Concanavalin: Difference between revisions

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[[Image:1nxd.png|left|200px|thumb|Crystal Structure of Concanavalin A, [[1nxd]]]]
<StructureSection load='1qdc' size='350' side='right' caption='Concanavalin A complex with trisacchride, Mn+2 (small purple), Cl- (large green) and Ca+2 (small green) ions (large purple) (PDB entry [[1qdc]])' scene='41/415806/Cv/1'>
{{STRUCTURE_1nxd|  PDB=1nxd  | SIZE=300| SCENE=Concanavalin_A/Concanavalin_a/1 |right|CAPTION=Concanavalin A, [[1nxd]] }}
__TOC__
== Function ==


'''Concanavalin A''' (ConA) is a carbohydrate-binding protein from jack-bean ( ''Canavalia ensiformis'').  It binds to certain sugars and to metal.  It is used to characterize glycoproteins on cell surfaces.
'''Concanavalin A''' (ConA) is a carbohydrate-binding protein from jack-bean (''Canavalia ensiformis'').  It binds to certain sugars and to metal.  It is used to characterize glycoproteins on cell surfaces.<ref>PMID:9546043</ref>. 
*'''Concanavalin B''' (ConB) is related to chitinase with 40% sequence identity.<ref>PMID:7490746</ref>. 
*'''Concanavalin BR''' (ConBR) is ConA from Brazilian jack bean.
*'''Concanavalin V''' (ConV) is a D-mannose/D-glucose-binding lectin.


{{TOC limit|limit=2}}
== Relevance ==


ConA has therapeutic effect on liver cancer.


== Structural highlights ==


ConA is the <scene name='41/415806/Cv/2'>homotetramer</scene> with D2 symmetry. ConA contains a <scene name='41/415806/Cv/7'>metal - Mn+2 and Ca+2 - binding site</scene> as well as a <scene name='41/415806/Cv/8'>sugar binding site</scene>.


== 3D Structures of Concanavalin A ==
== 3D Structures of Concanavalin ==
 
[[Concanavalin 3D structures]]
[[2uu8]], [[1nxd]], [[1gkb]], [[3enr]], [[1qny]], [[1vln]], [[1jbc]], [[1cnv]], [[2cna]], [[3cna]] – CeConA – ''Canavalia ensiformis''<br />
[[2yz4]], [[1xqn]], [[1c57]] – CeConA – neutron<br />
[[2ctv]] – CeConA – Laue<br />
[[1cn1]], [[1apn]], [[1dq0]], [[1dq2]] – CeConA demetallized<br />
[[2g4i]], [[2a7a]] – ConA – ''Canavalia virosa''<br />
[[1wuv]] – CgConA – ''Canavalia gladiata''<br />
[[3ju9]], [[1azd]] – ConBR – Brazilian jack-bean
 
===Concanavalin binary complex===
 
[[1dq1]], [[1dq5]], [[1dq6]], [[1qgl]], [[1nls]], [[1scr]], [[1scs]] – CeConA + ion<br />
[[1enq]], [[1enr]], [[1ens]], [[1con]], [[1dq4]], [[2enr]], [[1ces]] - CeConA demetallized + ion<br />
[[3d4k]] – CeConA + sugar analog<br />
[[1hqw]], [[1jyc]], [[1jyi]], [[1jui]], [[1joj]], [[1jw6]] – CeConA + polypeptide<br />
[[1jn2]] – CeConA + porphyrin derivative<br />
[[1cjp]], [[1ona]], [[1gic]], [[1val]], [[1vam]], [[5cna]] – CeConA + pyranoside derivative<br />
[[1i3h]], [[1qdc]], [[1qdo]], [[1bxh]], [[1tei]], [[1cvn]] – CeConA + glucoside<br />
[[2p37]] – ConA + glucoside – ''Canavalia maritima''<br />
[[2ef6]], [[2d7f]] - CgConA + glucoside
 
 


</StructureSection>


== References ==
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Latest revision as of 08:22, 6 February 2025

Concanavalin A complex with trisacchride, Mn+2 (small purple), Cl- (large green) and Ca+2 (small green) ions (large purple) (PDB entry 1qdc)

Drag the structure with the mouse to rotate

References

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Eran Hodis, Jaime Prilusky

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