Pyrin domain: Difference between revisions

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[[Image:2km6.png|left|200px|thumb|Crystal Structure of Pyrin domain, [[2km6]]]]
<StructureSection load='' size='450' side='right' caption='NMR structure of pyrin domain in human NLRP7, [[2km6]]' scene='Pyrin_domain/Pyrin_domain/1 ' pspeed='8'>
{{STRUCTURE_2km6|  PDB=2km6  | SIZE=300| SCENE=Pyrin_domain/Pyrin_domain/1 |right|CAPTION=NMR structure of pyrin domain in human NLRP7, [[2km6]] }}


'''Pyrin domain''' (PYD) is a protein domain known as death fold.  This domain allows the protein to interact with other pyrin domains.  It is also known as PYD or PAAD/DAPIN or marenostrin domain.  Proteins containing pyrin domain are involved in inflammation and apoptosis.  The NALP proteins contain domains NACHT, LRR and PYD and are part of the inflammasome.
== Function ==
'''Pyrin domain''' (PYD) is a protein domain known as death fold.  This domain allows the protein to interact with other pyrin domains.  It is also known as PYD or PAAD/DAPIN or marenostrin domain.  Proteins containing pyrin domain are involved in inflammation and apoptosis.  The NALP proteins contain domains NACHT, LRR and PYD and are part of the inflammasome. A 781-amino acid protein named pyrin contains a PYD domain in its N-terminal<ref>PMID:11514682</ref>. 


{{TOC limit|limit=2}}
== Disease ==
Mutations in the protein are the cause of Familial Mediterranean fever<ref>PMID:17431422</ref>.


</StructureSection>
== 3D Structures of Pyrin domain ==
== 3D Structures of Pyrin domain ==


[[Pyrin domain 3D structures]]


 
== References ==
 
<references/>




[[Category:Topic Page]]
[[Category:Topic Page]]
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