5d1k, 5d1l, 5d1m – hUPL 25 residues 126-258 + E2 D2
    
  • 6gzy, 6kc5, 6kc6 – hUPL 31 catalytic domain + inhibitor
    
  • 6sc6 – hUPL 31 catalytic domain + antibody
    
  • 6sc5, 6sc7, 6sc8, 6sc9 – hUPL 31 catalytic domain + antibody + inhibitor
    
  • 4ljo – hUPL 31 catalytic domain + ubiquitin
    
  • 4ljp – hUPL 31 catalytic domain (mutant) + ubiquitin
    
  • 5edv – hUPL 31 catalytic domain + ubiquitin + E2 D2
    
  • 7v8f – hUPL 31 catalytic domain + E2 L3
    
  • 4owf – hUPL 31 catalytic domain + nf-κ-B modulator
    
  • 4oyk, 4p0b – hUPL 31 PUB domain + otulin
    
  • 7uy2, 7uyk – hUPL 31 PUB domain + peptide
    
  • 4p0a – hUPL 31 PUB domain + p97 peptide
    
  • 5ljn – hUPL 31 PUB domain + SPATA2 peptide
    
  • 5x0w – hUPL 31 residues 480-639 + Sharpin
    
  • 5y3t – hUPL 31 residues 474-630 + Sharpin + HOIL-7
    
  • 5zbu – hUPL 31 RING domain (mutant) + ubiquitin-C + E2 D2
    
  • 7v8g – hUPL 31 catalytic domain + ubiquitin transferase
    
  • 7ojx – hUPL 38 residues 439-515 + polyubiquitin-B + E2 K
    
  • 4v3k, 4v3l – hUPL 38 residues 439-515 + polyubiquitin-C + E2 D2
    
  • 4kng – hUPL 43 PA domain + LGR5 + RSPO1
    
  • 8gbq, 8gcb – hUPL 125 residues 32-127 + E2 D2
    
  • 2n9p – hUPL 126 N-terminal + BAG6 ubiquitin-like domain - NMR
    
  • 7jl1, 7jl3, 8g7t, 8g7u, 8g7v – hUPL 135 Pry-Spry domain + RIG-I + RNA - Cry EM
    
  • 5d0k, 5d0m, 5ulh, 5ulk, 7r71 – hUPL 165 residues 255-348 + ubiquitin + E2 D2
    
  • 5xis, 5xit, 5xiu, 5ydk – hUPL 168 residues 110-188 + diubiquitin
    
  • 8smw, 8smx, 8smy, 8smz, 8sn0, 8sn1, 8sn2, 8sn3, [[[8sn4|8sn4]], [8sn5]], 8sn6, 8sn7, 8sn8, 8sn9, 8sna, 8txw, 8u13, 8u14, 8upf – hUPL 168 in nucleosome – Cryo EM
    
  • 8uqa – hUPL 168/histone H2A/histone H2B – Cryo EM
    
  • 8uq9, 8uqb, 8uqc, 8uqd, 8uqe – hUPL 168/E2 D3/histone H2A/histone H2B – Cryo EM
    
  • 5vey – hUPL 169 residues 653-708 + polyubiquitin + histone 2B - NMR
    
  • 7m4n, 7m4o – hUPL 216 residues 649-784 (mutant) + ubiquitin
    
  • 8eb0 – hUPL 216 residues 510-784 (mutant) + E2 L3 + ubiquitin
    
  • 7m4m – hUPL 216 + Ub
    
  • 2rsf – mUPL 146 WWE domain + ATP
    
  • 4qpl – mUPL 146 RING+WWE domains + E2
    
  • 6tax, 7oim – mUPL 213 + ATP - Cryo EM
    
  • 6tay – mUPL 213 (mutant) + ATP - Cryo EM
    
  • 7oik – mUPL 213 + E2 L3 + ATP - Cryo EM
    
• Ubiquitin protein ligase RSP
  • 4lcd – hUPL 3 HECT + WW3 domains (mutant) + SNA3 peptide + ubiquitin
    
  • 3olm – hUPL 5 HECT + WW3 domains + ubiquitin
    
• Ubiquitin protein ligase SHPRH
  • 2m85 – hUPL PHD domain - NMR
    
  • 4qn1 – hUPL residues 1000-1418
    
• Ubiquitin protein ligase SH3RF
  • 7nzc – hUPL SH3-1 domain domain
    
  • 7nzd – hUPL SH3-4 domain domain
    
• Ubiquitin protein ligase SIAH Domains: SINA 93-282
  • 4c9z, 4ca1 – hUPL 1 SINA domain
    
