Concanavalin: Difference between revisions

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[[Image:1nxd.png|left|200px|thumb|Crystal Structure of Concanavalin A, [[1nxd]]]]
<StructureSection load='1qdc' size='350' side='right' caption='Concanavalin A complex with trisacchride, Mn+2 (small purple), Cl- (large green) and Ca+2 (small green) ions (large purple) (PDB entry [[1qdc]])' scene='41/415806/Cv/1'>
{{STRUCTURE_1nxd|  PDB=1nxd  | SIZE=300| SCENE=Concanavalin_A/Concanavalin_a/1 |right|CAPTION=Concanavalin A, [[1nxd]] }}
__TOC__
== Function ==


'''Concanavalin A''' (ConA) is a carbohydrate-binding protein from jack-bean ( Canavalia ensiformis).  It binds to certain sugars and to metal.  It is used to characterize glycoproteins on cell surfaces.
'''Concanavalin A''' (ConA) is a carbohydrate-binding protein from jack-bean (''Canavalia ensiformis'').  It binds to certain sugars and to metal.  It is used to characterize glycoproteins on cell surfaces.<ref>PMID:9546043</ref>. 
*'''Concanavalin B''' (ConB) is related to chitinase with 40% sequence identity.<ref>PMID:7490746</ref>. 
*'''Concanavalin BR''' (ConBR) is ConA from Brazilian jack bean.
*'''Concanavalin V''' (ConV) is a D-mannose/D-glucose-binding lectin.


{{TOC limit|limit=2}}
== Relevance ==


ConA has therapeutic effect on liver cancer.


== Structural highlights ==


ConA is the <scene name='41/415806/Cv/2'>homotetramer</scene> with D2 symmetry. ConA contains a <scene name='41/415806/Cv/7'>metal - Mn+2 and Ca+2 - binding site</scene> as well as a <scene name='41/415806/Cv/8'>sugar binding site</scene>.


== 3D Structures of Concanavalin A ==
== 3D Structures of Concanavalin ==
 
[[Concanavalin 3D structures]]
[[2uu8]], [[1nxd]], [[1gkb]], [[3enr]], [[1qny]], [[1vln]], [[1jbc]], [[1cnv]], [[2cna]], [[3cna]] – CeConA – Canavalia ensiformis<br />
[[2yz4]], [[1xqn]], [[1c57]] – CeConA – neutron<br />
[[2ctv]] – CeConA – Laue<br />
[[1cn1]], [[1apn]], [[1dq0]], [[1dq2]] – CeConA demetallized<br />
[[2g4i]], [[2a7a]] – ConA – Canavalia virosa<br />
[[1wuv]] – CgConA – Canavalia gladiata<br />
[[3ju9]], [[1azd]] – ConBR – Brazilian jack-bean
 
===Concanavalin binary complex===
 
[[1dq1]], [[1dq5]], [[1dq6]], [[1qgl]], [[1nls]], [[1scr]], [[1scs]] – CeConA + ion<br />
[[1enq]], [[1enr]], [[1ens]], [[1con]], [[1dq4]], [[2enr]], [[1ces]] - CeConA demetallized + ion<br />
[[3d4k]] – CeConA + sugar analog<br />
[[1hqw]], [[1jyc]], [[1jyi]], [[1jui]], [[1joj]], [[1jw6]] – CeConA + polypeptide<br />
[[1jn2]] – CeConA + porphyrin derivative<br />
[[1cjp]], [[1ona]], [[1gic]], [[1val]], [[1vam]], [[5cna]] – CeConA + pyranoside derivative<br />
[[1i3h]], [[1qdc]], [[1qdo]], [[1bxh]], [[1tei]], [[1cvn]] – CeConA + glucoside<br />
[[2p37]] – ConA + glucoside – Canavalia maritima<br />
[[2ef6]], [[2d7f]] - CgConA + glucoside
 
 


</StructureSection>


== References ==
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]
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