3b0c: Difference between revisions
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New page: '''Unreleased structure''' The entry 3b0c is ON HOLD Authors: Nishino, T., Takeuchi, K., Gascoigne, K.E., Suzuki, A., Hori, T., Oyama, T., Morikawa, K., Cheeseman, I.M., Fukagawa, T. D... |
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The | ==Crystal structure of the chicken CENP-T histone fold/CENP-W complex, crystal form I== | ||
<StructureSection load='3b0c' size='340' side='right'caption='[[3b0c]], [[Resolution|resolution]] 2.20Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3b0c]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B0C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3B0C FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.201Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3b0c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b0c OCA], [https://pdbe.org/3b0c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3b0c RCSB], [https://www.ebi.ac.uk/pdbsum/3b0c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3b0c ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/CENPT_CHICK CENPT_CHICK] Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation (By similarity). The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres (By similarity). Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. CENPT has a fundamental role in kinetochore assembly and function. It is one of the inner kinetochore proteins, with most further proteins binding downstream. Required for normal chromosome organization and normal progress through mitosis.<ref>PMID:19070575</ref> <ref>PMID:22304917</ref> | |||
==See Also== | |||
*[[Centromere protein 3D structure|Centromere protein 3D structure]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Gallus gallus]] | |||
[[Category: Large Structures]] | |||
[[Category: Cheeseman IM]] | |||
[[Category: Fukagawa T]] | |||
[[Category: Gascoigne KE]] | |||
[[Category: Hori T]] | |||
[[Category: Morikawa K]] | |||
[[Category: Nishino T]] | |||
[[Category: Oyama T]] | |||
[[Category: Suzuki A]] | |||
[[Category: Takeuchi K]] | |||
Latest revision as of 14:03, 13 March 2024
Crystal structure of the chicken CENP-T histone fold/CENP-W complex, crystal form I
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