  • 2a25 – hUPL 1 SINA domain + calcyclin-binding protein peptide
    
  • 4x3g, 5wzz, 8heo – hUPL 1 SINA domain + peptide
    
  • 4i7b, 4i7d – hUPL 1 C terminal + phyllopod peptide
    
  • 4i7c – hUPL 1 C terminal (mutant) + phyllopod pept
  • 5h9m – hUPL 2 SINA domain
    
  • 2an6 – mUPL 1 SINA domain + phyllopod peptide
    
• Ubiquitin protein ligase SLRP
  • 4puf – SeUPL + thioredoxin - Salmonella enterica
    
• Ubiquitin protein ligase SMURF
  • 2laz, 2lb0, 2lb1, 2ltx – hUPL 1 WW + peptide - NMR
    
  • 3pyc – hUPL 1 C2 domain
    
  • 2jqz – hUPL 2 C2 domain - NMR
    
  • 2kxq – hUPL 2 WW2 and WW3 + peptide
    
  • 6fx4 – hUPL 2 + ubiquitin
    
  • 7m3q – hUPL 2 HECT domain + ubiquitin
    
• Ubiquitin protein ligase SopA
  • 2qyu, 2qza – SeUPL residues 165-782
    
  • 3sy2 – SeUPL residues 165-782 + ubiquitin + E2 L3
    
  • 5jw7 – SeUPL residues 163-425 + TRIM56
    
  • 8st8, 8st9 – EcUPL residues 606-782 + ubiquitin
    
• Ubiquitin protein ligase SSPH1
  • 4nkh – SeUPL 21 LRR domain
    
  • 4nkg – SeUPL 21 LRR domain + Ser/Thr protein kinase N1 peptide
    
• Ubiquitin protein ligase TIR1
  • 2p1q – AtUPL + auxin response protein + SKP1-like protein
    
  • 2p1q – AtUPL + auxin response protein + SKP1-like protein + herbicide
    
• Ubiquitin protein ligase TRAF or ring-type E3 ubiquitin transferase TRAF
  • 6myd – zUPL 6 370-525 + STING CTT - zebrafish
    
  • 8ims – hUPL 7 coiled-coil domain 194-303
    
• Ubiquitin protein ligase TRIM Domains RING 1-123; B2-box 117-161; coiled-coil 203-393; PRY-SPRY 249-442; NHL 590-868; PHD-bromo 882-1087
  • 8a38 – hUPL 2 RING domain
    
  • 7b2r, 7b96, 7qrv – hUPL 2 NHL domain
    
  • 6uma, 6umb – hUPL 7 B30.2 domain
    
  • 7b2s – hUPL 9 PRY-SPRY domain
    
  • 7qs1 – hUPL 11 PRY-SPRY domain
    
  • 6jbm – hUPL 14 PRY-SPRY domain
    
  • 7qs3 – hUPL 16 PRY-SPRY domain
    
  • 5olm – hUPL 21 residues 1-129
    
  • 5jpx – hUPL 21 B2-Box domain - NMR
    
  • 5vzv – hUPL 23 RING domain
    
  • 7b9x – hUPL 24 901-1006 - NMR
    
  • 6flm – hUPL 25 PRY-SPRY domain
    
  • 6fln – hUPL 25 PRY-SPRY + coiled-coil domains
    
  • 4ltb – hUPL 25 coiled-coil
    
  • 4cfg – hUPL 25 coiled-coil (mutant)
    
  • 6i9h – hUPL 28 RING domain - NMR
    
  • 2yjs, 2ysl – hUPL 31 RING domain - NMR
    
  • 5fey – hUPL 32 RING domain
    
  • 2ct2 – hUPL 32 RING domain - NMR
    
  • 3u5m – hUPL 33 PHD+Bromo domains
    
  • 3ddt – hUPL 37 B2-box
    
  • 8pd4, 8pd6 – hUPL 58 PRY-SPRY domain
    
  • 4m3l – hUPL 63 coiled-coil domain
    
  • 4nqj – hUPL 69 coiled-coil domain
    
  • 6yxe – hUPL 69 RING domain
    
  • 7qrx – hUPL 71 NHL domain
    
  • 3kb5 – hUPL 72 PRY-SPRY domain
    
  • 7xyy – hUPL 72 2-477
    
  • 2v0k – mUPL 21 PRY-SPRY domain
    
  • 4b8e – mUPL 25 PRY-SPRY domain
    
  • 6o5k – mUPL 28 B2-box domain
    
  • 8fvf – mUPL 56 coiled-coil domain
    
  • 7xyz, 7xz1, 7xz2 – mUPL 72 7-470 (mutant)
    
