2y3y: Difference between revisions

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[[Image:2y3y.jpg|left|200px]]


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==Holo-Ni(II) HpNikR is a symmetric tetramer containing four canonic square-planar Ni(II) ions at physiological pH==
The line below this paragraph, containing "STRUCTURE_2y3y", creates the "Structure Box" on the page.
<StructureSection load='2y3y' size='340' side='right'caption='[[2y3y]], [[Resolution|resolution]] 2.39&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2y3y]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Helicobacter_pylori_G27 Helicobacter pylori G27] and [https://en.wikipedia.org/wiki/Unidentified Unidentified]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y3Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Y3Y FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.39&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
{{STRUCTURE_2y3y|  PDB=2y3y  |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2y3y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y3y OCA], [https://pdbe.org/2y3y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2y3y RCSB], [https://www.ebi.ac.uk/pdbsum/2y3y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2y3y ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NIKR_HELPG NIKR_HELPG] Transcriptional regulator.[HAMAP-Rule:MF_00476]
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The crystal structure of Helicobacter pylori holo-NikR, a Ni(2+)-dependent transcription factor, determined at pH 7.3, shows four square-planar nickel-binding sites, involving one cysteinate and three histidine ligands. This observation reconciles previous inconsistencies among calorimetric data, structural information at non-physiological pH, and computational studies.


===HOLO-NI(II) HPNIKR IS A SYMMETRIC TETRAMER CONTAINING FOUR CANONIC SQUARE-PLANAR NI(II) IONS AT PHYSIOLOGICAL PH===
Holo-Ni(2+)Helicobacter pylori NikR contains four square-planar nickel-binding sites at physiological pH.,Benini S, Cianci M, Ciurli S Dalton Trans. 2011 Aug 21;40(31):7831-3. Epub 2011 Jul 4. PMID:21725560<ref>PMID:21725560</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
The line below this paragraph, {{ABSTRACT_PUBMED_21725560}}, adds the Publication Abstract to the page
<div class="pdbe-citations 2y3y" style="background-color:#fffaf0;"></div>
(as it appears on PubMed at http://www.pubmed.gov), where 21725560 is the PubMed ID number.
== References ==
-->
<references/>
{{ABSTRACT_PUBMED_21725560}}
__TOC__
 
</StructureSection>
==About this Structure==
[[Category: Helicobacter pylori G27]]
[[2y3y]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori_g27 Helicobacter pylori g27] and [http://en.wikipedia.org/wiki/Unidentified Unidentified]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y3Y OCA].
[[Category: Large Structures]]
 
==Reference==
<ref group="xtra">PMID:021725560</ref><references group="xtra"/>
[[Category: Helicobacter pylori g27]]
[[Category: Unidentified]]
[[Category: Unidentified]]
[[Category: Benini, S.]]
[[Category: Benini S]]
[[Category: Cianci, M.]]
[[Category: Cianci M]]
[[Category: Ciurli, S.]]
[[Category: Ciurli S]]
[[Category: Metal binding]]
[[Category: Transcription]]

Latest revision as of 08:08, 23 August 2023

Holo-Ni(II) HpNikR is a symmetric tetramer containing four canonic square-planar Ni(II) ions at physiological pH

2y3y, resolution 2.39Å

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