3u15: Difference between revisions
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New page: '''Unreleased structure''' The entry 3u15 is ON HOLD Authors: Lukacs, C.M., Janson, C.A., Graves, B.J. Description: Structure of hDMX with Dimer Inducing Indolyl Hydantoin RO-2443 |
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==Structure of hDMX with Dimer Inducing Indolyl Hydantoin RO-2443== | |||
<StructureSection load='3u15' size='340' side='right'caption='[[3u15]], [[Resolution|resolution]] 1.80Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3u15]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U15 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3U15 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=03M:(5Z)-5-[(6-CHLORO-7-METHYL-1H-INDOL-3-YL)METHYLIDENE]-3-(3,4-DIFLUOROBENZYL)IMIDAZOLIDINE-2,4-DIONE'>03M</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3u15 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u15 OCA], [https://pdbe.org/3u15 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3u15 RCSB], [https://www.ebi.ac.uk/pdbsum/3u15 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3u15 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/MDM4_HUMAN MDM4_HUMAN] Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions.<ref>PMID:16163388</ref> <ref>PMID:16511572</ref> | |||
==See Also== | |||
*[[MDM4|MDM4]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Graves BJ]] | |||
[[Category: Janson CA]] | |||
[[Category: Lukacs CM]] | |||
Latest revision as of 13:45, 14 March 2024
Structure of hDMX with Dimer Inducing Indolyl Hydantoin RO-2443
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