Beta-2 microglobulin: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
Michal Harel (talk | contribs)
32,838 edits
No edit summary
Michal Harel (talk | contribs)
32,838 edits
No edit summary
 
(55 intermediate revisions by 4 users not shown)
Line 1: Line 1:
{{STRUCTURE_3mrb|  PDB=3mrb  | SIZE=400| SCENE= |right|CAPTION=Human β-2 microglobulin (green) complex with MHC I (grey) and HCMV PP65 nonapeptide (cyan), [[3mrb]] }}
<StructureSection load='' size='350' side='right' scene='45/459284/Cv/1' caption='Human β-2 microglobulin (green) complex with MHC I (magenta) and HCMV PP65 nonapeptide (cyan), [[3mrb]]'>
[[Beta-2 microglobulin]] ('''B2M''') is a component of MHC class I system.  B2M associates with MHC class I α chain, CD1 and Qa.  Loss of B2M function causes iron excess. <ref>PMID:21131979</ref> For more details, see: [[Human beta two microglobulin]] and [[Molecular playground/beta 2 microglobulin]].
<br/>
[[Image:MHC Class 1.png|thumb|200px|left|Diagram of MHC I Complex]]
{{Clear}}
== Disease ==


'''Beta-2 microglobulin''' (B2M) is a component of MHC class I system.  B2M associates with MHC class I α chain, CD1 and Qa.  Loss of B2M function causes iron excess.  More details in [[Molecular playground/beta 2 microglobulin]].
Elevated B2M levels are found in patients of liver cirrhosis<ref>PMID:3884477</ref> and hepatitis<ref>PMID:29221492</ref>.  Dialysis-associated amyloidosis is a serious complication in chronic dialysis patients.  It is caused by B2M fibrils amyloid deposits<ref>PMID:10737162</ref>.


{{TOC limit|limit=2}}
== Relevance ==


== 3D Structures of β-2 microglobulin ==
B2M is used as a marker for certain types of blood cell cancer.  It can indicate the spread and severity of myeloma.


[[3na4]], [[3myz]], [[3ib4]], [[3ekc]], [[3dhj]], [[3dhm]], [[3ciq]], [[2z9t]], [[2d4d]], [[2f8o]], [[1py4]] - hβ-2-microglobulin (mutant) – human<BR />
== Structural Highlights ==
[[3qda]] - hβ-2-microglobulin residues 21-119 (mutant) <BR />
<scene name='45/459284/Cv/2'>Human β-2 microglobulin with MHC class I HLA-A2 and HCMV PP65 nonapeptide</scene> ([[3mrb]]).
[[2xks]], [[2xku]], [[1jnj]] - hβ-2-microglobulin – NMR<BR />
[[2vb5]] - hβ-2-microglobulin (mutant) – NMR<BR />
[[2e8d]] - hβ-2-microglobulin residues 40-61 - NMR<BR />
[[3low]], [[2yxf]], [[2d4f]], [[1lds]] - hβ-2-microglobulin<BR />
[[3gbl]] - β-2-microglobulin residues 1-97 - grass carp<BR />
[[1bmg]] - bβ-2-microglobulin - bovine


===B2M in binary complex with MHC===
== 3D Structures of β-2 microglobulin ==
 
[[Beta-2 microglobulin 3D structures]]
[[1zs8]] - mβ-2-microglobulin + mMHC  I – mouse<BR />
[[1r3h]] - mβ-2-microglobulin + mMHC II extracellular domain<BR />
[[2hla]], [[3hla]], [[1hla]] - hβ-2-microglobulin + hMHC  I<BR />
[[3p73]], [[3p77]] - cβ-2-microglobulin + cMHC  I – chicken
 
===B2M in binary complex with CD1===
 
[[3s6c]] - hβ-2-microglobulin/hCD1E<BR />
[[3ma7]], [[3ilp]], [[3ilq]], [[3g08]], [[3gml]], [[3gmm]], [[3gmn]], [[3gmo]], [[3gmp]], [[3gmq]], [[3gmr]], [[1zhn]] - mβ-2-microglobulin + CD1D1<BR />
[[2gaz]], [[2fik]] - mβ-2-microglobulin + CD1D1 extracellular domain<BR />
[[2akr]] - mβ-2-microglobulin residues 21-119+ CD1D1 extracellular domain<BR />
[[2h26]] - hβ-2-microglobulin + CD1B extracellular domain<BR />
[[3l9r]] - bβ-2-microglobulin + CD1B3<BR />
[[3jvg]] - cβ-2-microglobulin + CD1A1 ectodomain<BR />
 
