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| {{STRUCTURE_1zg1| PDB=1zg1 | SIZE=400| SCENE= |right|CAPTION=Se-Met ''E. coli'' response regulator NarL complex with DNA and sulfate, [[1zg1]] }}
| | <StructureSection load='1kgs' size='350' side='right' scene='' caption='Se-Met DNA-binding response regulator D complex with thiocyanate, [[1kgs]]'> |
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| '''Response regulators''' (RR) are part of the two-component signal transduction systems which enable bacteria to sense and respond to a wide range of environments. | | '''Response regulators''' (RR) are part of the two-component signal transduction systems which enable bacteria to sense and respond to a wide range of environments. |
| Two-component RR is a complex of histidine kinase (sensor protein SP) and RR. The RR act as phosphorylation-activated switches. Most RR consist of N terminal shich is the signal receiving domain and C terminal which is the DNA-binding domain. For details on response regulator PleD see [[PleD activation]], [[PleD allosteric product inhibition]], [[PleD catalysis]]. | | Two-component RR is a complex of histidine kinase (sensor protein SP) and RR. The RR act as phosphorylation-activated switches. Most RR consist of N terminal which is the signal receiving domain and C terminal which is the DNA-binding domain (DBD). |
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| | *'''RR CheY''' is a chemotaxis response regulator in bacteria see [[Chemotaxis protein]].<ref>PMID:14563873</ref>. <br /> |
| | *'''RR Spo0''' is the sporulation response regulator<ref>PMID:12829280</ref>. <br /> |
| | *'''RR PleD''' is required in loss of motility<ref>PMID:7592388</ref>. For details see [[PleD activation]], [[PleD allosteric product inhibition]], [[PleD catalysis]] and [[Response regulator PLED in complex with C-di-GMP]]<br /> |
| | *'''RR PhoP''' is important for survival under conditions of macrophage-induced stress<ref>PMID:21634789</ref>. For details see [[PhoP Regulatory Domain]] and [[PhoP-PhoQ]]<br /> |
| | *'''Photosynthetic apparatus RR''' in ''Rhodobacter sphaeroides'' is involved in the transduction of signals which monitor oxygen levels. <ref>PMID:8955382</ref>. For details see [[PrrA in Rhodobacter sphaeroides]] <br /> |
| | *'''RR WspR''' couples the chemosensory Wsp pathway to the overproduction of acetylated cellulase <ref>PMID:17379708</ref>. For details see [[WspR]].<br /> |
| | *'''Redox RR''' is DNA-sequence specific. It controls transcription as a result of its phosphorylation by a redox sensor<ref>PMID:8405457</ref>. <br /> |
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| {{TOC limit|limit=2}}
| | For '''iron response regulator Irr''' see [[Irr]]. |
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| == 3D Structures of response regulator == | | == 3D Structures of response regulator == |
| | [[Response regulator 3D structure]] |
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| [[3sft]] – TmCheB methyltransferase catalytic domain – ''Thermotoga maritima''<br />
| | </StructureSection> |
| [[1p2f]] – TmDrrB<br />
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| [[3gl9]], [[3dgf]] – TmRR<br />
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| [[3snk]] – CheY-like – ''Mesorhizobium loti''<br />
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| [[3crn]], [[3cg4]] - CheY-like – ''Methanospirillum hungatei''<br />
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| [[1ixm]] – BsSpo0B<br />
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| [[1nat]] – BsSPo0F<br />
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| [[1srr]] - BsSPo0F (mutant) <br />
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| [[3p3q]] – McMmoQ (mutant) – ''Methylococcus capsulatus''<br />
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| [[3ljx]] – McMmoQ residues 20-298<br />
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| [[3n0r]] – CvPhyR – ''Caulobacter vibrioides''<br />
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| [[1m5t]], [[1m5u]] - CvDivK<br />
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| [[3n53]] – RR – ''Pelobacter carbinolicus''<br />
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| [[3nhm]] – MxRR – ''Myxococcus xanthus''<br />
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| [[3kto]] - RR – ''Pseudoalteromonas atlantica''<br />
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| [[3f7a]], [[3eq2]] – PaRssB – ''Pseudomonas aeruginosa''<br />
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| [[3es2]] – PaRssB phosphatase domain<br />
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| [[3i5b]] – PaWpsR GGDEF domain<br />
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| [[3i5c]] - PaWpsR GGDEF domain/GCN4 leucine zipper<br />
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| [[1yio]], [[1zn2]] – PfStyR – ''Pseudomonas fluorescens''<br />
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| [[3hdv]] – RR – ''Pseudomonas putida''<br />
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| [[3i5a]] – WpsR – ''Pseudomonas syringae''<br />
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| [[3heb]] – CheY – ''Rhodospirillum rubrum''<br />
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| [[3eqz]] – CpRR – ''Colwellia psychrerythraea''<br />
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| [[2zay]] – RR residues 150-285 – ''Desulfuromonas acetoxidans''<br />
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| [[2rdm]] – RR (mutant) – ''Sinorhizobium medicae''<br />
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| [[1xhe]] – EcArcA (mutant) - ''Escherichia coli''<br />
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| [[1jbe]] - EcCheY<br />
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| [[1nxo]], [[1nxp]], [[1nxs]], [[1nxt]], [[1nxv]], [[1nxw]], [[1nxx]] – SpRR MICA receiver domain<br />
