Pyrin domain: Difference between revisions
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Michal Harel (talk | contribs) New page: left|200px|thumb|Crystal Structure of Pyrin domain, [[2km6]] {{STRUCTURE_2km6| PDB=2km6 | SIZE=300| SCENE= |right|CAPTION=Pyrin domain in human NLRP7, 2km6 }} '''... |
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<StructureSection load='' size='450' side='right' caption='NMR structure of pyrin domain in human NLRP7, [[2km6]]' scene='Pyrin_domain/Pyrin_domain/1 ' pspeed='8'> | |||
'''Pyrin domain''' (PYD) is a protein domain known as death fold. This domain allows the protein to interact with other pyrin domains. It is also known as PYD or PAAD/DAPIN or marenostrin domain. Proteins containing pyrin domain are involved in inflammation and apoptosis. The NALP proteins contain domains NACHT, LRR and PYD and are part of the inflammasome. | == Function == | ||
'''Pyrin domain''' (PYD) is a protein domain known as death fold. This domain allows the protein to interact with other pyrin domains. It is also known as PYD or PAAD/DAPIN or marenostrin domain. Proteins containing pyrin domain are involved in inflammation and apoptosis. The NALP proteins contain domains NACHT, LRR and PYD and are part of the inflammasome. A 781-amino acid protein named pyrin contains a PYD domain in its N-terminal<ref>PMID:11514682</ref>. | |||
== Disease == | |||
Mutations in the protein are the cause of Familial Mediterranean fever<ref>PMID:17431422</ref>. | |||
</StructureSection> | |||
== 3D Structures of Pyrin domain == | == 3D Structures of Pyrin domain == | ||
[[Pyrin domain 3D structures]] | |||
== References == | |||
<references/> | |||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Latest revision as of 08:57, 20 August 2026
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