Cytolysin: Difference between revisions
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<StructureSection load='4owk' size='450' side='right' caption='Cytolysin complex with N-acetyl-D-galactosamine and glycerol (PDB code [[4owk]]).' scene='46/462210/Cv/1' pspeed='8'> | |||
== Function == | |||
'''Cytolysins''' are <scene name='46/462210/Cv/4'>β-barrel</scene> ({{Template:ColorKey_Helix}},{{Template:ColorKey_Strand}},{{Template:ColorKey_Loop}}, {{Template:ColorKey_Turn}}) [[Pore-forming toxins|pore-forming toxins]] secreted by a variety of organisms and causing cell lysis. | |||
*'''Anthrolysin O''' is a pore-forming, cholesterol-dependent cytolysin secreted by ''Bacillus anthracis''<ref>PMID:24862282</ref>.<br /> | |||
*'''Equinatoxin''' is an α-helical pore-forming toxin that pirate cellular membranes by the use of α-helices <ref>PMID:23803608</ref>.<br /> | |||
*'''Fragaceaatoxin''' is a sea anemone toxin <ref>PMID:19563820</ref>.<br /> | |||
*'''Intermedilysin''' is human-specific toxin found in liver abscesses <ref>PMID:8757839</ref>.<br /> | |||
*'''Listerolysin O''' is a pore-forming, cholesterol-dependent cytolysis secreted by ''Listeria monocytogenes''<ref>PMID:17720603</ref>.<br /> | |||
*'''Lysenin''' is small β-pore-forming toxin secreted by an earthworm<ref>PMID:27048994</ref>.<br /> | |||
*'''[[Perforin]]''' is produced by killer lymphocytes and released by cytoplasmic granules<ref>PMID:7734048</ref>.<br /> | |||
*'''Perfringolysin O''' is a pore-forming, cholesterol-dependent cytolysin secreted by ''Clostridium perfringens''<ref>PMID:16701509</ref>.<br /> | |||
*'''Pneumolysin''' is a virulence factor which augments intrapulmonary growth and dissemination during the early infection ''Streptococcus pneumonia''<ref>PMID:9452123</ref>.<br /> | |||
*'''Sticholysin''' is a pore-forming toxin secreted by sea anemone<ref>PMID:19268489</ref>.<br /> | |||
*'''Stonustoxin''' is a lethal factor secreted by stonefish<ref>PMID:9271089</ref>.<br /> | |||
*'''Streptolysin O''' is a thin-activated membrane-damaging protein which is produced by β-hemolytic group A streptococci<ref>PMID:3880730</ref>.<br /> | |||
See also [[Molecular Playground/ClyA|Cytolysin A]] and [[Hemolysin]]. | |||
== Relevance == | |||
Steptolysin O has the potential to establish a new class of suicide gene therapeutic reagents<ref>PMID:16818521</ref> as well as reversibly permeabilize adherent and non-adherent cells allowing the delivery of molecules with up to 100 kDa mass to the cytosol<ref>PMID:11248053</ref>. | |||
== Structural highlights == | |||
<scene name='46/462210/Cv/3'>Cytolysin β-trefoil lectin binds a disaccharide</scene><ref>PMID:24862282</ref>. | |||
==3D structures of Cytolysin== | |||
[[Cytolysin 3D structures]] | |||
</StructureSection> | |||
== References == | |||
<references/> | |||
[[Category:Topic Page]] | |||