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| [[2gwr]] – MtMtrA - ''Mycobacterium tuberculosis''<br />
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| [[1ys6]] – MtPrrA<br />
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| [[1k66]] – ToRcpB – ''Tolypothrix''<br />
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| [[1k68]] – ToRcpA<br />
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| [[3p01]] – RR residues 134-315 – ''Nostoc''<br />
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| [[3ilh]] – RR – ''Cytophaga hutchinsonii''<br />
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| [[3c3w]] – MtDosR <br />
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| [[2qvg]] – RR – ''Legionella pneumophila''<br />
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| [[2qr3]] – RR – ''Bacterioides fragilis''<br />
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| ===Response regulator signal receiving domain===
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| [[2qxy]] – TmRR <br />
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| [[3i42]] - CheY-like – ''Methylobacillus flagellatus''<br />
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| [[2zwm]]– BsYycF <br />
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| [[1mvo]] - BsPhoP <br />
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| [[3gkg]], [[2i6f]] – MxFrzS <br />
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| [[2nt3]], [[2nt4]] - MxFrzS (mutant) <br />
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| [[3lte]] – RR – ''Bermanella marisrubri''<br />
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| [[3hv2]] – PfRR <br />
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| [[3kht]] – RR – ''Hahella chejuensis''<br />
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| [[3jte]] – CtRR - ''Clostridium thermocellum''<br />
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| [[3cnb]] – CpRR <br />
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| [[3c3m]] – RR – ''Methanoculleus marisnigri''<br />
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| [[2qsj]] – LuxR – ''Silicibacter pomeroyi''<br />
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| [[2pln]] – RR – ''Helicobacter pylori''<br />
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| [[2jb9]], [[2jba]] – EcPhoB (mutant) <br />
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| [[3lua]] – CtRR<br />
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| [[3lsg]] – YesN – ''Fusobacterium nucleatum''<br />
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| [[3cz5]] – LuxR – ''Aurantimonas''<br />
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| [[2qzj]] – RR – ''Clostridium difficile''<br />
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| [[1a04]], [[1rnl]] – EcNarL
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| ===Response regulator DNA-binding domain===
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| [[2zxj]] - SaYycF - ''Staphylococcus aureus''<br />
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| [[2rnj]] - SaVraR - NMR<BR />
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| [[2hwv]] – VicR – ''Enterococcus faecalis''<br />
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| [[1umq]] – PrrA – ''Rhodobacter sphaeroides'' – NMR<BR />
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| [[3c57]] – MtDosR <br />
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| [[2pmu]] – MtPhoP
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| ===Response regulator complex===
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| [[3nnn]] – TmDrrD signal receiving domain + BeF3<br />
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| [[3nns]] – TmDrrB signal receiving domain + BeF3<br />
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| [[3a0u]] - TmTrrA + Mg + BeF3<br />
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| [[3a10]] - TmTrrA (mutant) + Mg + BeF3<br />
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| [[3rqi]] – RR + phosphorylated aspartic acid + citrate + Ca – ''Burkholderia pseudomallei''<br />
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| [[3q15]] – BsRapH + sporulation initiation phosphotransferase – ''Bacillus subtilis''<br />
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| [[3m6m]] – RpfF residues 400-541 + RpfF protein REC domain – ''Xanthomonas campestris''<br />
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| [[1mav]], [[1mb0]], [[1mb3]] – CvDivK + metal ion<br />
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| [[2wb4]] – PleD + cyclic diguanosine monophosphate + BeF3 – ''Caulobacter crescentus''<br />
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| [[2v0n]] – CvPleD residues 2-454 + cyclic diguanosine monophosphate + GTP + BeF3<br />
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| [[3hzh]] – CheX + CheY + Mg + BeF3 – ''Borrelia burgdorferi''<br />
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| [[1xhf]] - EcArcA (mutant) + BeF3<br />
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| [[2a9o]], [[2a9p]], [[2a9q]], [[2a9r]] – SpYycF + BeF3 – ''Streptococcus pneumoniae''<br />
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| [[1ys7]] – MtPrrA + Mg<br />
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| [[1jlk]], [[1i3c]] – Rcp1 + Mn]] - ''Synechocystis''<br />
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| [[3dge]] – TmRR + SP cytoplasmic domain<br />
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| [[3a0r]] – TmTrrA + histidine kinase ThkA<br />
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| [[1zg1]], [[1zg5]], [[1je8]] – EcNarL DNA-binding domain + DNA
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| | == References == |
| | <references/> |
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| [[Category:Topic Page]] | | [[Category:Topic Page]] |