===B2M in binary complex with other molecules===
 
[[1exu]] - hβ-2-microglobulin + Fc receptor<BR />
[[3fru]] - rβ-2-microglobulin + Fc receptor - rat<BR />
[[1c16]] - mβ-2-microglobulin + protein T22<BR />
[[1a6z]] - hβ-2-microglobulin + hemochromatosis protein<BR />
[[2x89]] - hβ-2-microglobulin + antibody<BR />
[[3mzt]] - hβ-2-microglobulin + thioflavin
 
===B2M in ternary complex with MHC===
 
[[2yf6]], [[3bew – cβ-2-microglobulin + cMHC I α + peptide<br />
[[2xfx]] - bβ-2-microglobulin + MHC I α + peptide<br />
[[3jts]], [[3jtt]], [[1zvs]] - β-2-microglobulin + MHC I α + peptide – Macaca mulatta<BR />
[[3kpn]], [[3kpo]] – hβ-2-microglobulin + hMHC I B + peptide<br />
[[3bev]], [[1kpr]], [[1k5n]], [[3nfn]], [[3mr9]], [[3mrb]], [[3mrc]], [[3mrd]], [[3mre]], [[3mrf]], [[3mrg]], [[3mrh]], [[3mri]], [[3mrj]], [[3mrk]], [[3mrl]], [[3mrm]], [[3mrn]], [[3mro]], [[3mrp]], [[3mrq]], [[3mrr]], [[3ox8]], [[3oxr]], [[3oxs]], [[2xpg]], [[3pwj]], [[3pwl]], [[3pwn]], [[3pwp]], [[2x70]], [[3o3a]], [[3o3b]], [[3o3d]], [[3o3e]], [[3lv3]], [[3ln4]], [[3ln5]], [[3myj]], [[3i6l]], [[3lkn]], [[3lko]], [[3lkp]], [[3lkq]], [[3lkr]], [[3lks]], [[3hpj]], [[3i6g]], [[3i6k]], [[3mgo]], [[3mgt]], [[3l3d]], [[3l3g]], [[3l3h]], [[3l3i]], [[3l3j]], [[3l3k]], [[2x4n]], [[2x4o]], [[2x4p]], [[2x4q]], [[2x4r]], [[2x4s]], [[2x4t]], [[2x4u]], [[3lka]], [[3h7b]], [[3kpl]], [[3kpm]], [[3kpn]], [[3kpo]], [[3kpp]], [[3kpq]], [[3kpr]], [[3kps]], [[3giv]], [[3hcv]], [[3d18]], [[3dtx]], [[3czf]], [[3fqn]], [[3fqr]], [[3fqt]], [[3fqu]], [[3fqw]], [[3fqx]], [[3d25]], [[3bvn]], [[3dx6]], [[3dx7]], [[3dx8]], [[3dxa]], [[3bo8]], [[3bp4]], [[3bp7]], [[3bgm]], [[3bh8]], [[3bh9]], [[3bhb]], [[3b3i]], [[3b6s]], [[2rfx]], [[3bze]], [[3bzf]], [[3bw9]], [[3bwa]], [[3c9n]], [[2v2w]], [[2v2x]], [[2gt9]], [[2gtw]], [[2gtz]], [[2guo]], [[2nw3]], [[2fyy]], [[2fz3]], [[2hn7]], [[2cik]], [[2git]], [[2hjk]], [[2hjl]], [[2h6p]], [[2d31]], [[2c7u]], [[2bck]], [[2a83]], [[2axf]], [[2axg]], [[2bvo]], [[2bvp]], [[2bvq]], [[1s8d]], [[1t1w]], [[1t1x]], [[1t1y]], [[1t1z]], [[1t20]], [[1t21]], [[1t22]], [[1s7q]], [[1zsd]], [[2bsr]], [[2bss]], [[2bst]], [[1zhk]], [[1zhl]], [[1tvb]], [[1tvh]], [[1xr8]], [[1xr9]], [[1w0v]], [[1w0w]], [[1xh3]], [[1uxs]], [[1uxw]], [[1s9w]], [[1s9x]], [[1s9y