3u49: Difference between revisions
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==Crystal structure of YwfH, NADPH dependent reductase involved in Bacilysin biosynthesis== | |||
<StructureSection load='3u49' size='340' side='right'caption='[[3u49]], [[Resolution|resolution]] 1.75Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3u49]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U49 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3U49 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3u49 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u49 OCA], [https://pdbe.org/3u49 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3u49 RCSB], [https://www.ebi.ac.uk/pdbsum/3u49 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3u49 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/BACG_BACSU BACG_BACSU] Along with the bacABCDEF operon, BacG is involved in the biosynthesis of the nonribosomally synthesized dipeptide antibiotic bacilysin, composed of L-alanine and L-anticapsin. Bacilysin is an irreversible inactivator of the glutaminase domain of glucosamine synthetase (PubMed:20052993). BacG catalyzes the stereoselective reduction of exocyclic-delta(3),delta(5)-dihydro-hydroxyphenylpyruvate (ex-H2HPP), adding a pro-S hydride equivalent to C4 position to yield tetrahydro-hydroxyphenylpyruvate (H4HPP) (PubMed:22765234, PubMed:23519407). Although the 3Z,7R-ex-H2HPP isomer is kinetically disfavored by BacB and produced in a smaller quantity than 3E,7R-ex-H2HPP, it is the preferred substrate for the conjugate reduction reaction of BacG (PubMed:22765234, PubMed:23519407).<ref>PMID:20052993</ref> <ref>PMID:22765234</ref> <ref>PMID:23519407</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Bacillus subtilis]] | |||
[[Category: Large Structures]] | |||
[[Category: Gopal B]] | |||
[[Category: Rajavel M]] | |||
Latest revision as of 08:38, 20 March 2024
Crystal structure of YwfH, NADPH dependent reductase involved in Bacilysin biosynthesis
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