  • 6fpt – zUPL 71
    
• Ubiquitin protein ligase TRIM complexes
  • 7zj3 – hUPL 2 RING domain + E2 D1 + polyubiquitin-C
    
  • 8ams – hUPL 2 RING domain + E2 D3 + polyubiquitin-C
    
  • 7ow2, 7w0q, 7w0s, 8a5l, 8a5m, 8a8x – hUPL 7 PRY-SPRY domain + peptide
    
  • 8r5c – hUPL 7 PRY-SPRY domain + indole derivative
    
  • 7ovx, 7w0t, 7x6y, 7x6z, 7x70, 7y3a, 7y3b, 7y3c – hUPL 7 338-531+ peptide
    
  • 6fga – hUPL 21 RING domain + E2 E1
    
  • 8a58 – hUPL 21 RING domain + E2 W
    
  • 6s53 – hUPL 21 RING domain + E2 N + polyubiquitin-C
    
  • 7bbd – hUPL 21 RING domain + E2 N + E2 2 + polyubiquitin-C
    
  • 6s53 – hUPL 21 RING domain + ubiquitin + E2 N
    
  • 5vzw – hUPL 23 RING domain + ubiquitin + E2 D2
    
  • 5eya – hUPL 25 RING domain + ubiquitin + E2 N
    
  • 5fer – hUPL 25 RING domain + ribosomal protein S2 + E2 D1
    
  • 5nt1, 5nt2 – hUPL 25 coiled-coil + nonstructural protein
    
  • 3u5n, 3u5o, 3u5p, 5mr8, 7zdd – hUPL 33 PHD+Bromo domain + H3-histone peptide
    
  • 8bd8, 8bd9, 8bdy – hUPL 33 PHD+Bromo domain + inhibitor
    
  • 7qrx – hUPL 71 NHL domain
    
  • 5w9a – UPL 5 88-296 domain (mutant) + MAP 1A/1B - monkey
    
  • 3zo0 – mUPL 21 PRY-SPRY domain + IG γ-2A
    
  • 6fq3, 6fql – zUPL 71 + RNA
    
• Ubiquitin protein ligase TRIP
  • 9bks – hUPL 12 WWW domain 761-839 + ADP
    
• Ubiquitin protein ligase UBR
  • 8d4x– hUPL 1 – Cryo EM
    
  • 3ny1, 3ny2 – hUPL 1 UBR-box 98-168
    
  • 3ny3 – hUPL 1 UBR-box + N-degron
    
  • 5tdc – hUPL 1 UBR-box + peptide
    
  • 7mex, 7mey – hUPL 1 UBR-box + Ub + degron + E2 – Cryo EM
    
  • 5um3 – hUPL 2 UBR-box (mutant)
    
  • 5tda – hUPL 2 UBR-box + N-degron
    
  • 5tdd, 5tdb – hUPL 2 UBR-box + peptide
    
  • 8j9q, 8j9r – hUPL 4 UBR-box
    
  • 8bja, 8e0q – hUPL 5 – Cryo EM
    
  • 8c06 – hUPL 5 (mutant) – Cryo EM
    
  • 8c07 – hUPL 5 + polyubiquitin-B – Cryo EM
    
  • 3pt3 – hUPL 5 C terminal
    
  • 5vmd – hUPL 6 UBR-box
    
  • 3ntw – rUPL 5 MLLE domain + peptide
    
  • 3nis, 3nit, 6kgi – yUPL 1 UBR-box
    
  • 3nih, 3nii, 3nij, 3nik, 3nil, 3nim, 3nin – yUPL 1 UBR-box + peptide
    
• Ubiquitin protein ligase UHRF (Np95) Domains TUDOR 125-285; TTD 146-313; PHD finger 314-367; SRA 414-617; polybasic 638-678' RING 672-793
  • 3sox, 3zvz – hUPL 1 PHD finger
    
  • 2lgl – hUPL 1 PHD finger - NMR
    
  • 3db4, 4qqd, 5yya – hUPL 1 TUDOR domain
    
  • 3fl2 – hUPL 1 RING domain
    
  • 3bi7, 2pb7, 3dwh – hUPL 1 SRA domain
    
  • 6w92 – hUPL 1 TTD domain
    
  • 6ved – hUPL 1 TTD domain - NMR
    
  • 3oln – hUPL 2 SRA domain
    
  • 2e6s – hUPL 2 PHD finger - NMR
    
  • 4tvr – hUPL 2 TUDOR + PHD domains
    
  • 2zkg – mUPL 1 SRA domain
    
  • 6vee – mUPL 1 TTD domain - NMR
    
  • 6vfo – mUPL 1 PHD finger - NMR
    
• Ubiquitin protein ligase UHRF complex
  • 3clz, 2zkd, 2zke, 2zkf, 6vcs – hUPL 1 SRA domain + DNA
    