]], [[1q94]], [[1qvo]], [[1n2r]], [[1ogt]], [[1qew]], [[1jge]], [[1k5n]], [[1i7r]], [[1i7t]], [[1i7u]], [[1jf1]], [[1jht]], [[1i4f]], [[1e27]], [[1e28]], [[1i1y]], [[1i1f]], [[1qqd]], [[1mhe]], [[1b0g]], [[1a9b]], [[1a9e]], [[1a1m]], [[1a1n]], [[1a1o]], [[1tmc]], [[2clr]], [[1hhg]], [[1hhh]], [[1hhi]], [[1hhj]], [[1hhk]], [[1hsb]], [[1hsa]], [[3kla]], [[3giv]], [[3d18]], [[3bxn]], [[1x7q]], [[1ydp]], [[1sys]], [[1of2]], [[1jgd]], [[1eey]], [[1eez]], [[1duy]], [[1duz]], [[1agb]], [[1agc]], [[1agd]], [[1age]], [[1agf]] - hβ-2-microglobulin + hMHC I α + peptide<br />
[[1ktl]], [[3kww]], [[3h9h]], [[3ixa]], [[3gso]], [[3gsq]], [[3gsr]], [[3gsu]], [[3gsv]], [[3gsw]], [[3gsx]], [[3ft2]], [[3ft3]], [[3ft4]], [[2av1]], [[2av7]], [[1cg9]], [[1m05]], [[1m6o]], [[1kpr]], [[1ktl]], [[3kyn]], [[3kyo]], [[1qr1]] - β-2-microglobulin + hMHC I α (mutant) + peptide<br />
[[1syv]], [[1n2r]] - β-2-microglobulin + hMHC I + hMHC II peptide<br />
[[1kjv]], [[1kjm]], [[1ed3]] – rβ-2-microglobulin + MHC I α + peptide<br />
[[3bev]], [[3bew]], [[2yf6]] - cβ-2-microglobulin + cMHC I α + peptide<br />
[[1kbg]], [[3l3h]], [[3ftg]], [[3e6f]], [[3ecb]], [[3ch1]], [[3cch]], [[3cc5]], [[3cpl]], [[2zsv]], [[2zsw]], [[2zok]], [[2zol]], [[3buy]], [[2ve6]], [[2e7l]], [[2fo4]], [[2cii]], [[2fwo]], [[2f74]], [[1zt1]], [[1zt7]], [[1vgk]], [[1yn6]], [[1yn7]], [[1zhb]], [[1wbx]], [[1wby]], [[1wbz]], [[1rjy]], [[1rjz]], [[1rk0]], [[1rk1]], [[1t0m]], [[1t0n]], [[1s7q]], [[1s7r]], [[1s7s]], [[1s7t]], [[1s7u]], [[1s7v]], [[1s7w]], [[1s7x]], [[1lk2]], [[1kpu]], [[1kpv]], [[1n3n]], [[1nan]], [[1n59]], [[1n5a]], [[1ffn]], [[1ffo]], [[1ffp]], [[1g7p]], [[1g7q]], [[1lek]], [[1leg]], [[1inq]], [[1juf]], [[1k8d]], [[1jpf]], [[1jpg]], [[1fg2]], [[1qlf]], [[1bz9]], [[1kbg]], [[1hoc]], [[2mha]], [[1vad]], [[1vac]], [[3fol]], [[3fom]], [[3fon]], [[1ce6]], [[1osz]], [[1bii]], [[1ld9]], [[2vaa]], [[2vab]] - mβ-2-microglobulin + mMHC I + peptide<br />
[[2qri]], [[3nwm]] - mβ-2-microglobulin/mMHC  I/peptide<br />
[[2qrs]], [[2qrt]] - mβ-2-microglobulin/mMHC  I (mutant )/peptide<br />
[[1mhc]], [[2clv]], [[2clz]], [[1fzj]], [[1fzk]], [[1fzm]], [[1fzo]], [[1ddh]] – mβ-2-microglobulin + mMHC  I (mutant)  + peptide<br />
[[1ypz]] - mβ-2-microglobulin + mMHC  II + T cell receptor
 
