Pyrin domain: Difference between revisions

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~~[[Image:2km6.png|left|200px|thumb|Crystal Structure of Pyrin domain, [[2km6]]]]~~

~~{{STRUCTURE_2km6| PDB~~=~~2km6 | SIZE~~=~~300| SCENE~~=~~Pyrin_domain/Pyrin_domain/1 |~~right~~|CAPTION~~=NMR structure of pyrin domain in human NLRP7, [[2km6]] }}

'''Pyrin domain''' (PYD) is a protein domain known as death fold. This domain allows the protein to interact with other pyrin domains. It is also known as PYD or PAAD/DAPIN or marenostrin domain. Proteins containing pyrin domain are involved in inflammation and apoptosis. The NALP proteins contain domains NACHT, LRR and PYD and are part of the inflammasome.

== Function ==

'''Pyrin domain''' (PYD) is a protein domain known as death fold. This domain allows the protein to interact with other pyrin domains. It is also known as PYD or PAAD/DAPIN or marenostrin domain. Proteins containing pyrin domain are involved in inflammation and apoptosis. The NALP proteins contain domains NACHT, LRR and PYD and are part of the inflammasome. A 781-amino acid protein named pyrin contains a PYD domain in its N-terminal<ref>PMID:11514682</ref>.

~~{{TOC limit|limit~~=~~2}}~~

== Disease ==

Mutations in the protein are the cause of Familial Mediterranean fever<ref>PMID:17431422</ref>.

</StructureSection>

== 3D Structures of Pyrin domain ==

[[~~2km6~~]] ~~– hPYD in NLRP7 – human – NMR ~~

[[Pyrin domain 3D structures]]

~~[[2wl1]] – hPYD PRYSPRY residues 586-776 ~~

~~[[2do9]] – mPYD in NALP10 – mouse – NMR ~~

~~[[2yu0]] – mPYD in interferon-activable protein 205 - NMR ~~

~~[[1pn5]] – hPYD in NALP1 - NMR ~~

~~[[1ucp]] - hPYD in apoptosis-associated speck-like protein – NMR ~~

~~[[2hm2]] – hPYD in apoptosis-associated speck-like protein2 – NMR ~~

~~[[2dbg]] – hPYD in myeloid cell nuclear differentiation antigen - NMR ~~

== References ==

[[Category:Topic Page]]

Pyrin domain: Difference between revisions

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@@ Line 1: / Line 1: @@
-[[Image:2km6.png|left|200px|thumb|Crystal Structure of Pyrin domain, [[2km6]]]]
+<StructureSection load='' size='450' side='right' caption='NMR structure of pyrin domain in human NLRP7, [[2km6]]' scene='Pyrin_domain/Pyrin_domain/1 ' pspeed='8'>
-{{STRUCTURE_2km6|  PDB=2km6  | SIZE=300| SCENE=Pyrin_domain/Pyrin_domain/1 |right|CAPTION=NMR structure of pyrin domain in human NLRP7, [[2km6]] }}
-'''Pyrin domain''' (PYD) is a protein domain known as death fold.  This domain allows the protein to interact with other pyrin domains.  It is also known as PYD or PAAD/DAPIN or marenostrin domain.  Proteins containing pyrin domain are involved in inflammation and apoptosis.  The NALP proteins contain domains NACHT, LRR and PYD and are part of the inflammasome.
+== Function ==
+'''Pyrin domain''' (PYD) is a protein domain known as death fold.  This domain allows the protein to interact with other pyrin domains.  It is also known as PYD or PAAD/DAPIN or marenostrin domain.  Proteins containing pyrin domain are involved in inflammation and apoptosis.  The NALP proteins contain domains NACHT, LRR and PYD and are part of the inflammasome. A 781-amino acid protein named pyrin contains a PYD domain in its N-terminal<ref>PMID:11514682</ref>.
-{{TOC limit|limit=2}}
+== Disease ==
+Mutations in the protein are the cause of Familial Mediterranean fever<ref>PMID:17431422</ref>.
+</StructureSection>
 == 3D Structures of Pyrin domain ==
-[[2km6]] – hPYD in NLRP7 – human – NMR<BR />
+[[Pyrin domain 3D structures]]
-[[2wl1]] – hPYD PRYSPRY residues 586-776<br />
-[[2do9]] – mPYD in NALP10 – mouse – NMR<BR />
-[[2yu0]] – mPYD in interferon-activable protein 205 - NMR<BR />
-[[1pn5]] – hPYD in NALP1 - NMR<BR />
-[[1ucp]] - hPYD in apoptosis-associated speck-like protein – NMR<BR />
-[[2hm2]] – hPYD in apoptosis-associated speck-like protein2 – NMR<BR />
-[[2dbg]] – hPYD in myeloid cell nuclear differentiation antigen - NMR<BR />
+== References ==
+<references/>
 [[Category:Topic Page]]