  • 3sou, 3sow, 3shb, 2lgg, 3t6r, 3ask, 3asl, 4gy5, 3zvy – hUPL 1 PHD finger + histone H3 peptide
    
  • 2lgk – hUPL 1 PHD finger + histone H3 peptide - NMR
    
  • 6iiw – hUPL 1 PHD finger + PAF1
    
  • 6b9m – hUPL 1 TUDOR domain + polybasic
    
  • 3db3 – hUPL 1 TUDOR domain + histone H3 peptide
    
  • 2l3r – hUPL 1 TUDOR domain + histone H3 peptide - NMR
    
  • 5iay – hUPL 1 tandem TUDOR domains + spacer peptide - NMR
    
  • 5xpi, 4qqd – hUPL 1 TUDOR domain + inhibitor
    
  • 6vyj, 7fb7 – hUPL 1 TTD domain + inhibitor
    
  • 5yy9 – hUPL 1 TTD domain + peptide
    
  • 6vcs – hUPL 1 SRA domain + DNA
    
  • 4pw5, 4pw6, 4pw7 – hUPL 2 SRA domain + DNA
    
  • 2zo0, 2zo1, 2zo2, 3f8i, 3f8j, 3fde, 6m2v – mUPL 1 SRA domain + DNA
    
• Ubiquitin protein ligase XIAP or baculoviral IAP repeat containing protein 4 Domains: BIR1 10-99; BIR2 152-236; BIR3 249-354; UBA 357-449; RING 429-497
  • 4oxc – hXIAP BIR1 domain
    
  • 6qci – hXIAP BIR1 domain (mutant)
    
  • 4j3y – hXIAP BIR2 domain (mutant)
    
  • 1f9x – hXIAP BIR3 domain – NMR
    >
  • 4ic2, 8w5a – hXIAP RING domain
    
  • 4ic3 – hXIAP RING domain (mutant)
    
  • 2kna – hXIAP UBA domain - NMR
    
• Ubiquitin protein ligase XIAP complex
  • 4mtz, 6gjw – hXIAP BIR1 domain + inhibitor
    
  • 6gjw – hXIAP BIR1 domain + naphthalene derivative
    
  • 2pop – hXIAP BIR1 domain + TAB1
    
  • 3uw5 - hXIAP residues 63-179 (mutant) + peptide
    
  • 4j44, 4j45, 4j46, 4j47, 4j48 - hXIAP BIR2 domain (mutant) + peptide
    
  • 4kju, 4kjv, 4wvs, 4wvt, 4wvu, 4kjv - hXIAP BIR2 domain (mutant) + inhibitor
    
  • 3hl5, 4hy0, 4kmp, 4wvs, 4wvt, 4wvu, 5c0k, 5c0l, 5c3h, 5c3k, 5c7a, 5c7b, 5c7c, 5c7d, 5c83, 5c84, 5oqm, 5oqw, 6h6q, 6h6r – hXIAP BIR3 domain + inhibitor
    
  • 5m6e, 5m6f, 5m6h, 5m6l, 5m6m, 5m6n, 6ey2 - hXIAP BIR3 domain (mutant) + inhibitor
    
  • 2jk7, 2vsl, 3clx, 3cm2, 3cm7, 3eyl, 3g76, 4ec4 – hXIAP BIR3 domain + Smac mimetic
    
  • 8gh7 - hXIAP BIR3 domain + peptide inhibitor
    
  • 3uw4 - hXIAP BIR3 domain (mutant) + peptide
    
  • 5o6t – hXIAP RING domain + diubiquitin
    
  • 8w59 – hXIAP RING domain + AsO3
    
• Ubiquitin protein ligase ZNRF
  • 5ywr – hUPL 1 RING domain + E2 N
    
  • 4ufs – hUPL 3 ectodomain + R-spondin + LGR5
    
  • 8g4y – hUPL 3 ectodomain + peptide
    
  • 4cdj – mUPL 3 ectodomain
    
  • 4c99, 4c9a, 4c9e, 4c9r, 4c9u, 4cdk – mUPL 3 ectodomain + R-spondin
    
  • 4c8t, 4c8u – fUPL 3 ectodomain – frog
    
  • 4c84, 4c85, 4c86, 4c8a, 4c8c, 4c8f – zUPL 3 ectodomain – zebra fish
    
  • 4c8p – zUPL 3 ectodomain (mutant)
    
• Ubiquitin protein ligase ZFP91
  • 2m9a – hUPL residues 370-456 - NMR
    

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Jaime Prilusky