===B2M in ternary complex with CD1===
 
[[3qux]], [[3quy]], [[3quz]], [[3o8x]], [[3o9w]] - mβ-2-microglobulin + T cell receptor + CD1D1<BR />
[[2po6]] - hβ-2-microglobulin + T cell receptor NKT15 + CD1D<BR />
[[3dbx]] - cβ-2-microglobulin + CD1-2 + fatty acid<BR />
[[1zhn]] - mβ-2-microglobulin + CD1D1 + phosphatidylcholine<BR />
[[1zt4]] - mβ-2-microglobulin + CD1D1 + ceramide derivative<br />
[[1xz0]] - hβ-2-microglobulin + CD1A + lipopeptide<br />
[[1onq]] - hβ-2-microglobulin + CD1A + sulfatide<br />
[[1uqs]] - hβ-2-microglobulin + CD1B + glycolipid<BR />
[[1gzp]], [[1gzq]] - hβ-2-microglobulin + CD1B + ceramide derivative<br />
[[1nez]] - mβ-2-microglobulin + mMHC  I + CD8 α chain
 
===B2M in ternary complex with other molecules===
 
[[1i1a]], [[1frt]] - rβ-2-microglobulin + Fc receptor + Fc fragment<BR />
[[1de4]] - hβ-2-microglobulin + hemochromatosis protein + transferring receptor<BR />
[[3m17]], [[3m1b]] - hβ-2-microglobulin + FcRn+ peptide<br />
 
===B2M in quaternary complex with MHC===
 
[[3qdg]], [[3qdj]], [[3qdm]], [[3qeq]], [[3mv7]], [[3mv8]], [[3mv9]], [[3h9s]], [[3gsn]], [[3d39]], [[3d3v]], [[3ffc]], [[2vlj]], [[2vlk]], [[2vll]], [[2vlr]], [[2j8u]], [[2p5e]], [[2p5w]], [[2pye]], [[2gj6]], [[2f54]], [[2esv]], [[2bnq]], [[2bnr]], [[1lp9]], [[1oga]], [[1mi5]], [[1qrn]], [[2nx5]], [[2ak4]], [[1qse]], [[1qsf]], [[1bd2]], [[1ao7]] - hβ-2-microglobulin + hMHC  I α + T cell receptor + peptide<br />
[[3kxf]], [[3mv8]], [[2jcc]], [[2uwe]] - β-2-microglobulin + hMHC  I α (mutant) + T cell receptor + peptide<br />
[[2f53]] - β-2-microglobulin (mutant) +  hMHC  I α + T cell receptor + peptide<br />
[[1p7q]], [[1im9]] - β-2-microglobulin + hMHC  I α + leukocyte immunoglobulin-like receptor + peptide<br />
[[2dyp]] - β-2-microglobulin + hMHC  I α (mutant) + leukocyte immunoglobulin-like receptor + peptide<br />
[[3qzw]], [[3dmm]], [[1bqh]], [[1akj]] - hβ-2-microglobulin + hMHC I α + CD8 α + peptide<br />
[[1im3]] - hβ-2-microglobulin + hMHC I α + cytomegalovirus protein US2 + peptide<br />
[[3cii]], [[3cdg]] - hβ-2-microglobulin + hMHC I α + CD94 ectodomain + NKG2A/NKG2B integral membrane protein + peptide<br />
[[3hae]], [[3gjf]], [[3cvh]], [[1w72]] - hβ-2-microglobulin + hMHC I α + antibody + peptide<br />
[[1g6r]], [[2ckb]], [[3pqy]], [[2z31]], [[1nam]], [[1mwa]], [[1g6r]], [[2ckb]], [[2ol3]], [[1kj2]], [[1kj3]], [[1fo0]] - mβ-2-microglobulin + mMHC  I + T cell receptor  + peptide<br />
[[2oi9]], [[3rgv]] - mβ-2-microglobulin + mMHC  I (mutant) + T cell receptor + peptide<br />
[[1p1z]], [[1p4l]], [[1qo3]], [[1efx]] - β-2-microglobulin + mMHC  I  + natural killer cell receptor + peptide<br />
[[3c8k]] - β-2-microglobulin + mMHC  I (mutant) + natural killer cell receptor LY49C + peptide<br />
[[3o4l]] - hβ-2-microglobulin +MHC I + BSLF2/BMLF1 + T cell receptor<BR />
[[3hg1]] - hβ-2-microglobulin +MHC I + cancer/MART-1+ T cell receptor<BR />
[[3gjf]] - hβ-2-microglobulin + hMHC  I + antibody + peptide<br />
 
===B2M in quaternary complex with CD1===
 
[[2q7y]] - mβ-2-microglobulin + CD1D1 + ceramide derivative + fatty acid<BR />
[[3arb]], [[3ard]], [[3are]], [[3arf]], [[3arg]], [[3he6]], [[3he7]], [[3huj]] - mβ-2-microglobulin + T cell receptor NKT + CD1D1 + ceramide derivative<br />
 
===B2M in quaternary complex with other molecules===
 
[[3d2u]] - hβ-2-microglobulin + UL18 + leukocyte immunoglobulin-like receptor + peptide<br />


</StructureSection>


== References ==
<references/>




Latest revision as of 08:10, 26 February 2020

Humanβ-2 microglobulin (green) complex with MHC I (magenta) and HCMV PP65 nonapeptide (cyan), 3mrb

Drag the structure with the mouse to rotate

References

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, David Canner, Joel L. Sussman

Retrieved from "https://proteopedia.org/index.php?title=Beta-2_microglobulin&oldid=3160461"