Factor XIII: Difference between revisions
From Proteopedia
Jump to navigationJump to search
New page: left|200px|thumb|Crystal Structure of human Factor XIII, [[1ggt]] {{STRUCTURE_1ggt| PDB=1ggt | SIZE=300| SCENE= |right|CAPTION=Human Factor XIII, 1ggt }} [[Factor... |
Michal Harel (talk | contribs) No edit summary |
||
| (12 intermediate revisions by 2 users not shown) | |||
| Line 1: | Line 1: | ||
<StructureSection load='1ggt' size='350' side='right' caption='Human Factor XIII dimer (PDB entry [[1ggt]])' scene='Factor_XIII/Cv/1'> | |||
== Function == | |||
[[Factor XIII]] (FXIII) belongs to the blood coagulation system and crosslinks fibrin resulting in an insoluble clot. FXIII is activated by thrombin which cleaves it and releases an activation peptide. | [[Factor XIII]] (FXIII) belongs to the blood coagulation system and crosslinks fibrin resulting in an insoluble clot. FXIII is activated by thrombin which cleaves it and releases an activation peptide<ref>PMID:17842715</ref>. | ||
== Disease == | |||
FXIII deficiency causes internal bleeding. | |||
</StructureSection> | |||
== 3D Structures of Factor XIII == | == 3D Structures of Factor XIII == | ||
1ggt – hFXIII - human | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
1ex0 – hFXIII zymogen (mutant) | |||
1fie – hFXIII subunit A | [[1ggt]] – hFXIII - human <br /> | ||
1f13 - hFXIII zymogen subunit A | [[8cmt]], [[8cmu]] - hFXIII – Cryo EM<br /> | ||
1ggy, 1qrk, 1ggu, 1evu – hFXIII + ion | [[1ex0]] – hFXIII zymogen (mutant)<br /> | ||
1de7 – | [[1fie]] – hFXIII subunit A<br /> | ||
[[1f13]] - hFXIII zymogen subunit A dimer<br /> | |||
[[4kty]] - hFXIII subunit A + peptide-like ligand<br /> | |||
[[5mhl]], [[5mhm]], [[5mhn]], [[5mho]] - hFXIII subunit A (mutant) + peptide inhibitor<br /> | |||
[[1ggy]], [[1qrk]], [[1ggu]], [[1evu]] – hFXIII + ion<br /> | |||
[[1de7]] – hFXIII activation peptide + α-thrombin<br /> | |||
== References == | |||
<references/> | |||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Latest revision as of 08:48, 8 June 2025
| ||||||||||||
3D Structures of Factor XIII
Updated on 08-June-2025
1ggt – hFXIII - human
8cmt, 8cmu - hFXIII – Cryo EM
1ex0 – hFXIII zymogen (mutant)
1fie – hFXIII subunit A
1f13 - hFXIII zymogen subunit A dimer
4kty - hFXIII subunit A + peptide-like ligand
5mhl, 5mhm, 5mhn, 5mho - hFXIII subunit A (mutant) + peptide inhibitor
1ggy, 1qrk, 1ggu, 1evu – hFXIII + ion
1de7 – hFXIII activation peptide + α-thrombin
